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Maternal antibodies induced by a live attenuated vaccine protect neonatal mice from cytomegalovirus
Human cytomegalovirus (HCMV) frequently causes congenital infections, resulting in birth defects and developmental disorders. A vaccine is needed,...
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The attenuated live vaccine strain W2512 provides protection against novel variant infectious bursal disease virus
Infectious bursal disease virus (IBDV) causes an acute and highly contagious infectious disease characterized by severe immunosuppression, causing...
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An effective live-attenuated Zika vaccine candidate with a modified 5′ untranslated region
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has caused devastating congenital Zika syndrome (CZS), including microcephaly, congenital...
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Expression of the SARS-CoV-2 receptor-binding domain by live attenuated influenza vaccine virus as a strategy for designing a bivalent vaccine against COVID-19 and influenza
Influenza and SARS-CoV-2 are two major respiratory pathogens that cocirculate in humans and cause serious illness with the potential to exacerbate...
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A single-dose of intranasal vaccination with a live-attenuated SARS-CoV-2 vaccine candidate promotes protective mucosal and systemic immunity
An attenuated SARS-CoV-2 virus with modified viral transcriptional regulatory sequences and deletion of open-reading frames 3, 6, 7 and 8 (∆3678) was...
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Mucosal bivalent live attenuated vaccine protects against human metapneumovirus and respiratory syncytial virus in mice
Live-Attenuated Vaccines (LAVs) stimulate robust mucosal and cellular responses and have the potential to protect against Respiratory Syncytial Virus...
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Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells
Glioblastoma multiforme (GBM) is the most common malignant primary brain cancer affecting the adult population. Median overall survival for GBM...
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Development of an attenuated vaccine against Koi Herpesvirus Disease (KHVD) suitable for oral administration and immersion
Since the end of the1990ies, Cyprinid herpesvirus 3 (also known as koi herpesvirus, KHV) has caused mass mortality events of koi and common carp all...
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Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 global pandemic. SARS-CoV-2 is an enveloped RNA...
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Vacuum Foam Drying Method Improved the Thermal Stability and Long-Term Shelf Life of a Live Attenuated Newcastle Disease Virus Vaccine
Vaccines used for managing Newcastle disease virus (NDV) rely heavily on cold chain, and this results in major constraints in their successful...
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Production performance and economic analysis of broiler chickens after vaccination with a live attenuated vaccine against avian coccidiosis
The objective of this study was to evaluate the effectiveness of live attenuated commercial vaccine LIVACOX® T against avian coccidiosis upon...
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Live attenuated pertussis vaccine for prevention and treatment of allergic airway inflammation in mice
Live attenuated vaccines often have beneficial non-specific effects, protecting against heterologous infectious and non-infectious diseases. We have...
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Prophylactic Hepatitis E Vaccine
The hepatitis E has been increasingly recognized as an underestimated global disease burden in recent years. Subpopulations with more serious...
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Multiple Immune Defects in Two Patients with Novel DOCK2 Mutations Result in Recurrent Multiple Infection Including Live Attenuated Virus Vaccine
The dedicator of cytokinesis 2(DOCK2) protein, an atypical guanine nucleotide exchange factor (GEFs), is a member of the DOCKA protein subfamily....
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Long-term protective immunity to goatpox in goats after a single immunization with a live attenuated goatpox vaccine
In this study, the duration of immunity following a single-dose vaccination using an attenuated live goatpox vaccine (GTPV/Uttarkashi/1978 strain)...
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Recent progress on gene-deleted live-attenuated African swine fever virus vaccines
African Swine Fever (ASF) is a highly lethal viral disease in swine, with mortality rates approaching 100%. The disease has spread to many...
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Vaccine Development for Human Leishmaniasis
The development of vaccines for human leishmaniasis is one of the most important approaches for effectively controlling and/or eradicating the...
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The potential of swine pseudorabies virus attenuated vaccine for oncolytic therapy against malignant tumors
BackgroundOncolytic viruses are now well recognized as potential immunotherapeutic agents against cancer. However, the first FDA-approved oncolytic...
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Vaccine Development Against Melioidosis
Melioidosis in an infectious disease of humans and animals caused by the bacterium Burkholderia pseudomallei. Melioidosis is often considered a...
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Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals
Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA, adenoviral vector and inactivated...
