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Gluten Ataxia
Gluten ataxia (GA) is defined as sporadic ataxia with positive serological markers for gluten sensitivity and in the absence of an alternative... -
Friedreich Ataxia
Friedreich ataxia (FA) is an autosomal recessive cerebellar ataxia. The disorder manifests progressively, with the first symptoms typically starting... -
Ataxia Telangiectasia
Ataxia Telangiectasia (A-T) is a rare autosomal recessive disorder associated with early onset cerebellar neurodegeneration, respiratory disease,... -
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Single-Session Cerebellar Transcranial Direct Current Stimulation Improves Postural Stability and Reduces Ataxia Symptoms in Spinocerebellar Ataxia
Spinocerebellar ataxia (SCA) results in balance and coordination impairment, and current treatments have limited efficacy. Recent evidence suggests...
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Metabolic Treatments of Cerebellar Ataxia
Metabolic causes of cerebellar ataxia encompass all categories of inherited metabolic diseases, i.e., accumulation and deficiency of small or complex... -
Clinical Rating Scales for Ataxia
Clinical rating scales for ataxia yield a semi-quantitative measure of disease severity. Rating is based on standardized scoring, usually applied on... -
Rehabilitation in Cerebellar Ataxia
The cerebellum is a unique structure that is densely connected to both motor and nonmotor regions of the brain and plays a critical role in... -
Physical Therapy in Cerebellar Ataxia
Given the essential role of the cerebellum in coordinating and refining motor behavior, people with cerebellar disease exhibit significant disability... -
Overview of Ataxia in Childhood
In children, a wide number of hereditary or acquired diseases may cause ataxia. The prevalence varies significantly in causes between pediatric and... -
Ataxia in Multiple Sclerosis
It is well known that the cerebellum is commonly affected in patients with multiple sclerosis (MS), thus making everyday life activities such as... -
Using Smartphone Sensors for Ataxia Trials: Consensus Guidance by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers
Smartphone sensors are used increasingly in the assessment of ataxias. To date, there is no specific consensus guidance regarding a priority set of...
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Ataxia Scales for the Clinical Evaluation
The International Cooperative Ataxia Rating Scale (ICARS), the Friedreich Ataxia Rating Scale (FARS), the Scale for the Assessment and Rating of... -
Quantitative Speech Assessment in Ataxia—Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Markers
Dysarthria is a common and debilitating symptom of many neurodegenerative diseases, including those resulting in ataxia. Changes to speech lead to...
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Primary Autoimmune Cerebellar Ataxia (PACA)
Immune-mediated ataxias are likely to account for a large number of progressive ataxias. Advances in the field of immune-mediated ataxias meant that... -
Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers
With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly...
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Ion Channel Genes and Ataxia
In this review we will discuss ataxic disorders attributed to mutations in ion channel genes. Such disorders seem to preferentially effect cerebellar... -
Quantitative Oculomotor Assessment in Hereditary Ataxia: Systematic Review and Consensus by the Ataxia Global Initiative Working Group on Digital-motor Biomarkers
Oculomotor deficits are common in hereditary ataxia, but disproportionally neglected in clinical ataxia scales and as outcome measures for...
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Psychometric Validation of the Modified Functional Scale for the Assessment and Rating of Ataxia (f-SARA) in Patients With Spinocerebellar Ataxia
This study aimed to generate evidence to support psychometric validity of the modified functional Scale for the Assessment and Rating of Ataxia...
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Content Validity of the Modified Functional Scale for the Assessment and Rating of Ataxia (f-SARA) Instrument in Spinocerebellar Ataxia
The functional Scale for the Assessment and Rating of Ataxia (f-SARA) assesses Gait, Stance, Sitting, and Speech. It was developed as a potentially...