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Introduction to Pulmonary Diseases and OMICS Approaches
Incidence of diseases affecting the respiratory tract and lungs have increased in the past few decades. Exposure to harmful environmental triggers,...
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The Role of Biologics in the Treatment of Chronic Rhinosinusitis
The last decade has seen significant developments in the field of biologics for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP)....
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Asthma
Cutting edge omics approaches have led to phenoty** and sub-phenoty** of asthma based on underlying molecular endotypes. T2-high and T2-low...
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Modeling the enigma of complex disease etiology
BackgroundComplex diseases often present as a diagnosis riddle, further complicated by the combination of multiple phenotypes and diseases as...
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Serum IL-5, POSTN and IL-33 levels in chronic rhinosinusitis with nasal polyposis correlate with clinical severity
BackgroundChronic rhinosinusitis (CRS) is a group of heterogeneous diseases characterized by epithelial inflammation and tissue eosinophilic...
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Pharmacometabolomics of Asthma as a Road Map to Precision Medicine
Pharmacometabolomics applies the principles of metabolomics to therapeutics in order to elucidate the biological mechanisms underlying the variation...
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ILCs and Allergy
The recent discovery of new innate lymphoid cells (ILCs) has revolutionized the field of allergies. Since most allergic diseases induce a type 2...
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Oleoylethanolamide induces eosinophilic airway inflammation in bronchial asthma
Asthma is a chronic eosinophilic inflammatory disease with an increasing prevalence worldwide. Endocannabinoids are known to have immunomodulatory...
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Formyl peptide receptors in the mucosal immune system
Formyl peptide receptors (FPRs) belong to the G protein-coupled receptor (GPCR) family and are well known as chemotactic receptors and pattern...
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Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism
Cysteinyl leukotrienes (cysLTs) facilitate eosinophilic mucosal type 2 immunopathology, especially in aspirin-exacerbated respiratory disease (AERD),...
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Trained immunity in type 2 immune responses
Immunological memory of innate immune cells, also termed “trained immunity”, allows for cross-protection against distinct pathogens, but may also...
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TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases
Repetitive exposure to antigen in chronic infection and cancer drives T cell exhaustion, limiting adaptive immunity. In contrast, aberrant, sustained...
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Can GPCRs Be Targeted to Control Inflammation in Asthma?
Historically, the drugs used to manage obstructive lung diseases (OLDs), asthma, and chronic obstructive pulmonary disease (COPD) either (1) directly...
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Integrative information theoretic network analysis for genome-wide association study of aspirin exacerbated respiratory disease in Korean population
BackgroundAspirin Exacerbated Respiratory Disease (AERD) is a chronic medical condition that encompasses asthma, nasal polyposis, and...
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Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa
Increased IgE is a typical feature of allergic rhinitis. Local class-switch recombination has been intimated but B cell precursors and mechanisms...
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Nonsteroidal Anti-inflammatory Drugs
NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) are the most widely used medicines globally. NSAIDs relieve pain (analgesic effect) and fever...
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Druggable Prostanoid Pathway
Prostanoids (prostaglandins, prostacyclin and thromboxane) belong to the oxylipin family of biologically active lipids generated from arachidonic...
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Drugs for the Treatment of Airway Disease
Both ASTHMA and CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) are characterized by airflow obstruction and chronic inflammation of the lower airways,...
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Unraveling obscurins in heart disease
Obscurins, expressed from the single OBSCN gene, are a family of giant, modular, cytoskeletal proteins that play key structural and regulatory roles...
