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Pathological Changes of Small Vessel Disease in Intracerebral Hemorrhage: a Systematic Review and Meta-analysis
In intracerebral hemorrhage (ICH) with pathology-proven etiology, we performed a systematic review and meta-analysis to elucidate the association...
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The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease
Cerebrovascular and α-synuclein pathologies are frequently observed alongside Alzheimer disease (AD). The heterogeneity of AD necessitates...
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Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of...
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A neuropathologic feature of brain aging: multi-lumen vascular profiles
Cerebrovascular pathologies other than frank infarctions are commonly seen in aged brains. Here, we focus on multi-lumen vascular profiles (MVPs),...
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Brain insulin signaling and cerebrovascular disease in human postmortem brain
Insulin is an important hormone for brain function, and alterations in insulin metabolism may be associated with neuropathology. We examined...
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Cortical superficial siderosis is associated with reactive astrogliosis in cerebral amyloid angiopathy
BackgroundCortical superficial siderosis (cSS) has recently emerged as one of the most important predictors of symptomatic intracerebral hemorrhage...
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Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts (RHI) and characterized by...
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Perivascular macrophages produce type I collagen around cerebral small vessels under prolonged hypertension in rats
Hypertension leads to structural remodeling of cerebral blood vessels, which has been implicated in the pathophysiology of cerebrovascular diseases....
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General Considerations
This chapter deals with the basic neuroanatomical facts necessary to understand the human brainstem. It demonstrates the three-dimensional...
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Brain Banking in Dementia Studies
It is now well-established practice in dementia that one clinical entity may be caused by various neurodegenerative disorders, each with different...
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Rhombomere 4 r4
This chapter deals with two important nuclei which provide the transfer of signals from the cerebral cortex to the cerebellum, the pontine nuclei,...
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Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort
In addition to the memory disorders and global cognitive impairment that accompany neurodegenerative diseases, behavioral and psychological symptoms...
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Histopathology of Cerebral Microinfarcts and Microbleeds in Spontaneous Intracerebral Hemorrhage
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patients with spontaneous intracerebral hemorrhage caused by different vasculopathies, cerebral microinfarcts have the same aspect on MRI and the...
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Cortical microvascular raspberries and ageing: an independent but not exclusive relationship
IntroductionRaspberries are cerebral microvascular formations of unknown origin, defined as three or more transversally sectioned vascular lumina...
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Serum soluble LYVE1 is a promising non-invasive biomarker of renal fibrosis: a population-based retrospective cross-sectional study
Diagnosis of renal fibrosis can only be verified by kidney biopsy, but biomarkers for non-invasive evaluation remain unsatisfactory. Patients with...
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Lecture 20: Anatomy, Structure and Function of Blood Vessels
There are three types of blood vessels: arteries, veins and capillaries. Arteries carry blood away from the heart while veins carry blood to the...
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Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states
Vascular risk factors such as chronic hypertension are well-established major modifiable factors for the development of cerebral small vessel disease...
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HIV Promotes Neurocognitive Impairment by Damaging the Hippocampal Microvessels
Current evidence suggests that mild cerebrovascular changes could induce neurodegeneration and contribute to HIV-associated neurocognitive disease...
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AI-based differential diagnosis of dementia etiologies on multimodal data
Differential diagnosis of dementia remains a challenge in neurology due to symptom overlap across etiologies, yet it is crucial for formulating...
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Neurobiological Mechanisms of Cognitive Decline Correlated with Brain Aging
Cognitive decline has emerged as one of the greatest health threats of old age. Meanwhile, aging is the primary risk factor for Alzheimer’s disease...