Search
Search Results
-
Access to quality-assured artemisinin-based combination therapy and associated factors among clients of selected private drug outlets in Uganda
BackgroundMalaria treatment in sub-Saharan Africa is faced with challenges including unreliable supply of efficacious agents, substandard medicines...
-
Network pharmacology-based strategy to investigate the mechanisms of artemisinin in treating primary Sjögren’s syndrome
ObjectiveThe study aimed to explore the mechanism of artemisinin in treating primary Sjögren’s syndrome (pSS) based on network pharmacology and...
-
Experiences of healthcare personnel on the efficacy of artemisinin-based combination therapy and malaria diagnosis in hospitals in Uganda
BackgroundThe risk of widespread resistance to artemisinin-based combination therapy (ACT) remains high in Uganda following detection of Plasmodium...
-
Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice
BackgroundNeuronal ferroptosis plays a critical role in the pathogenesis of cognitive deficits. The present study explored whether artemisinin...
-
Ester tethered artemisinin-isatin hybrids: design, synthesis and anti-leukemic activity evaluation
A series of novel artemisinin-isatin hybrids ( 7a-t ) linked via different lengths of esters were designed, synthesized and evaluated for their...
-
Artemisinin derivative SM934 in the treatment of autoimmune and inflammatory diseases: therapeutic effects and molecular mechanisms
Artemisinin and its derivatives are the well-known anti-malarial drugs derived from a traditional Chinese medicine. In addition to antimalarial,...
-
Pharmacopeial quality of artemether–lumefantrine anti-malarial agents in Uganda
BackgroundSubstandard anti-malarial agents pose a significant challenge to effective malaria control and elimination efforts especially in...
-
Novel Plasmodium falciparum k13 gene polymorphisms from Kisii County, Kenya during an era of artemisinin-based combination therapy deployment
BackgroundCurrently, chemotherapy stands out as the major malaria intervention strategy, however, anti-malarial resistance may hamper global...
-
Co-delivery of artemisinin and metformin via PEGylated niosomal nanoparticles: potential anti-cancer effect in treatment of lung cancer cells
PurposeDespite the advances in treatment, lung cancer is a global concern and necessitates the development of new treatments. Biguanides like...
-
Natural Products as Antiparasitic, Antifungal, and Antibacterial Agents
The estimated age of 26.7 billion years of the universe was insufficient to explore its mysteries and hidden possibilities. As soon as humanity...
-
Repurposing artemisinins as neuroprotective agents: a focus on the PI3k/Akt signalling pathway
Artemisinin and its derivatives, since their discovery by professor Tu Youyou in the early 1970s, have been the bedrock for the management of malaria...
-
Natural Immunomodulatory Agents as a Complementary Therapy for Poxviruses
PoxvirusesPoxviruses target innate immunity mediators such as tumor necrosis factors, interleukins, interferons, complement, and chemokines. It also...
-
Dihydroartemisinin, an active metabolite of artemisinin, interferes with Leishmania braziliensis mitochondrial bioenergetics and survival
Leishmaniasis is one of the most neglected parasitic infections of the world and current therapeutic options show several limitations. In the search...
-
Unlocking therapeutic potential: exploring indole scaffolds and their structural insights as pharmacophores in designing anti-breast cancer agents
Indole scaffolds are well-documented for their biological accessibility and broader therapeutic applications. The cellular interaction of the indole...
-
Defining the next generation of severe malaria treatment: a target product profile
BackgroundSevere malaria is a life-threatening infection, particularly affecting children under the age of 5 years in Africa. Current treatment with...
-
Biomarkers of the Toxic Effects of Chemotherapeutic Agents: A Focus on Antimalarials
Malaria continues to inflict unacceptably high levels of sickness and mortality, as reported in the previous editions of the World Malaria Report....
-
Biomarkers of the Toxic Effects of Chemotherapeutic Agents: A Focus on Antimalarials
Malaria continues to inflict unacceptably high levels of sickness and mortality, as reported in the previous editions of the World Malaria Report....
-
1,2,3-triazenes and 1,2,3-triazoles as antileishmanial, antitrypanosomal, and antiplasmodial agents
Trypanosomiasis, leishmaniasis, and malaria are tropical diseases that affect poor populations and the commonly-used drugs are toxic and can be...
-
Terpenoids as Chemopreventive Agents and Their Interpretation in Animal Models and Human Clinical Trials
Cancer chemoprevention is described as the utilization of substances of natural or synthetic origin to interfere in the discrete early stages of...
-
Association of G6PD status and haemolytic anaemia in patients receiving anti-malarial agents: a systematic review and meta-analysis
BackgroundSome anti-malarial drugs often cause haemolytic anaemia in glucose-6-phosphate-dehydrogenase deficiency (G6PDd) patients. This study aims...
