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Triple artemisinin-based combination therapy (TACT): advancing malaria control and eradication efforts
This paper examines the far-reaching implications of Triple Artemisinin-Based Combination Therapy (TACT) in the global battle against malaria....
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Experiences of healthcare personnel on the efficacy of artemisinin-based combination therapy and malaria diagnosis in hospitals in Uganda
BackgroundThe risk of widespread resistance to artemisinin-based combination therapy (ACT) remains high in Uganda following detection of Plasmodium...
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Strategies for deploying triple artemisinin-based combination therapy in the Greater Mekong Subregion
BackgroundThis is a qualitative study to identify implementation challenges for deploying triple artemisinin-based combination therapy (TACT) in the...
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Exploring the feasibility of introducing triple artemisinin-based combination therapy in the malaria treatment policy in Vietnam
BackgroundThis study investigates the processes regarding changing malaria treatment policies in Vietnam. Moreover, it explores the feasibility of...
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Access to quality-assured artemisinin-based combination therapy and associated factors among clients of selected private drug outlets in Uganda
BackgroundMalaria treatment in sub-Saharan Africa is faced with challenges including unreliable supply of efficacious agents, substandard medicines...
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Factors influencing patients’ adherence to malaria artemisinin-based combination therapy in Kamuli District, Uganda
BackgroundPatients’ adherence to artemisinin-based combination therapy (ACT) is a malaria control strategy. Studies report varied experiences...
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Plasmodium falciparum kelch13 polymorphisms identified after treatment failure with artemisinin-based combination therapy in Niger
BackgroundArtemisinin-based combination therapy (ACT) is the most effective treatment for malaria, and has significantly reduced morbimortality....
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Artemisinin Resistance in Plasmodium falciparum Malaria
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in recent years to a substantial reduction in deaths resulting...
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Novel Plasmodium falciparum k13 gene polymorphisms from Kisii County, Kenya during an era of artemisinin-based combination therapy deployment
BackgroundCurrently, chemotherapy stands out as the major malaria intervention strategy, however, anti-malarial resistance may hamper global...
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Absence of Plasmodium falciparum artemisinin resistance gene mutations eleven years after the adoption of artemisinin-based combination therapy in Nigeria
BackgroundThe occurrence of artemisinin resistance (ART)-associated polymorphism of Plasmodium falciparum K13-propeller ( pfk13 ) gene before and...
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Persistence of Plasmodium falciparum HRP-2 antigenaemia after artemisinin combination therapy is not associated with gametocytes
BackgroundIn some settings, sensitive field diagnostic tools may be needed to achieve elimination of falciparum malaria. To this end, rapid...
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The prevalence of Pfk13 polymorphism in malaria patients treated with artemisinin-based therapy: a systematic review and meta-analysis
Artemisinin (ART) combination therapy is the main treatment for malaria. Pfk13 mutations (or K13 mutations, Kelch 13) are associated with ART...
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Healthcare provider and drug dispenser knowledge and adherence to guidelines for the case management of malaria in pregnancy in the context of multiple first-line artemisinin-based combination therapy in western Kenya
BackgroundConcerns about emerging resistance to artemether-lumefantrine (AL) in Africa prompted the pilot introduction of multiple first-line...
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Molecular markers of artemisinin resistance during falciparum malaria elimination in Eastern Myanmar
BackgroundArtemisinin resistance in Plasmodium falciparum threatens global malaria elimination efforts. To contain and then eliminate artemisinin...
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The impact of anti-malarial markets on artemisinin resistance: perspectives from Burkina Faso
BackgroundWidespread artemisinin resistance in Africa could be catastrophic when drawing parallels with the failure of chloroquine in the 1970s and...
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Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Mali: a systematic review and meta-analysis
BackgroundArtemisinin-based combination therapy (ACT) was deployed in 2005 as an alternative to chloroquine and is considered the most efficacious...
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Emergence of Plasmodium falciparum strains with artemisinin partial resistance in East Africa and the Horn of Africa: is there a need to panic?
The emergence and spread of artemisinin partial resistance in East and Horn of Africa is alarming. However, artemisinin-based combination therapy...
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Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations
Malaria remains a major cause of morbidity and mortality in Africa, particularly in children under five years of age. Availability of effective...
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Modeling policy interventions for slowing the spread of artemisinin-resistant pfkelch R561H mutations in Rwanda
Artemisinin combination therapies (ACTs) are highly effective at treating uncomplicated Plasmodium falciparum malaria, but the emergence of the new pfkelch13...
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Molecular surveillance for polymorphisms associated with artemisinin-based combination therapy resistance in Plasmodium falciparum isolates collected in Mozambique, 2018
BackgroundDue to the threat of emerging anti-malarial resistance, the World Health Organization recommends incorporating surveillance for molecular...
