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Diffuse argyrophilic grain disease with TDP-43 proteinopathy and neuronal intermediate filament inclusion disease: FTLD with mixed tau, TDP-43 and FUS pathologies
Frontotemporal lobar degeneration (FTLD) is a group of disorders characterized by degeneration of the frontal and temporal lobes, leading to...
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Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease
Alzheimer’s disease (AD), characterized by the deposition of amyloid-β (Aβ) in senile plaques and neurofibrillary tangles of phosphorylated tau...
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Argyrophilic grain disease is common in older adults and may be a risk factor for suicide: a study of Japanese forensic autopsy cases
BackgroundNeuropathological diagnosis of argyrophilic grain disease (AGD) is currently based primarily on the combination of argyrophilic grain (AG)...
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Sha** the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models
The transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of Alzheimer's disease and...
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The Spectrum of Tau Pathology in Human Prion Disease
Intracellular deposition of hyperphosphorylated tau characterizes tauopathies: there is a spectrum from neuron-predominant through mixed neuronal and...
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Pretectum p1 (Prosomere 1)
Structures dealt with in this chapter according to genoarchitectonical reasons no longer can be summarized under the term brainstem (Watson et al.,...
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Neuritic Plaques — Gateways to Understanding Alzheimer’s Disease
Extracellular deposits of amyloid-β (Aβ) in the form of plaques are one of the main pathological hallmarks of Alzheimer’s disease (AD). Over the...
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Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels
BackgroundAdvances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma has enabled the use of blood tests to measure Alzheimer’s...
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Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseases
Recent studies suggest that increased cerebrospinal fluid (CSF) phospho-tau is associated with brain amyloid pathology rather than the tau pathology....
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Sporadic Creutzfeldt-Jakob disease VM1: phenotypic and molecular characterization of a novel subtype of human prion disease
The methionine (M)—valine (V) polymorphic codon 129 of the prion protein gene ( PRNP ) plays a central role in both susceptibility and phenotypic...
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Pathogenesis of Alzheimer’s Disease
Alzheimer’s disease (AD) is a clinically progressive decline in cortical function involving memory and other cognitive domain of executive function...
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Axonal degeneration in the anterior insular cortex is associated with Alzheimer’s co-pathology in Parkinson’s disease and dementia with Lewy bodies
BackgroundAxons, crucial for impulse transmission and cellular trafficking, are thought to be primary targets of neurodegeneration in Parkinson’s...
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Comparison of Neuroinflammation Induced by Hyperphosphorylated Tau Protein Versus Ab42 in Alzheimer’s Disease
Both neurofibrillary tangles and senile plaques are associated with inflammation in Alzheimer’s disease (AD). Their relative degree of induced...
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Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing
Neurodegenerative disorders exhibit considerable clinical heterogeneity and are frequently misdiagnosed. This heterogeneity is often neglected and...
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Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targeting
Tauopathies are neurodegenerative diseases that typically require postmortem examination for a definitive diagnosis. Detecting neurotoxic tau...
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Alternative splicing in neurodegenerative disease and the promise of RNA therapies
Alternative splicing generates a myriad of RNA products and protein isoforms of different functions from a single gene. Dysregulated alternative...
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LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease
It has become evident that Alzheimer’s Disease (AD) is not only linked to its hallmark lesions—amyloid plaques and neurofibrillary tangles (NFTs)—but...
