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Detection of MicroRNAs Released from Argonautes
The Argonaute (AGO) family of proteins plays an essential role in the process of microRNA (miRNA)-mediated gene silencing. More specifically, they...
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Characterization of tumor microenvironment and tumor immunology based on the double-stranded RNA-binding protein related genes in cervical cancer
BackgroundCervical cancer is one of the most common gynecological cancers threatening women’s health worldwide. Double-stranded RNA-binding proteins...
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Inhibitors of bacterial immune systems: discovery, mechanisms and applications
To contend with the diversity and ubiquity of bacteriophages and other mobile genetic elements, bacteria have developed an arsenal of immune defence...
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How germ granules promote germ cell fate
Germ cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their ability to assemble...
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tRF3008A suppresses the progression and metastasis of colorectal cancer by destabilizing FOXK1 in an AGO-dependent manner
BackgroundtRNA-derived fragments (tRFs) have been shown to have critical regulatory roles in cancer biology. However, the contributions of tRFs to...
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Bacterial origins of human cell-autonomous innate immune mechanisms
The cell-autonomous innate immune system enables animal cells to resist viral infection. This system comprises an array of sensors that, after...
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Small Noncoding RNA, microRNA in Gene Regulation
A large portion of the human genome is devoted to producing noncoding RNA. A majority of ncRNA are involved in complex regulatory networks that...
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CD95/Fas ligand mRNA is toxic to cells through more than one mechanism
CD95/Fas ligand (CD95L) induces apoptosis through protein binding to the CD95 receptor. However, CD95L mRNA also induces toxicity in the absence of...
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Immunity in Invertebrates, Plants, and Prokaryotes
Vertebrates are not the only organisms with well-developed immune systems. Practically all organisms have some form of innate immunity, and many have...
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The Role of Tertiary Structure in MicroRNA Target Recognition
Translational repression and degradation of transcripts by microRNAs (miRNAs) is mediated by a ribonucleoprotein complex called the miRNA-induced...
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More than causing (epi)genomic instability: emerging physiological implications of transposable element modulation
Transposable elements (TEs) initially attracted attention because they comprise a major portion of the genomic sequences in plants and animals. TEs...
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Role of tRNAs in Breast Cancer Regulation
Increased proliferation and protein synthesis are characteristics of transformed and tumor cells. Although the components of the translation...
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Soma-to-germline RNA communication
More than a century ago, August Weissman defined a distinction between the germline (responsible for propagating heritable information from...
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Effect of asymptomatic infection with southern tomato virus on tomato plants
Southern tomato virus (STV) is often found infecting healthy tomato plants ( Solanum lycopersicum ). In this study, we compared STV-free and...
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PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence transposable elements, regulate gene expression and fight viral...
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Hitching a Ride: Enhancing Nucleic Acid Delivery into Target Cells Through Nanoparticles
Nucleic acids have gained significant interest in medicine for their therapeutic and prophylactic application. However, if delivered alone, nucleic...
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Contribution of Retrotransposable Elements to Aging
Retrotransposable elements (RTEs) are abundant in the genomes of most species and continue to evolve and adapt to the defense mechanisms of their...
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The effects of potato virus Y-derived virus small interfering RNAs of three biologically distinct strains on potato (Solanum tuberosum) transcriptome
BackgroundPotato virus Y (PVY) is one of the most economically important pathogen of potato that is present as biologically distinct strains. The...
