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Glycyrrhiza polysaccharides inhibits PRRSV replication
Glycyrrhiza polysaccharide (GCP) is a natural plant active polysaccharide extracted from traditional Chinese medicine licorice. In this research, we...
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The long non-coding RNA LNC_000397 negatively regulates PRRSV replication through induction of interferon-stimulated genes
BackgroundPorcine reproductive and respiratory syndrome virus (PRRSV) is one of the most significant threats to the global swine industry. It is of...
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Andrographolide and Its Derivative Potassium Dehydrographolide Succinate Suppress PRRSV Replication in Primary and Established Cells via Differential Mechanisms of Action
Porcine reproductive and respiratory syndrome virus (PRRSV) continues to cause significant economic loss worldwide and remains a serious threat to...
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Cell-penetrating porcine single-chain antibodies (transbodies) against nonstructural protein 1β (NSP1β) of porcine reproductive and respiratory syndrome virus inhibit virus replication
Porcine reproductive and respiratory syndrome virus (PRRSV) causes porcine reproductive and respiratory syndrome (PRRS) worldwide, especially in...
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Role of zinc metalloprotease (ZMPSTE24) in porcine reproductive and respiratory syndrome virus (PRRSV) replication in vitro
The transmembrane zinc metalloprotease ZMPSTE24 works in cooperation with interferon-induced transmembrane protein 3 (IFITM3) to restrict entry of...
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The effect of matrine and glycyrrhizic acid on porcine reproductive and respiratory syndrome virus in Vitro and in vivo
Porcine reproductive and respiratory syndrome (PRRS) is endemic worldwide, seriously affecting the development of the pig industry, but vaccines have...
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In vitro suppression of porcine epidemic diarrhea virus by Panax notoginseng saponins: assessing antiviral potential
Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and high mortality in neonatal suckling piglets, leading to significant economic losses...
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Evaluating anti-viral effect of Tylvalosin tartrate on porcine reproductive and respiratory syndrome virus and analyzing the related gene regulation by transcriptomics
BackgroundPorcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen, characterized by its genetic and...
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MiR-339-5p inhibits replication of porcine reproductive and respiratory syndrome virus by targeting viral gene regions
Porcine reproductive and respiratory syndrome virus (PRRSV) is a variable virus, whose spread cannot be totally stopped by vaccination. PRRSV...
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AMP-activated kinase regulates porcine reproductive and respiratory syndrome virus infection in vitro
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen in the pig industry worldwide. Many viruses...
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Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing
A harmonized balance between positive and negative regulation of pattern recognition receptor (PRR)-initiated immune responses is required to achieve...
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Antivirals: Approaches and the Way Forward
Viral diseases pose significant challenges in human and veterinary medicine, as effective treatment options are limited. The development of antiviral...
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Integrative analysis of microRNA and mRNA expression profiles in MARC-145 cells infected with PRRSV
Porcine reproductive and respiratory syndrome virus (PRRSV) causes tremendous economic losses to the swine industry worldwide. miRNAs are crucial...
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Exploring Medicinal Plant Resources for Combating Viral Diseases, Including COVID-19
This book chapter provides insight into the medicinal plant extracts and phytochemicals essential to combat several viral diseases, including...
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Aloe-emodin inhibits African swine fever virus replication by promoting apoptosis via regulating NF-κB signaling pathway
African swine fever (ASF) is an acute infectious haemorrhagic fever of pigs caused by African swine fever virus (ASFV). Aloe-emodin (Ae) is an active...
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Role and clinical implication of autophagy in COVID-19
The ongoing coronavirus disease 2019 (COVID-19) pandemic constitutes a serious public health concern worldwide. Currently, more than 6 million deaths...
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Antiviral activity of Piscidin 1 against pseudorabies virus both in vitro and in vivo
BackgroundSwine-origin virus infection spreading widely could cause significant economic loss to porcine industry. Novel antiviral agents need to be...
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Application of a recombinant replicase to localize the Trionyx sinensis hemorrhagic syndrome virus and evaluate its effects on antiviral genes of T. sinensis
Trionyx sinensis Hemorrhagic Syndrome Virus (TSHSV) is an arterivirus newly discovered in Chinese softshell turtles. Little is known about the effect...
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The prevention strategies of swine viruses related to xenotransplantation
Xenotransplantation is considered a solution for the shortage of organs, and pigs play an indispensable role as donors in xenotransplantation. The...
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In vitro antiviral activity of Griffithsin against porcine epidemic diarrhea virus
Griffithsin is a lectin with potent antiviral activity against enveloped viruses. The objective of this study was to assess Griffithsin’s inhibitory...
