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Risk of renal impairment in atypical antipsychotics: a systematic review and meta-analysis
PurposeAtypical antipsychotics are associated with several adverse effects including metabolic syndrome, weight gain, QTc interval prolongation, and...
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Antipsychotics and risk of QT prolongation: a pharmacovigilance study
RationaleWhile meta-analyses of clinical trials found that lurasidone and partial dopamine agonists (brexpiprazole and aripiprazole) were the...
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Withdrawal syndrome after antipsychotics discontinuation: an analysis of the WHO database of spontaneous reports (Vigibase) between 2000 and 2022
RationaleWithdrawal syndrome (WDS) has been described after discontinuation of antipsychotics. WDS could be the consequence of an over-activation of...
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Long-term second-generation antipsychotics decreases bone formation and resorption in male patients with schizophrenia
RationalePatients with schizophrenia with second-generation antipsychotics (SGAs) treatment have shown an increased risk of bone fragility and...
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Atypical antipsychotics attenuate MK801-induced social withdrawal and hyperlocomotion in the RHA rat model of schizophrenia-relevant features
RationaleThe administration of NMDA receptor (NMDAR) antagonists constitutes a widely used model that produce both positive (e.g., hyperactivity) and...
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TNIK influence the effects of antipsychotics on Wnt/β-catenin signaling pathway
Rationale
Traf2- and Nck-interacting kinase (TNIK), a member of germinal center kinase (GCK) family, has been implicated as a risk factor in...
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Utilizing questionnaires for medication counselling of patients taking antipsychotics during the COVID-19 pandemic: a single site, community pharmacy-based survey study
BackgroundDuring the coronavirus disease (COVID-19) pandemic, general strategies for preventing infectious diseases, such as social distancing and...
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Effect of Novel Antipsychotics on Energy Metabolism — In Vitro Study in Pig Brain Mitochondria
The identification and quantification of mitochondrial effects of novel antipsychotics (brexpiprazole, cariprazine, loxapine, and lurasidone) were...
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Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP3A4 and CYP1A2 and antipsychotics
The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate pharmacogenetics implementation in clinical practice by develo** evidence-based...
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From GWAS to drug screening: repurposing antipsychotics for glioblastoma
BackgroundGlioblastoma is currently an incurable cancer. Genome-wide association studies have demonstrated that 41 genetic variants are associated...
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Incidence of hospital contacts with acute kidney injury after initiation of second-generation antipsychotics in older adults: a Danish population-based cohort study
PurposeTo investigate the association between acute kidney injury (AKI) and use of second-generation antipsychotics (SGA) in older adults.
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Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes
Most studies of gene expression in the brains of individuals with schizophrenia have focused on cortical regions, but subcortical nuclei such as the...
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Pediatric Methamphetamine Toxicity: Clinical Manifestations and Therapeutic Use of Antipsychotics—One Institution’s Experience
IntroductionMethamphetamine toxicity is common in the Southwest region of the United States and presents diagnostic and treatment challenges in the...
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Effect of antipsychotics on breast tumors by analysis of the Japanese Adverse Drug Event Report database and cell-based experiments
BackgroundSince antipsychotics induce hyperprolactinemia via the dopamine D 2 receptor, long-term administration may be a risk factor for develo**...
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Drug-drug interactions between COVID-19 treatments and antipsychotics drugs: integrated evidence from 4 databases and a systematic review
RationaleManagement of anxiety, delirium, and agitation cannot be neglected in coronavirus disease (COVID-19). Antipsychotics are usually used for...
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Antipsychotics Induced Movement and Sleep Disorder on Patients with Schizophrenia Attending Follow-Up Service
BackgroundAntipsychotics medication has unwanted effects which occurred during the initiation and withdrawal of neuroleptics. It results in poor...
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Serum concentrations of antidepressants, antipsychotics, and antiepileptics over the bariatric surgery procedure
PurposeAs a substantial proportion of bariatric surgery patients use psychotropic/antiepileptic drugs, we investigated the impact of this procedure...
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Antipsychotics
Name: Aripiprazole