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Malaria Drug Discovery: How to Tackle the Problem of Drug Resistance
Malaria has been a huge issue in previous years since it is an endemic disease that kills millions of people worldwide, regardless of their age....
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A candidate antibody drug for prevention of malaria
Over 75% of malaria-attributable deaths occur in children under the age of 5 years. However, the first malaria vaccine recommended by the World...
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Dissecting the low morbidity and mortality during the COVID-19 pandemic in Africa: a critical review of the facts and fallacies
Except for South Africa, Africa recorded very low cases of coronavirus disease-19 (COVID-19), and even lower deaths compared to other regions of the...
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Biomarkers of the Toxic Effects of Chemotherapeutic Agents: A Focus on Antimalarials
Malaria continues to inflict unacceptably high levels of sickness and mortality, as reported in the previous editions of the World Malaria Report....
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Biomarkers of the Toxic Effects of Chemotherapeutic Agents: A Focus on Antimalarials
Malaria continues to inflict unacceptably high levels of sickness and mortality, as reported in the previous editions of the World Malaria Report....
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Evolution of genetic markers for drug resistance after the introduction of dihydroartemisinin–piperaquine as first-line anti-malarial treatment for uncomplicated falciparum malaria in Indonesia
BackgroundDihydroartemisinin–piperaquine has been Indonesia’s first-line anti-malarial treatment since 2008. Annual therapeutic efficacy studies...
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Repurposing artemisinins as neuroprotective agents: a focus on the PI3k/Akt signalling pathway
Artemisinin and its derivatives, since their discovery by professor Tu Youyou in the early 1970s, have been the bedrock for the management of malaria...
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A review of Cameroonian medicinal plants with potentials for the management of the COVID-19 pandemic
Since the outbreak in December 2019, in Wuhan (China) of COVID-19, approved drugs are still lacking and the world is seeking effective treatment. The...
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Ethnopharmacological survey of aromatic medicinal plants used in the treatment of the most recurrent diseases in the locality of Oyem, Gabon
Aromatic medicinal plants are a great source of active principles that can be used to treat several diseases. The objective of this study was to...
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Traditional uses, phytochemical and pharmacological properties of Feretia apodanthera Del. (Rubiaceae): a literature review
Feretia apodanthera Delile (Rubiaceae) is a plant found mainly in tropical Africa. In this region, the different parts of Feretia apodanthera Delile...
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Characteristics of published/registered clinical trials on COVID-19 treatment: A systematic review
ObjectivesDue to the rapid spread of COVID-19 worldwide, many countries have designed clinical trials to find efficient treatments. We aimed to...
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Limitations of Current Drugs and Prospects of Plant-Based Compounds and Their Constructed Analogs as Therapeutics for Treatment of Malaria
Antimalarial drug resistance is persistently posing a major risk for eradicating malaria and is the key challenge for radically curing malaria....
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Inverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study
BackgroundFalciparum and endemic Burkitt lymphoma (eBL) are co-endemic in Africa, but the malaria experience in eBL patients is unknown. A lower...
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Late morning biting behaviour of Anopheles funestus is a risk factor for transmission in schools in Siaya, western Kenya
BackgroundChildren in Kenya spend a substantial amount of time at school, including at dawn and dusk when mosquitoes are active. With changing vector...
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A framework for stakeholder engagement in the adoption of new anti-malarial treatments in Africa: a case study of Nigeria
BackgroundRecent reports of artemisinin partial resistance from Rwanda and Uganda are worrisome and suggest a future policy change to adopt new...
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Future Implications of Desert Malaria in Global Elimination Campaign
Deserts, covering nearly 33% of the earth’s land area (approximately 33.7 million square kilometres) and inhabited by over 500 million people, are...
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Effect of dietary intervention on the prevalence of asymptomatic malaria among 6–18-month-old children in rural Malawi
BackgroundThe complex interaction between malaria and undernutrition leads to increased mortality and morbidity rate among young children in...
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Concluding Thoughts
While advances in drug therapy came fast and furious during the twentieth century, the cost and time required to bring a new drug to market have...
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Evidence of malarial chemoprophylaxis among travellers who died from malaria: a systematic review and meta-analysis
BackgroundChemoprophylaxis is a prevention method for malaria during travel in malaria-endemic countries. This study aimed to collate and synthesize...
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Design, synthesis, molecular docking, antimicrobial, and antioxidant activities of new phenylsulfamoyl carboxylic acids of pharmacological interest
The research explores the facile synthesis of some new phenylsulfamoyl carboxylic acids, their molecular docking, antimicrobial, and antioxidant...
