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Antifungal Susceptibility of Yeasts and Filamentous Fungi by CLSI Broth Microdilution Testing
Antifungal susceptibility testing is performed against yeasts and filamentous fungi (molds) for various purposes. In clinical settings, the results...
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Antifungal Susceptibility Testing and Drug Discovery in the Dimorphic Fungus Histoplasma Capsulatum
The thermal dimorphism of the fungal pathogen Histoplasma is linked to its virulence in mammalian hosts. Mammalian body temperature triggers...
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Antifungal Susceptibility Testing of Dermatophytes
In order to help guide treatment, antifungal susceptibility testing is often performed in clinical microbiology laboratories. The results of these in...
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New Antifungal Drugs: Discovery and Therapeutic Potential
There has been an increase in invasive fungal infections, which are a universal problem due to the longer average lifespan, the number of...
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Emerging Antifungal Resistance in Fungal Pathogens
Purpose of ReviewOver recent decades, the number of outbreaks caused by fungi has increased for humans, plants (including important crop species) and...
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The Metabolism of Susceptibility: Clearing the FoG Between Tolerance and Resistance in Candida albicans
Purpose of ReviewFailure of antifungal treatment is alarmingly common in patients infected with Candida albicans isolates that test as susceptible...
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Heterologous Expression of Candida Antifungal Target Genes in the Model Organism Saccharomyces cerevisiae
Understanding how a gene variant may influence antifungal resistance, or other phenotypic characteristics, is an important step in determining or...
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Luciferase-Based High-Throughput Screen with Aspergillus fumigatus to Identify Antifungal Small Molecules
Only three classes of contemporary antifungal drugs are routinely utilized in the clinic against filamentous fungal pathogens such as Aspergillus...
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Pulmonary surfactant impacts in vitro activity of selected antifungal drugs against Candida krusei and Candida albicans
PurposeThis study investigates how surfactants affect the in-vitro anti-infective efficacy of micafungin, caspofungin, anidulafungin, and...
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Comparison of in vitro activities of newer triazoles and classic antifungal agents against dermatophyte species isolated from Iranian University Hospitals: a multi-central study
BackgroundDermatophytes have the ability to invade the keratin layer of humans and cause infections. The aims of this study were the accurate...
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Antibacterial, antifungal activities and toxicity of new synthetic fatty acid salicylate esters
Microbial threats and their resistance to the available drugs are public health concerns that scientists worldwide are trying to solve. Before the...
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When to Initiate Antifungal Treatment in COVID-19 Patients with Secondary Fungal Co-infection
Purpose of ReviewSevere-acute respiratory coronavirus 2 (SARS-CoV-2) has been driving the health care delivery system for over 2 years. With time,...
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A longitudinal study of Candida bloodstream infections in a Japanese university hospital: species distribution, drug susceptibility, clinical features, and mortality predictors
We aimed to detect possible changes in Candida species distribution over time and to know the antifungal susceptibility profile of isolates obtained...
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Exploiting response surface D-optimal design study for preparation and optimization of spanlastics loaded with miconazole nitrate as a model antifungal drug for topical application
PurposeSkin fungal infections are widely spreading worldwide and are considered a main cause of skin, mucous membranes, and systemic diseases. In an...
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Population differentiation, antifungal susceptibility, and host range of Trichophyton mentagrophytes isolates causing recalcitrant infections in humans and animals
The major problems in determining the causative factors of the high prevalence of dermatophytoses include the lack of a well-standardized antifungal...
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A Simple Antifungal assay for Testing Actinomycetes and Other Microbial Extracts
Antifungal assay in vitro is a useful tool for the characterization of biological activity of microbial extracts. Here we describe a simple in vitro...
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Change in species distribution and antifungal susceptibility of candidemias in an intensive care unit of a university hospital (10-year experience)
Candidemia is a nosocomial infection mostly found in critically ill patients. Our objectives were to evaluate the change in distribution and...
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Antifungal Drugs: Mechanism of Action and Resistance
Overuse of antifungal drugs in recent years has developed resistance against these drugs. The significant clinical influence of resistance has...
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New Antifungal Agents and New Formulations Against Dermatophytes
There are a plethora of antifungal agents available for the treatment of onychomycosis. Systemic antifungal drugs are generally recommended for...
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Deletion of both Dectin-1 and Dectin-2 affects the bacterial but not fungal gut microbiota and susceptibility to colitis in mice
BackgroundInnate immunity genes have been reported to affect susceptibility to inflammatory bowel diseases (IBDs) and colitis in mice. Dectin-1, a...
