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The Central Effects of Peripherally Administered Immune Cells Modulated by an Original Anticonvulsant in Experimental Alcoholism
Abstract —Disruption of neuroimmune regulatory relationships caused by a change in the functional phenotype of immune cells due to chronic ethanol...
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Possible Interaction of Opioidergic and Nitrergic Pathways in the Anticonvulsant Effect of Ivermectin on Pentylenetetrazole-Induced Clonic Seizures in Mice
Ivermectin (IVM) is an antiparasitic drug that primarily works by the activation of GABA A receptors. The potential pharmacological pathways behind...
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Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies
Epilepsy, a chronic neurological condition, impacts millions of individuals globally and remains a significant contributor to both illness and...
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Participation of Brain Receptors in the Mechanism of Anticonvulsant Action of the New 4-Benzoylpyridine Oxime Derivative GIZH-298
Abstract —The aim of this work was to study the involvement of the glutamate, dopamine, and serotonin receptors in the mechanism of the anticonvulsant...
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Design, synthesis, and pharmacological evaluation of aryl oxadiazole linked 1,2,4-triazine derivatives as anticonvulsant agents
A series of new clubbed aryl oxadiazole-1,2,4-triazine derivatives (6a-l) were designed and synthesized using appropriate chemical routes. The...
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Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio)
Epilepsy is a common neurological disorder which affects 50 million people worldwide. Patients with epilepsy may present cognitive deficits and...
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Chemical composition and anticonvulsant activities of herb pair of Gastrodia elata Blume-Acorus tatarinowii Schott decoction on experimentally induced seizures in mice
Epilepsy is a serious public health problem in the world. At present, over 30% of affected patients remain refractory to currently available...
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N-Formyl-Methionyl-Leucyl-Phenylalanine Plays a Neuroprotective and Anticonvulsant Role in Status Epilepticus Model
Status epilepticus (SE) is described as continuous and self-sustaining seizures, which triggers hippocampal neurodegeneration, inflammation, and...
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Anticonvulsant Effects of Royal Jelly in Kainic Acid-Induced Animal Model of Temporal Lobe Epilepsy Through Antioxidant Activity
Temporal lobe epilepsy (TLE) is the most common form of partial and drug-resistant epilepsy, characterized by recurrent seizures originating from...
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Anticonvulsant activity of methanolic extract of Withania cogulans in mice
Mental and neurological diseases including depression, Parkinson’s disease, dementia, epilepsy, anxiety disorders and bipolar disorders account for a...
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The effect of a novel anticonvulsant chemical Q808 on gut microbiota and hippocampus neurotransmitters in pentylenetetrazole-induced seizures in rats
BackgroundThe gut microbiota can modulate brain function and behavior and is increasingly recognized as an important factor in mediating the risk of...
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Cognitive Impairment and Nootropic Drugs: Mechanism of Action and Spectrum of Effects
Abstract —This review provides information about the features of cognitive dysfunctions that occur in various diseases and conditions, and data on the...
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Investigation on the Anticonvulsant Potential of Luteolin and Micronized Luteolin in Adult Zebrafish (Danio rerio)
Epilepsy affects around 50 million people worldwide, and an important number of patients (30%) fail to respond to any available antiepileptic drug....
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Pharmacological Profile of FDA-Approved Orphan Drugs in the Year 2022
Purpose of ReviewThis manuscript aimed to provide a scientific report of recently FDA-approved orphan drugs for hel** patients, researchers,...
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A review on the synthesis and applications of molecules as anticonvulsant drug agent candidates
Epilepsy is one of the most common neurological disorders worldwide and it requires a long-term or life-long treatment. Current standard treatment...
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Anticonvulsant effect of pterostilbene and its influence on the anxiety- and depression-like behavior in the pentetrazol-kindled mice: behavioral, biochemical, and molecular studies
RationalePterostilbene is the 3,5-dimethoxy derivative of resveratrol with numerous beneficial effects including neuroprotective properties....
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Anticonvulsant Effect of Asparagus racemosus Willd. in a Mouse Model of Catamenial Epilepsy
Asparagus racemosus Willd. (Family Liliaceae), also known as female reproductive tonic, is traditionally used across the Sub-Himalayan region in...
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Repurposing Marketed Drugs as Antidepressants with In Silico, In Vivo, and In Vitro Screening Methods
Drug repurposing is a strategy to identify new therapeutic uses for marketed drugs, discontinued or shelved drugs, and drug candidates in clinical...
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Screening Methods for the Evaluation of Antiepileptic Drugs
Seizure is sudden disorganized uncontrolled electrical activity in the brain, leading to alteration of behaviors, movement, or level of...