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Cholinergic Functioning, Cognition, and Anticholinergic Medication Burden in Schizophrenia
Acetylcholine (ACh) signaling is critical for central nervous function and is known to be abnormal in schizophrenia (SZ), a chronic neuropsychiatric...
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Anticholinergic burden and cognitive performance: cross-sectional results from the ELSA-Brasil study
ObjectivesUsing multiple drugs with anticholinergic properties is common and might lead to cumulative anticholinergic toxicity and increased risk of...
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A meta-analysis of observational studies on anticholinergic burden and fracture risk: evaluation of conventional burden scales
BackgroundAnticholinergic burden potentially increases the risk of fracture. Although there are various anticholinergic burden scales, little is...
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Use of overactive bladder anticholinergic medications associated with falls leading to emergency department visits: results from the ADRED study
PurposeDrug intake might be a modifiable factor for the individual fall-risk of older adults, and anticholinergic properties of drugs need to be...
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Association between anticholinergic activity and xerostomia and/ or xerophthalmia in the elderly: systematic review
PurposeThe aim of this work was to investigate the association between anticholinergic burden or anticholinergic drug use and xerostomia and/or...
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Comparative associations between anticholinergic burden and emergency department visits for anticholinergic adverse events in older Korean adults: a nested case-control study using national claims data for validation of a novel country-specific scale
BackgroundConsidering the limited generalizability of previous anticholinergic burden scales, the Korean Anticholinergic Burden Scale (KABS) as a...
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Quality of anticholinergic burden scales and their impact on clinical outcomes: a systematic review
PurposeOlder people are at risk of anticholinergic side effects due to changes affecting drug elimination and higher sensitivity to drug’s side...
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Anticholinergic load and delirium in end-of-life patients
BackgroundDelirium is a neuropsychiatric syndrome associated with negative outcomes, including worsening of cognitive and functional status and an...
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Association between anticholinergic drug burden and mortality in older people: a systematic review
PurposeThe purpose of the study is to conduct a systematic review of studies examining the association between anticholinergic burden and mortality...
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Patterns of inappropriate prescribing and clinical characteristics in patients at admission to an acute care of the elderly unit
PurposeInappropriate prescribing (IP) is common among the elderly and is associated with adverse health outcomes. The role of different patterns of...
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The association between benzodiazepine use and greater risk of neurocognitive impairment is moderated by medical burden in people with HIV
Benzodiazepine use is linked to neurocognitive impairment (NCI) in the general population and people with HIV (PWH); however, this relationship may...
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Potentially inappropriate medication use and mortality in patients with cognitive impairment
PurposePotentially inappropriate medications (PIMs) are associated with falls, hospitalization, and cognitive decline. Few studies have investigated...
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Association between anticholinergic (atropinic) drug exposure and cognitive function in longitudinal studies among individuals over 50 years old: a systematic review
PurposeWith increasing age, adults are often exposed to anticholinergic drugs and are prone to potential adverse drug reaction, among which cognitive...
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Implementation of clinical medication review in a geriatric ward to reduce potentially inappropriate prescriptions among older adults
PurposeThe impact of several pharmaceutical interventions to reduce the use of potentially inappropriate medications (PIMs) and potentially omitted...
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Pharmacoepidemiology Research Delivering Evidence About Drug Safety in Dementia
Dementia is one of the main causes of dependency and disability in older adults worldwide. Drug safety is important to define in those living with...
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Reliability and validity of the Swedish indicator ‘Drugs that should be avoided in older people’—an appraisal of a set of potentially inappropriate medications
PurposeTo analyse the reliability and validity of the Swedish indicator ‘Drugs that should be avoided in older people’.
MethodsFrom a previous study...
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Utilization of Drug Decision Support Strategies Including Drug Characteristics to Reduce the Risk of Iatrogenesis in Advanced Age
Purpose of ReviewThe goal of this review is to examine currently available risk drug decision support strategies including medication...
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Antidepressant deprescribing: State of the art and recommendations—A literature overview
IntroductionIn recent years, the consumption of antidepressants has arisen. However, deprescribing antidepressant therapy is very complicated. The...
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miR-9-5p is Downregulated in Serum Extracellular Vesicles of Patients Treated with Biperiden After Traumatic Brain Injury
Traumatic brain injury (TBI) is a prevalent and debilitating condition, which often leads to the development of post-traumatic epilepsy (PTE), a...
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Clinical Treatment Available for Schizophrenia
Schizophrenia is a chronic illness which leads to poor quality of life. Disease course and prognosis depend upon the management of schizophrenia. For...