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Use of overactive bladder anticholinergic medications associated with falls leading to emergency department visits: results from the ADRED study
PurposeDrug intake might be a modifiable factor for the individual fall-risk of older adults, and anticholinergic properties of drugs need to be...
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Association between anticholinergic activity and xerostomia and/ or xerophthalmia in the elderly: systematic review
PurposeThe aim of this work was to investigate the association between anticholinergic burden or anticholinergic drug use and xerostomia and/or...
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Anticholinergic burden and cognitive performance: cross-sectional results from the ELSA-Brasil study
ObjectivesUsing multiple drugs with anticholinergic properties is common and might lead to cumulative anticholinergic toxicity and increased risk of...
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Cholinergic Functioning, Cognition, and Anticholinergic Medication Burden in Schizophrenia
Acetylcholine (ACh) signaling is critical for central nervous function and is known to be abnormal in schizophrenia (SZ), a chronic neuropsychiatric...
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A meta-analysis of observational studies on anticholinergic burden and fracture risk: evaluation of conventional burden scales
BackgroundAnticholinergic burden potentially increases the risk of fracture. Although there are various anticholinergic burden scales, little is...
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Anticholinergic load and delirium in end-of-life patients
BackgroundDelirium is a neuropsychiatric syndrome associated with negative outcomes, including worsening of cognitive and functional status and an...
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Comparative associations between anticholinergic burden and emergency department visits for anticholinergic adverse events in older Korean adults: a nested case-control study using national claims data for validation of a novel country-specific scale
BackgroundConsidering the limited generalizability of previous anticholinergic burden scales, the Korean Anticholinergic Burden Scale (KABS) as a...
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Quality of anticholinergic burden scales and their impact on clinical outcomes: a systematic review
PurposeOlder people are at risk of anticholinergic side effects due to changes affecting drug elimination and higher sensitivity to drug’s side...
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Association between anticholinergic drug burden and mortality in older people: a systematic review
PurposeThe purpose of the study is to conduct a systematic review of studies examining the association between anticholinergic burden and mortality...
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The treatment of neurogenic lower urinary tract dysfunction in persons with spinal cord injury: An open label, pilot study of anticholinergic agent vs. mirabegron to evaluate cognitive impact and efficacy
Study designPre–post intervention.
Objectives1. To test whether replacement of oral anticholinergic (AC) agents with mirabegron for neurogenic lower...
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Patterns of inappropriate prescribing and clinical characteristics in patients at admission to an acute care of the elderly unit
PurposeInappropriate prescribing (IP) is common among the elderly and is associated with adverse health outcomes. The role of different patterns of...
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Implementation of clinical medication review in a geriatric ward to reduce potentially inappropriate prescriptions among older adults
PurposeThe impact of several pharmaceutical interventions to reduce the use of potentially inappropriate medications (PIMs) and potentially omitted...
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Association between anticholinergic (atropinic) drug exposure and cognitive function in longitudinal studies among individuals over 50 years old: a systematic review
PurposeWith increasing age, adults are often exposed to anticholinergic drugs and are prone to potential adverse drug reaction, among which cognitive...
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Potentially inappropriate medication use and mortality in patients with cognitive impairment
PurposePotentially inappropriate medications (PIMs) are associated with falls, hospitalization, and cognitive decline. Few studies have investigated...
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Reliability and validity of the Swedish indicator ‘Drugs that should be avoided in older people’—an appraisal of a set of potentially inappropriate medications
PurposeTo analyse the reliability and validity of the Swedish indicator ‘Drugs that should be avoided in older people’.
MethodsFrom a previous study...
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Differences in the incidence of lurasidone adverse events between depressive disorders and schizophrenia in double-blind, randomized, placebo-controlled trials: a meta-analysis
RationaleWe conducted a meta-analysis of double-blind, randomized placebo-controlled trials of lurasidone (LUR) to examine the difference in the risk...
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Pharmacoepidemiology Research Delivering Evidence About Drug Safety in Dementia
Dementia is one of the main causes of dependency and disability in older adults worldwide. Drug safety is important to define in those living with...
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Neurotoxicity evoked by organophosphates and available countermeasures
Organophosphorus compounds (OP) are a constant problem, both in the military and in the civilian field, not only in the form of acute poisoning but...
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Cholinoceptor Antagonists
Ever since the first documented use of the first prototypical anticholinergic drug, atropine in 1554 as mydriatic, modern science has discovered and...
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Screening Methods for the Evaluation of Drugs Acting on Autonomic Nervous System
Autonomic nervous system (ANS) which is maintaining the internal homeostasis, broadly classified into sympathetic and parasympathetic system....