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Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects
Inflammatory activation and oxidative stress promote the proliferation of vascular smooth muscle cells (VSMCs), which accounts for pathological...
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Metabolic activities affect femur and lumbar vertebrae remodeling, and anti-resorptive risedronate disturbs femoral cortical bone remodeling
Metabolic activities are closely correlated with bone remodeling and long-term anti-resorptive bisphosphonate treatment frequently causes atypical...
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Anti-inflammatory, cardioprotective effect of gypenoside against isoproterenol-induced cardiac remodeling in rats via alteration of inflammation and gut microbiota
BackgroundMyocardial infarction (MI), commonly referred to as a heart attack, occurs when the blood flow to a portion of the heart is blocked,...
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Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade
BackgroundAccumulation of Foxp3 + regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a...
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The role and mechanism of heme oxygenase-1 in arrhythmias
The global incidence and prevalence of arrhythmias are continuously increasing. However, the precise mechanisms of underlying arrhythmogenesis and...
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Mesenchymal Stromal Cell Therapy Alleviates Ovalbumin-Induced Chronic Airway Remodeling by Suppressing M2 Macrophage Polarization
Chronic asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Previous studies have shown that mesenchymal...
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Role of Collapsin-Response Mediator Protein 2 in the Development of Epileptic Seizures in Clinics and Experimental Models
Problems of the engagement of collapsin-response mediator protein 2 (CRMP2) in the induction of epileptic seizures and the interrelationship between...
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Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
The malignant tumor is a multi-etiological, systemic and complex disease characterized by uncontrolled cell proliferation and distant metastasis....
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Scutellarin Alleviates Ovalbumin-Induced Airway Remodeling in Mice and TGF-β-Induced Pro-fibrotic Phenotype in Human Bronchial Epithelial Cells via MAPK and Smad2/3 Signaling Pathways
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. Epithelial-mesenchymal...
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Add-on multiple submucosal injections of the RNA oligonucleotide GUT-1 to anti-TNF antibody treatment in patients with moderate-to-severe ulcerative colitis: an open-label, proof-of concept study
BackgroundCarbohydrate sulfotransferase 15 (CHST15) is an enzyme biosynthesizing matrix glycosaminoglycan that modulates tissue remodeling. We...
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Cardiomyocyte-targeting exosomes from sulforaphane-treated fibroblasts affords cardioprotection in infarcted rats
BackgroundExosomes (EXOs), tiny extracellular vesicles that facilitate cell–cell communication, are being explored as a heart failure treatment,...
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Alpha-7 Nicotinic Receptor Agonist Protects Mice Against Pulmonary Emphysema Induced by Elastase
Pulmonary emphysema is a primary component of chronic obstructive pulmonary disease (COPD), a life-threatening disorder characterized by lung...
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Association between insulin resistance and cardiac remodeling in HER2-positive breast cancer patients: a real-world study
BackgroundInsulin resistance is an overlap** risk factor for both heart and breast cancer, while its interaction with cardiotoxicity in breast...
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IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction
Acute myocardial infarction is an important cardiovascular disease worldwide. Although the mortality rate of myocardial infarction (MI) has improved...
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Effect of hypobaric hypoxia on the fiber type transition of skeletal muscle: a synergistic therapy of exercise preconditioning with a nanocurcumin formulation
Hypobaric hypoxia (HH) leads to various adverse effects on skeletal muscles, including atrophy and reduced oxidative work capacity. However, the...
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Role of Stem Cells and Derived Exosomes as Novel Therapeutic Agents against Neuroinflammation and Stroke
Stroke is a disorder resulting predominantly from the rupture or blockage of blood vessels and is the third primary cause of mortality and disability...
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Duloxetine HCl Alleviates Asthma Symptoms by Regulating PI3K/AKT/mTOR and Nrf2/HO-1 Signaling Pathways
Asthma is an inflammatory disease characterized by airway hyperresponsiveness, airway remodeling, and airway inflammation. In recent years, the...
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Local decorin delivery via hyaluronic acid microrods improves cardiac performance, ventricular remodeling after myocardial infarction
Heart failure (HF) remains a global public health burden and often results following myocardial infarction (MI). Following injury, cardiac fibrosis...
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Bioengineering and Bioinformatic Approaches to Study Extracellular Matrix Remodeling and Cancer–Macrophage Crosstalk in the Breast Tumor Microenvironment
Tumor-associated macrophages (TAMs) are one of the most abundant cell types in the breast tumor microenvironment. TAMs are characterized by...
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Roles of cancer-associated fibroblasts (CAFs) in anti- PD-1/PD-L1 immunotherapy for solid cancers
In recent years, breakthroughs have been made in tumor immunotherapy. However, tumor immunotherapy, particularly anti-PD-1/PD-L1 immune checkpoint...
