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Antibodies
Antibodies are globulin proteins (immunoglobulins) that are synthesised in serum and tissue fluids, which react specifically with the antigen that...
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Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
Diagnostic assays currently used to monitor the efficacy of COVID-19 vaccines measure levels of antibodies to the receptor-binding domain of...
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Monoclonal Antibodies in Solid Organ Transplantation
In an attempt to target solid organ transplant immunosuppression, monoclonal antibodies directed against key steps in specific immunologic pathways...
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Monoclonal Antibodies: From Structure to Therapeutic Application
The exciting field of therapeutic monoclonal antibodies (mAbs) had its origins when Köhler and Milstein presented their murine hybridoma technology...
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Neonatal SARS-CoV-2 immunoglobulin G antibodies at delivery and their impact on COVID-19
ObjectiveTo assess neonatal SARS-CoV-2 anti-spike IgG antibody levels after maternal mRNA COVID-19 vaccination and/or infection during pregnancy and...
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Comparative analyses of functional antibody-mediated inhibition with anti-circumsporozoite monoclonal antibodies against transgenic Plasmodium berghei
BackgroundAcquired functional inhibitory antibodies are one of several humoral immune mechanisms used to neutralize foreign pathogens. In vitro...
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Angiotensin II Type 1 Receptor Antibodies Are Higher in Lupus Nephritis and Vasculitis than Other Glomerulonephritis Patients
Angiotensin II type 1 receptor (AT1R) antibodies are considered non-HLA (human leukocyte antigen) antibodies connected with humoral rejection after...
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Simple prediction of COVID-19 convalescent plasma units with high levels of neutralization antibodies
BackgroundHyperimmune convalescent COVID-19 plasma (CCP) containing anti-SARS-CoV-2 neutralizing antibodies (NAbs) was proposed as a therapeutic...
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Detection of Pre-Existing Antibodies to Polyethylene Glycol and PEGylated Liposomes in Human Serum
Polyethylene glycol, or PEG, is common in consumer products, over-the-counter medications, food, and pharmaceutical products. Concerns about PEG...
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Laboratory Testing for Non-criteria Antiphospholipid Antibodies: Antibodies Toward the Domain I of Beta2-Glycoprotein I (aDI)
Anti-β2GPI antibodies (aβ2GPI) are one of the laboratory criteria for antiphospholipid syndrome (APS), along with lupus anticoagulant (LA) and...
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Interaction of Bacteriophages with the Immune System: Induction of Bacteriophage-Specific Antibodies
In all cases when a bacteriophage makes a direct contact with a mammalian organism, it may challenge the mammalian immunological system. Its major...
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Dry Powder Formulation of Monoclonal Antibodies for Pulmonary Delivery
Interest in monoclonal antibody therapy for lung indications has grown substantially in the last decade. Local delivery of monoclonal antibody...
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Generation of Protease Inhibitory Antibodies by Functional In Vivo Selection
Targeting dysregulated protease expression and/or abnormal substrate proteolysis, highly selective inhibition of pathogenic proteases by monoclonal...
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Characterization of antibodies targeting severe fever with thrombocytopenia syndrome virus glycoprotein Gc
Severe fever with thrombocytopenia syndrome (SFTS) is a hemorrhagic fever caused by SFTS virus (SFTSV), which is primarily found in East Asian...
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Development of Immunoliposomes Using Monoclonal Antibodies Targeting Cancer Stem Cells
A cell surface glycoprotein of hyaluronic acid (HA) receptor is known as CD44, which is often overexpressed in most types of tumors. CD44 has...
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Cross-Reactive Polyclonal Antibodies Raised Against GalNAc-Conjugated siRNA Recognize Mostly the GalNAc Moiety
Small interfering RNA (siRNA) is gaining momentum as a therapeutic modality with six approved products. Since siRNA has the potential to elicit...
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In vivo affinity maturation of mouse B cells reprogrammed to express human antibodies
Mice adoptively transferred with mouse B cells edited via CRISPR to express human antibody variable chains could help evaluate candidate vaccines and...
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Preparation of monoclonal antibodies against Epstein-Barr virus glycoprotein 350
Epstein-Barr virus (EBV) is the first identified human oncogenic herpesvirus infecting over 90% of the adults worldwide. However, the safe and...
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Absolute quantitation of binding antibodies from clinical samples
The quantitation of antibody responses is a critical requirement for the successful development of vaccines and therapeutics that often relies on the...
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Anti-calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Clinical Pharmacokinetics
The calcitonin gene-related peptide transmission was the target for recent development of drugs that effectively prevent attacks of both episodic and...