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Novel benzenesulfonamide bearing 1,2,4-triazoles as potent anti-microbial and anti-oxidant agents
A series comprising 30 novel benzenesulfonamide bearing 1,2,4-triazoles 1a – 1h , 2a – 2h , 3a – 3h , 4b – 4f and 4h has been synthesized and investigated as...
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The Role of Epigenetics in the Development of Anti-Tuberculosis Drug Resistance
Mycobacterium tuberculosisMycobacterium tuberculosis (M. tb) is an airborne infectious agent that causes tuberculosis (TB). The Bacillus...
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Chronic hyperglycemia impairs anti-microbial function of macrophages in response to Mycobacterium tuberculosis infection
Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB), though the underlying mechanisms linking DM and TB remain ambiguous. Macrophages...
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Pharmacotherapy of Microbial Diseases
Microbial diseases comprise a significant portion of the global disease burden. Starting from moderate flulike condition to serious life-threatening...
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Microbial Infections
The host-parasite relationship is determined by the interaction between host factors and the infecting microorganisms. The outcome of any microbial...
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Defense and anti-defense mechanisms of bacteria and bacteriophages
In the post-antibiotic era, the overuse of antimicrobials has led to a massive increase in antimicrobial resistance, leaving medical doctors few or...
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Microbial regulation of intestinal motility provides resistance against helminth infection
Soil-transmitted helminths cause widespread disease, infecting ~1.5 billion people living within poverty-stricken regions of tropical and subtropical...
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Redefining bioactive small molecules from microbial metabolites as revolutionary anticancer agents
Cancer treatment remains a significant challenge due to issues such as acquired resistance to conventional therapies and the occurrence of adverse...
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A Comprehensive Pilot Study to Elucidate the Distinct Gut Microbial Composition and Its Functional Significance in Cardio-Metabolic Disease
Cardio-metabolic disease is a significant global health challenge with increasing prevalence. Recent research underscores the disruption of gut...
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Carbon Nanomaterials as Antimicrobial Agents to Combat Multidrug Resistance
Microorganisms have developed resistance to common antimicrobial medications because of incorrect and excessive usage, demanding innovative...
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Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution
In the beginning it was simple: we injected a protein antigen and studied the immune responses against the purified protein. This elegant toolbox...
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Nanotechnology-Based Tools to Overcome Antimicrobial Resistance
The World Health Organisation (WHO) has called for the rapid development of effective technology to tackle antimicrobial resistance (AMR). Poor...
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Microbial Nanotechnology in Treating Multidrug-Resistance Pathogens
Multidrug-resistant organisms (MDROs) such as viruses, bacteria, fungi, and parasites have caused significant mortalities worldwide. The continuous...
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Gut Microbes: Role in Cancer and Cancer Drug Resistance
The gut microbiota is becoming more and more of a research area in many diseases, including cancer, obesity, diabetes, brain disease, rheumatoid...
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Phytonanotechnologies for Addressing Antimicrobial Resistance
Antibiotic resistance has become a major issue, resulting in hundreds of thousands of deaths each year. This necessitates the use of more toxic,...
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Natural Product-Based Anti-Viral Agents Against RNA Viruses: An Important Strategy for Pandemic Preparedness
Anthropogenic factors and climate changes result in the emergence and re-emergence of infectious diseases. Viruses are one of the major causative...
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Introduction to Breast Cancer and Drug Resistance
Breast cancer is the most prevalent cancer in women, worldwide. Thus, it has attained the number one spot as the most diagnosed cancer in most...
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Gut microbial metabolites SCFAs and chronic kidney disease
The global incidence of Chronic Kidney Disease (CKD) is steadily escalating, with discernible linkage to the intricate terrain of intestinal...
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Antibiofilm activity of marine microbial natural products: potential peptide- and polyketide-derived molecules from marine microbes toward targeting biofilm-forming pathogens
Controlling and treating biofilm-related infections is challenging because of the widespread presence of multidrug-resistant microbes. Biofilm, a...
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Nanocomposites in Combating Antimicrobial Resistance
Extensive and improper usage of antibiotics has resulted in the outbreak of multidrug-resistant microorganisms and increasing antimicrobial...