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Molecular Profiling of VGluT1 AND VGluT2 Ventral Subiculum to Nucleus Accumbens Shell Projections
The nucleus accumbens shell is a critical node in reward circuitry, encoding environments associated with reward. Long-range inputs from the ventral...
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Anatomical analyses of collateral prefrontal cortex projections to the basolateral amygdala and the nucleus accumbens core in rats
The basolateral amygdala (BLA) and the nucleus accumbens core (NAcc) share some similar behavioral functions, such as associative learning, Pavlovian...
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Serotonin and Dopamine Show Different Response Profiles to Acute Stress in the Nucleus Accumbens and Medial Prefrontal Cortex of Rats with Neuropathic Pain
The ability to adaptively guide behaviour requires the integration of external information with internal motivational factors. Decision-making...
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Nucleus accumbens ghrelin signaling controls anxiety-like behavioral response to acute stress
BackgroundAnxiety disorders are one of the most common mental disorders. Ghrelin is a critical orexigenic brain-gut peptide that regulates food...
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Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell
BackgroundThe nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cortex (ILC) to the...
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Three-Dimensional Spatial Analyses of Cholinergic Neuronal Distributions Across The Mouse Septum, Nucleus Basalis, Globus Pallidus, Nucleus Accumbens, and Caudate-Putamen
Neuronal networks are regulated by three-dimensional spatial and structural properties. Despite robust evidence of functional implications in the...
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Prokineticin-2 Participates in Chronic Constriction Injury-Triggered Neuropathic Pain and Anxiety via Regulated by NF-κB in Nucleus Accumbens Shell in Rats
Neuropathic pain (NP) is an intractable pain that results from primary nervous system injury and dysfunction. Herein, we demonstrated in animal...
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Retinoic acid-mediated homeostatic plasticity in the nucleus accumbens core contributes to incubation of cocaine craving
RationaleIncubation of cocaine craving refers to the progressive intensification of cue-induced craving during abstinence from cocaine...
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Proteome profile of nucleus accumbens (NAc) uncovers the differential and sex-specific role of CRMP2 in CVMS-induced mouse model of depression
Chronic stress plays a very important role in building pathogenesis of psychiatric disorders including major depressive disorder (MDD). Despite of...
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Modulation of Nicotine-Associated Behaviour in Rats By μ-Opioid Signals from the Medial Prefrontal Cortex to the Nucleus Accumbens Shell
Nicotine addiction is a concern worldwide. Most mechanistic investigations are on nicotine substance dependence properties based on its...
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Dopamine signaling in the nucleus accumbens core mediates latent inhibition
Studies investigating the neural mechanisms by which associations between cues and predicted outcomes control behavior often use associative learning...
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Region-specific activation in the accumbens nucleus by itch with modified scratch efficacy in mice – a model-free multivariate analysis
Itch is a protective/defensive function with divalent motivational drives. Itch itself elicits an unpleasant experience, which triggers the urge to...
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Sex differences in membrane properties and cellular excitability of dopamine D1 receptor-expressing neurons within the shell of the nucleus accumbens of pre- and mid-adolescent mice
BackgroundThe transition from childhood to adulthood, or adolescence, a developmental stage, is characterized by psychosocial and biological changes....
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Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating
Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder...
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Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex
BackgroundThe development and persistence of addiction is mediated in part by drug-induced alterations in nucleus accumbens (NAc) function. AMPA-type...
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Nucleus accumbens core dopamine D2 receptors are required for performance of the odor span task in male rats
RationaleThe nucleus accumbens (NAc) core gates motivationally relevant behavioral action sequences through afferents from cortical and subcortical...
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Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder
Social behavior emerges early in development, a time marked by the onset of neurodevelopmental disorders featuring social deficits, including autism...
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Decoding molecular and cellular heterogeneity of mouse nucleus accumbens
The nucleus accumbens (NAc) plays an important role in regulating multiple behaviors, and its dysfunction has been linked to many neural disorders....
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Modeling nucleus accumbens
Nucleus accumbens is part of the neural structures required for reward based learning and cognitive processing of motivation. Understanding its...
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The Nucleus Accumbens CRH–CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse
Adverse experiences in early life have long-lasting negative impacts on behavior and the brain in adulthood, one of which is sleep disturbance. As...
