Search
Search Results
-
Extracellular vesicles released by glioma cells are decorated by Annexin A2 allowing for cellular uptake via heparan sulfate
Extracellular vesicles (EVs) play a crucial role in regulating cell behavior by delivering their cargo to target cells. However, the mechanisms...
-
Human colorectal cancer-associated carbohydrate antigen on annexin A2 protein
AbstractCancer-associated antigens are not only a good marker for monitoring cancer progression but are also useful for molecular target therapy. In...
-
Bufalin induces mitochondrial dysfunction and promotes apoptosis of glioma cells by regulating Annexin A2 and DRP1 protein expression
BackgroundGlioma is a common primary central nervous system tumour, and therapeutic drugs that can effectively improve the survival rate of patients...
-
Recombinant annexin A2 inhibits peripheral leukocyte activation and brain infiltration after traumatic brain injury
BackgroundTraumatic brain injury (TBI) is a significant cause of death and disability worldwide. The TLR4-NFκB signaling cascade is the critical...
-
MicroRNA-425-5p modulates osteoporosis by targeting annexin A2
BackgroundStudies have shown that the decrease of osteogenic differentiation of bone marrow mesenchymal stem cells (MSC) is an important mechanism of...
-
Molecular analysis of Annexin expression in cancer
BackgroundUptake of apoptotic cells induces a tolerogenic phenotype in phagocytes and promotes peripheral tolerance. The highly conserved Annexin...
-
Lack of Annexin A1 Exacerbates Inflammatory Response in Acute Endometritis Model
Annexin A1 (AnxA1) is a glucocorticoid-inducible protein and an important endogenous modulator of inflammation. However, its effect in the...
-
Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies
BackgroundAcute gouty arthritis is inflammatory joint arthritis. Gouty arthritis (GA) involves multiple pathological processes. Deposition of joints...
-
Silencing AHNAK promotes nasopharyngeal carcinoma progression by upregulating the ANXA2 protein
PurposeNasopharyngeal carcinoma (NPC) is an aggressive head and neck disease with a high incidence of distant metastases. Enlargeosomes are...
-
Identification of human MHC-I HPV18 E6/E7-specific CD8 + T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice
BackgroundHuman Papillomavirus type 18 (HPV18) is a high-risk HPV that is commonly associated with cervical cancer. HPV18 oncogenes E6 and E7 are...
-
Angiostrongylus cantonensis Galectin-1 interacts with Annexin A2 to impair the viability of macrophages via activating JNK pathway
BackgroundAngiostrongylus cantonensis can cause severe symptoms of central nervous system infections. In the host, this parasite localizes in the...
-
Selective imaging of solid tumours via the calcium-dependent high-affinity binding of a cyclic octapeptide to phosphorylated Annexin A2
The heterogeneity and continuous genetic adaptation of tumours complicate their detection and treatment via the targeting of genetic mutations....
-
Annexin A2–STAT3–Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma
Glioblastoma (GBM) is characterized by extensive tumor cell invasion, angiogenesis, and proliferation. We previously established subclones of GBM...
-
Serum exosomal-annexin A2 is associated with African-American triple-negative breast cancer and promotes angiogenesis
BackgroundLimited information is available on biomarker(s) for triple-negative breast cancer (TNBC) that can address the higher incidence and...
-
Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells
In Alzheimer disease (AD), Tau, an axonal microtubule-associated protein, becomes hyperphosphorylated, detaches from microtubules, accumulates, and...
-
Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischemic Attack in Mice
A transient ischemic attack (TIA) can cause reversible and delayed impairment of cognition, but the specific mechanisms are still unclear. Annexin a1...
-
The antitumor effect of oncolytic respiratory syncytial virus via the tumor necrosis factor-alpha induction and ROS-bax-mediated mechanisms
BackgroundCervical cancer represents one of the most prevalent cancers among women worldwide, particularly in low- and middle-income nations....
-
Dissecting the MUC5AC/ANXA2 signaling axis: implications for brain metastasis in lung adenocarcinoma
Non-small cell lung carcinoma (NSCLC) exhibits a heightened propensity for brain metastasis, posing a significant clinical challenge. Mucin 5ac...
-
Electrical Stimulation of the Auricular Branch Vagus Nerve Using Random and Alternating Frequencies Triggers a Rapid Onset and Pronounced Antihyperalgesia via Peripheral Annexin A1-Formyl Peptide Receptor 2/ALX Pathway in a Mouse Model of Persistent Inflammatory Pain
This study evaluated the antihyperalgesic and anti-inflammatory effects of percutaneous vagus nerve electrical stimulation (pVNS) by comparing the...
-
Promoter Hypomethylation Upregulates ANXA2 Expression in Pancreatic Cancer and is Associated with Poor Prognosis
Pancreatic cancer (PC) is one of the world’s most aggressive and deadly cancers, owing to non-specific early clinical symptoms, late-stage diagnosis,...
