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Animal Welfare Aspects in Planning and Conducting Experiments on Rodent Models of Subarachnoid Hemorrhage
Subarachnoid hemorrhage is an acute life-threatening cerebrovascular disease with high socio-economic impact. The most frequent cause, the rupture of...
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Insomnia-related rodent models in drug discovery
Despite the widespread prevalence and important medical impact of insomnia, effective agents with few side effects are lacking in clinics. This is...
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Diabetic Rodent Models for Chronic Stroke Studies
Chronic diabetes may cause secondary complications like stroke and also increase post-stroke brain damage. In stroke research, the Stroke Therapy...
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Lysosomal Pathogenesis of Parkinson’s Disease: Insights From LRRK2 and GBA1 Rodent Models
The discovery of mutations in LRRK2 and GBA1 that are linked to Parkinson’s disease provided further evidence that autophagy and lysosome pathways...
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Rodent Stroke Models to Study Functional Recovery and Neural Repair
Rodent ischemic stroke models are essential research tools for studying this highly prevalent disease and represent a critical element in the...
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Transient Receptor Potential Channels: Multiple Modulators of Peripheral Neuropathic Pain in Several Rodent Models
Neuropathic pain, a prevalent chronic condition in clinical settings, has attracted widespread societal attention. This condition is characterized by...
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Auditory processing in rodent models of autism: a systematic review
Autism is a complex condition with many traits, including differences in auditory sensitivity. Studies in human autism are plagued by the difficulty...
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Protective Effect of Ergothioneine Against Stroke in Rodent Models
Ergothioneine (ET) is a naturally occurring antioxidant and cytoprotective agent that is synthesized by fungi and certain bacteria. Recent studies...
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Retinal Assessment Using In Vivo Electroretinography and Optical Coherence Tomography in Rodent Models of Diabetes
Electroretinography and optical coherence tomography imaging allow for non-invasive quantitative assessment of the retina. These approaches have...
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Critical Evaluation of Valproic Acid-Induced Rodent Models of Autism: Current and Future Perspectives
Valproic acid (VPA) induced rodent model of autism is a widely accepted and extensively used rodent model to investigate the pharmacotherapy against...
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A Pilot Systematic Review and Meta-analysis of Neuroprotective Studies in Female Rodent Models of Ischemic Stroke
Most ischemic stroke (IS) patients go untreated due to limited treatment windows, restrictive eligibility criteria, and poor availability of current...
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DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway
Dry eye disease (DED) is a prevalent ocular disorder with a multifactorial etiology. The pre-angiogenic and pre-inflammatory milieu of the ocular...
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VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson’s disease
BackgroundMutations in the vacuolar protein sorting 35 ortholog ( VPS35 ) gene cause late-onset, autosomal dominant Parkinson’s disease (PD), with a...
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Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges
In order to dissect amyotrophic lateral sclerosis (ALS), a multigenic, multifactorial, and progressive neurodegenerative disease with heterogeneous...
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Accumulation of Prion Triggers the Enhanced Glycolysis via Activation of AMKP Pathway in Prion-Infected Rodent and Cell Models
Mitochondrial dysfunction is one of the hallmarks in the pathophysiology of prion disease and other neurodegenerative diseases. Various metabolic...
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In Vivo Imaging of Nipah Virus Infection in Small Animal Rodent Models
In vivo imaging system (IVIS) is a powerful tool for the study of infectious diseases, providing the ability to non-invasively follow viral infection...
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Rodent Models of Spinal Cord Injury: From Pathology to Application
Spinal cord injury (SCI) often has devastating consequences for the patient's physical, mental and occupational health. At present, there is no...
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Cerebrospinal fluid shotgun proteomics identifies distinct proteomic patterns in cerebral amyloid angiopathy rodent models and human patients
Cerebral amyloid angiopathy (CAA) is a form of small vessel disease characterised by the progressive deposition of amyloid β protein in the cerebral...
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Consequences of nano and microplastic exposure in rodent models: the known and unknown
The ubiquitous nature of micro- (MP) and nanoplastics (NP) is a growing environmental concern. However, their potential impact on human health...
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The effects of melatonin supplementation on neurobehavioral outcomes and clinical severity in rodent models of multiple sclerosis; a systematic review and meta-analysis
BackgroundThrough the antioxidant and anti-inflammation pathways, melatonin is proposed as a safe and effective intervention in neurological...
