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Lectures 9 and 10: Endocrine System & Hormones
The Endocrine System consists the following organs: Hypothalamus, pituitary (anterior & posterior parts), pineal, thyroid, 4 parathyroids, thymus,...
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A Ying-Yang Perspective on the Renin Angiotensin System in Cardiovascular Disease
The renin angiotensin systemRenin angiotensin system (RAS) plays a critical role in the regulation of the homeostatic control of arterial pressure,...
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The effect of tannic acid on renal renin-angiotensin signaling pathway in a model of unilateral ureteral obstruction in male Wistar rats
The purpose of current study was to elucidate polyphenol tannic acid effect on renal function and activity of the renin-angiotensin system after...
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Role of Renin Angiotensin-Aldosterone System in Kidney Homeostasis
The Renin-Angiotensin-Aldosterone System (RAAS), which regulates plasma sodium levels, arterial blood pressure, and extracellular volume, is a...
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Genetic Polymorphisms in the Renin-Angiotensin-Aldosterone System
This chapter presents the evaluation of the impact of nonsynonymous single nucleotide polymorphisms (nsSNPs) in the renin-angiotensin-aldosterone...
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Correlation Between Renin Angiotensin System and Infectious Disease
The renin- angiotensin system (RAS) is a physiological system that through a cascade of mediators and different mechanisms is able to regulate...
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A niche-mimicking polymer hydrogel-based approach to identify molecular targets for tackling human pancreatic cancer stem cells
BackgroundPancreatic adenocarcinoma (PAAD) is one of the most fatal human cancers, but effective therapies remain to be established. Cancer stem...
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Serum Angiotensin II as a Biomarker in COVID-19
Angiotensin II, synthesized by the cleavage of angiotensinogen to angiotensin I by renin and then conversion to angiotensin II by the...
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Renal angiotensin I-converting enzyme-deficient mice are protected against aristolochic acid nephropathy
The renal renin-angiotensin system (RAS) is involved in the development of chronic kidney disease. Here, we investigated whether mice with reduced...
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The tobacco-specific carcinogen NNK induces pulmonary tumorigenesis via nAChR/Src/STAT3-mediated activation of the renin-angiotensin system and IGF-1R signaling
The renin-angiotensin (RA) system has been implicated in lung tumorigenesis without detailed mechanistic elucidation. Here, we demonstrate that...
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Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis
BackgroundMultiple sclerosis is an inflammatory and degenerative disease of the central nervous system (CNS) characterized by demyelination and...
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Serum Angiotensin II as a Biomarker in COVID-19
Angiotensin II, synthesized by the cleavage of angiotensinogen to angiotensin I by renin and then conversion to angiotensin II by the...
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Renin-Angiotensin System in Hematological Malignancies
The regular functioning of the human body is the result of interactions between numerous organs and biological systems, with the Renin-Angiotensin...
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Implications of Renin-Angiotensin System in Health and Disease
The renin-angiotensin system (RAS) is one of major neuro-endocrine entity which is intimately involved in regulating the cellular functions and...
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The role of the brain renin-angiotensin system in Parkinson´s disease
The renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues...
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The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental roles in cancer biology which influences cell growth,...
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The Classical and Nonclassical Renin-Angiotensin-Aldosterone System in Liver Cirrhosis
In chronic liver disease, excess hepatic deposition of extracellular matrix, the ensuing development of cirrhosis, the associated renal dysfunction,...
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A Comprehensive Review of the Impact of the Renin Angiotensin System in the Liver, Lung, Infectious Diseases and Cancers
Renin angiotensin aldosterone system has long been known for its role in the regulation of blood pressure and hydro-electrolyte balance in human...