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Biomedicine

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Showing 1-20 of 26 results

  1. Relevance of iNOS expression in tumor growth and maintenance of cancer stem cells in a bladder cancer model

    Abstract

    The expression of inducible nitric oxide (NO) synthase (iNOS) in human bladder cancer (BC) is a poor prognostic factor associated with...

    Denise Belgorosky, Julie Girouard, ... Ana María Eiján in Journal of Molecular Medicine
    Article 16 September 2020

  2. EGFR modulates complement activation in head and neck squamous cell carcinoma

    Background

    The epidermal growth factor receptor (EGFR) is pivotal for growth of epithelial cells and is overexpressed in several epithelial cancers...

    Anas H. A. Abu-Humaidan, Lars Ekblad, ... Ole E. Sørensen in BMC Cancer
    Article Open access 13 February 2020

  3. Anticancer activity of Astragalus polysaccharide in human non-small cell lung cancer cells

    Background

    We have reported that Chinese herbs Astragalus polysaccharide (APS) can inhibit nuclear factor kappaB (NF-κB) activity during the...

    Chao-Yan Wu, Yuan Ke, ... Hai-Jun Yu in Cancer Cell International
    Article Open access 04 December 2017

  4. Anti-VEGFR2 and anti-IGF-1R-Adnectins inhibit Ewing’s sarcoma A673-xenograft growth and normalize tumor vascular architecture

    Increasing experimental evidence suggests that IGF-1 may modulate tumor angiogenesis via activation of the expression of VEGF in Ewing sarcomas and...

    Maximilian Ackermann, Brent A. Morse, ... Moritz A. Konerding in Angiogenesis
    Article 23 August 2012

  5. Reverse Phase Protein Microarrays and Their Utility in Drug Development

    The majority of human diseases, including cancer, are characterized by abnormal protein function. Proteins regulate virtually every cellular process...
    Maria Isabella Sereni, Mariaelena Pierobon, ... Mitchell J. Frederick in Target Identification and Validation in Drug Discovery
    Protocol 2013

  8. The role of cellular oxidative stress in regulating glycolysis energy metabolism in hepatoma cells

    Background

    The Warburg effect has been found in a wide spectrum of human cancers, however the underlying mechanisms are still unclear. This study aims...

    Dong-yun Shi, Fei-zhou **e, ... Shan-lin Liu in Molecular Cancer
    Article Open access 05 June 2009

  9. Molecular targeted therapies for breast cancer treatment

    Targeting the oestrogen receptor, HER2 (human epidermal growth factor receptor 2) and vascular endothelial growth factor has markedly improved breast...

    Claus M Schlotter, Ulf Vogt, ... Burkhard Brandt in Breast Cancer Research
    Article 24 July 2008

  10. The Hu/Mu ProtIn Chip: A Custom Dual-Species Oligonucleotide Microarray for Profiling Degradome Gene Expression in Tumors and Their Microenvironment

    Proteases and protease inhibitors of the cancer degradome derive from tumor-associated cells as well as tumor cells. Xenograft studies in which human...
    Donald R. Schwartz, Kamiar Moin, ... Bonnie F. Sloane in The Cancer Degradome
    Chapter 2008

  11. The Biology of Bone Metastases from Prostate Cancer and the Role of Bisphosphonates

    Bone metastases from prostate cancer are a associated with morbidity and death from the disease. Prostate cancer cells are found in the circulation...
    Noel W. Clarke, Herbert A. Fleisch in Metastasis of Prostate Cancer
    Chapter 2008

  12. Abnormal variation of the immune response as related to cancer

    This overview chapter reviews the complex interrelationship between the immune system, cell proliferation and cancer. There exist, in essence, two...
    Gerhard R. F. Krueger, L. Maximilian Buja in Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response
    Chapter 2008

  13. PHARMACOKINETICS AND PHARMACODYNAMICS OF CURCUMIN

    Curcuma spp. contain turmerin, essential oils, and curcuminoids, including curcumin. Curcumin...
    Ricky A. Sharma, William P. Steward, Andreas J. Gescher in The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
    Chapter 2007

  15. Evolving concepts in the pathogenesis of hairy-cell leukaemia

    Hairy-cell leukaemia (HCL) has long been recognized as distinct from other chronic B-cell malignancies, but several questions remain unanswered. What...

    Enrico Tiacci, Arcangelo Liso, ... Brunangelo Falini in Nature Reviews Cancer
    Article 01 June 2006

  16. T-cell cytokines in injury-induced neural damage and repair

    T-cell cytokines are involved in beneficial immune responses, pathological autoimmunity, and tissue inflammation. In this review, we focus on the...

    Michael Schroeter, Sebastian Jander in NeuroMolecular Medicine
    Article 01 August 2005

  18. c-Met: Structure, functions and potential for therapeutic inhibition

    Studies on signal transduction pathways have generated various promising molecular targets for therapeutic inhibition in cancer therapy. Receptor...

    Patrick C. Ma, Gautam Maulik, ... Ravi Salgia in Cancer and Metastasis Reviews
    Article 01 December 2003

  19. The role of proteinases in joint tissue destruction

    The breakdown of cartilage and bone in the arthritides prevents joints from functioning normally. In severe cases both cartilage and the underlying...
    Tim E. Cawston, Andrew D. Rowan in Cytokines and Joint Injury
    Chapter 2004

  20. Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors

    In addition to housekee** cyclooxygenase (COX)-1, which is constitutively expressed in many body cells, an inducible COX-2 has been described and...

    M. Katori, M. Majima in Inflammation Research
    Article 01 August 2000
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