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Aneuploidy is Linked to Neurological Phenotypes Through Oxidative Stress
Aneuploidy, having an aberrant genome, is gaining increasing attention in neurodegenerative diseases. It gives rise to proteotoxic stress as well as...
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Aneuploidy during development in facultative parthenogenetic Drosophila
From concatenated chromosomes to polyploidization, large-scale genome changes are known to occur in parthenogenetic animals. Here, we report mosaic...
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Tumor aneuploidy predicts survival following immunotherapy across multiple cancers
Tumor mutational burden (TMB) has emerged as a promising biomarker of immunotherapy response across multiple cancer types; however, clinical outcomes...
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Prenatal diagnosis of mosaic chromosomal aneuploidy and uniparental disomy and clinical outcomes evaluation of four fetuses
BackgroundFew co-occurrence cases of mosaic aneuploidy and uniparental disomy (UPD) chromosomes have been reported in prenatal periods. It is a big...
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Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns
Whole chromosome and arm-level copy number alterations occur at high frequencies in tumors, but their selective advantages, if any, are poorly...
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Growth hormone reduces aneuploidy and improves oocytes quality by JAK2-MAPK3/1 pathway in aged mice
BackgroundThe global delay in women’s reproductive age has raised concerns about age-related infertility. The decline in oocyte quality is a limiting...
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FISHing for Chromosome Instability and Aneuploidy in the Alzheimer’s Disease Brain
Fluorescence in situ hybridization (FISH) is the method of choice for visualizing chromosomal DNA in post-mitotic cells. The availability of...
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Predicting embryonic aneuploidy rate in IVF patients using whole-exome sequencing
Infertility is a major reproductive health issue that affects about 12% of women of reproductive age in the United States. Aneuploidy in eggs...
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Integrative analyses of maternal plasma cell-free DNA nucleosome footprint differences reveal chromosomal aneuploidy fetuses gene expression profile
BackgroundChromosomal aneuploidy is the most common birth defect. However, the developmental mechanism and gene expression profile of fetuses with...
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Preimplantation genetic testing for aneuploidy: challenges in clinical practice
Preimplantation genetic testing for aneuploidy (PGT-A) has been used widely during in vitro fertilization procedures in assisted reproductive centers...
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Double aneuploidy mosaicism involving chromosomes 18 and 21 in a neonate
BackgroundDouble aneuploidy is common, especially in products of conception, frequently involving a combination of a sex chromosome and an...
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Exploring the efficacy and beneficial population of preimplantation genetic testing for aneuploidy start from the oocyte retrieval cycle: a real-world study
BackgroundPreimplantation genetic testing for aneuploidy (PGT-A) is widely used as an embryo selection technique in in vitro fertilization (IVF), but...
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A fetal fraction enrichment method reduces false negatives and increases test success rate of fetal chromosome aneuploidy detection in early pregnancy loss
ObjectiveWe and others have previously demonstrated that the size-selection enrichment method could remarkably improve fetal fraction (FF) in the...
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Haploty**-based preimplantation genetic testing reveals parent-of-origin specific mechanisms of aneuploidy formation
Chromosome instability is inherent to human IVF embryos, but the full spectrum and developmental fate of chromosome anomalies remain uncharacterized....
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Identification of aneuploidy in dogs screened by a SNP microarray
Microarray analysis is an efficient approach for screening and identifying cytogenetic imbalances in humans. SNP arrays, in particular, are a...
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Chromosome aneuploidy analysis in embryos derived from in vivo and in vitro matured human oocytes
BackgroundIn vitro oocyte maturation (IVM) is being increasingly approached in assisted reproductive technology (ART). This study aimed to evaluate...
