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Reduction of BRCA1 Induced by Sevoflurane Exacerbates the Neurotoxicity of Amyloid-β
AbstractInhaled anesthetic sevoflurane is widely reported to induce neurotoxicity, whereas the underlying mechanism is less elucidated. Here, we...
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GlyT1 Inhibition by NFPS Promotes Neuroprotection in Amyloid-β-Induced Alzheimer’s Disease Animal Model
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β, leading to N-methyl-D-aspartate (NMDA)...
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Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology
Aging is the main risk factor for Alzheimer’s disease (AD) and other neurodegenerative pathologies, but the molecular and cellular changes underlying...
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Fully automated and highly specific plasma β-amyloid immunoassays predict β-amyloid status defined by amyloid positron emission tomography with high accuracy
BackgroundClinicians, researchers, and patients alike would greatly benefit from more accessible and inexpensive biomarkers for neural β-amyloid...
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Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is a neurodegenerative condition often co-occurring with Alzheimer’s disease (AD) pathology. Characterizing white...
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Association between retinal microvascular abnormalities and late-life brain amyloid-β deposition: the ARIC-PET study
BackgroundRetinal microvascular signs are accessible measures of early alterations in microvascular dysregulation and have been associated with...
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Amyloid-β specific regulatory T cells attenuate Alzheimer’s disease pathobiology in APP/PS1 mice
BackgroundRegulatory T cells (Tregs) maintain immune tolerance. While Treg-mediated neuroprotective activities are now well-accepted, the lack of...
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Neuroprotective role of nobiletin against amyloid-β (Aβ) aggregation in Parkinson and Alzheimer disease as neurodegenerative diseases of brain
The presence of neuronal amyloid β (Aβ) plaques and neurofibrillary tangles are the main indicators of Alzheimer’s disease (AD) and Parkinson’s...
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Amyloid β oligomer induces cerebral vasculopathy via pericyte-mediated endothelial dysfunction
BackgroundAlthough abnormal accumulation of amyloid beta (Aβ) protein is thought to be the main cause of Alzheimer’s disease (AD), emerging evidence...
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β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice
Extensive studies indicate that β-amyloid (Aβ) aggregation is pivotal for Alzheimer’s disease (AD) progression; however, cumulative evidence suggests...
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Continuity of care (COC) and amyloid-β PET scan: the CARE-IDEAS study
BackgroundHigh continuity of care (COC) is associated with better clinical outcomes among older adults. The impact of amyloid-β PET scan on COC among...
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Amyloid-β in Brain Aging and Alzheimer’s Disease
During aging, the brain milieu changes in a multitude of ways, resulting in a decline of physiological functions and increased susceptibility to...
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The Role of JNK and p53 in the Regulation of Secretory Function of Neuroglial Cells of Various Types in β-Amyloid-Induced Neurodegeneration
We studied the effect of JNK and p53 inhibitors on the production of neurotrophic factors stimulating the realization of the growth potential of...
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Predicting conversion of brain β-amyloid positivity in amyloid-negative individuals
BackgroundCortical deposition of β-amyloid (Aβ) plaque is one of the main hallmarks of Alzheimer’s disease (AD). While Aβ positivity has been the...
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Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice
Non-invasive methods for the in vivo detection of hallmarks of Alzheimer’s disease can facilitate the study of the progression of the disease in...
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Functional State of Various Types of Regenerative-Competent Neural Tissue Cells in β-Amyloid-Induced Neurodegeneration
We analyzed the content and functional activity of various types of regenerative-competent cells of the subventricular zone of the cerebral...
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Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease
Natural antibodies (nAbs) against aggregation-prone proteins have been found in healthy normal subjects. These proteins likely have a pathogenetic...
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Sex-Specific Entorhinal Cortex Functional Connectivity in Cognitively Normal Older Adults with Amyloid-β Pathology
Sex and apolipoprotein E (APOE) genotype have been shown to influence the risk and progression of Alzheimer’s disease (AD). However, the impact of...
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Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice
BackgroundAmyloid-related imaging abnormalities (ARIA) have been identified as the most common and serious adverse events resulting from pathological...
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Effect of disturbances in neuronal calcium and IP3 dynamics on β-amyloid production and degradation
Overproduction and accumulation of β-amyloid and its improper clearance can cause neurotoxicity leading to Alzheimer’s disease. The production and...
