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Antifungal activity of aminoalcohols and diamines against dermatophytes and yeast
Dermatomycoses are infections caused by fungi and yeasts and the drug treatment is considered expensive and extensive. Researchers are synthesizing...
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Benzimidazole and aminoalcohol derivatives show in vitro anthelmintic activity against Trichuris muris and Heligmosomoides polygyrus
BackgroundInfections by gastrointestinal nematodes cause significant economic losses and disease in both humans and animals worldwide. The discovery...
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A new protocol for whole-brain biodistribution analysis of AAVs by tissue clearing, light-sheet microscopy and semi-automated spatial quantification
Recombinant adeno-associated virus (rAAV) has become one of the most promising gene delivery systems for both in vitro and in vivo applications....
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Carbonic Anhydrase Inhibitors: Identifying Therapeutic Cancer Agents Through Virtual Screening
Computer-aided drug designComputer-aided drug design includes an ensemble of different in silico strategies that represent valuable tools for...
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Advanced Immunolabeling Method for Optical Volumetric Imaging Reveals Dystrophic Neurites of Dopaminergic Neurons in Alzheimer’s Disease Mouse Brain
Optical brain clearing combined with immunolabeling is valuable for analyzing molecular tissue structures, including complex synaptic connectivity....
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Recent Development on Sensing Strategies for Small Molecules Detections
Sensors play a critical role in the detection and monitoring of various substances present in our environment, providing us with valuable information...
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Alsinol, an arylamino alcohol derivative active against Plasmodium, Babesia, Trypanosoma, and Leishmania: past and new outcomes
Malaria, babesiosis, trypanosomosis, and leishmaniasis are some of the most life-threatening parasites, but the range of drugs to treat them is...
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Design, synthesis, and antitumor evaluation of novel anthraquinone derivatives
N -alkylated and O -alkylated anthraquinone derivatives with structures analogous to mitoxantrone were synthesized, characterized, and evaluated for...
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Site-Specific Modification of Nucleobases in Oligonucleotides
Site-specific modification of oligonucleotides is a powerful approach for synthesis of oligonucleotides containing various derivatives of...
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In vitro and in vivo evaluation of 2-aminoalkanol and 1,2-alkanediamine derivatives against Strongyloides venezuelensis
BackgroundStrongyloidiasis is a parasitic disease widely present in tropical and subtropical areas. Strongyloides stercoralis represents the main...
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Chemical probes and drug leads from advances in synthetic planning and methodology
Screening of small-molecule libraries is a productive method for identifying both chemical probes of disease-related targets and potential starting...
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Imaging the mammary gland and mammary tumours in 3D: optical tissue clearing and immunofluorescence methods
BackgroundHigh-resolution 3D imaging of intact tissue facilitates cellular and subcellular analyses of complex structures within their native...
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Lipid glycosylation: a primer for histochemists and cell biologists
Glycolipids are glycoconjugates that are predominantly found on the extracellular surface of cells ranging from bacteria to men. In bacteria and...
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Form Meets Function in the Brain: Observing the Activity and Structure of Specific Neural Connections
Recent advances in neuroscience have enabled increasingly detailed insight into the activity and structure of brain circuitry. In previous work, we...
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Sleep as a biological problem: an overview of frontiers in sleep research
Sleep is a physiological process not only for the rest of the body but also for several brain functions such as mood, memory, and consciousness....
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Synthesis and cytotoxic activity of dibutyltin complexes derived from pyridoxamine and salicylaldehydes
The synthesis of monomeric pentacoordinated diorganotin complexes derived from pyridoxamine dihydrochloride and substituted salicylaldehydes is...
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Oxazolidin-2-Ones: Antibacterial Activity and Chemistry
Since the introduction in the pharmaceutical market of linezolid, an oxazolidin-2-one based new class of antibacterial agents with a unique mechanism...
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Lipid metabolism in Alzheimer’s disease
Lipids play crucial roles in cell signaling and various physiological processes, especially in the brain. Impaired lipid metabolism in the brain has...