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Systemic perturbations in amino acids/amino acid derivatives and tryptophan pathway metabolites associated with murine influenza A virus infection
BackgroundInfluenza A virus (IAV) is the only influenza virus causing flu pandemics (i.e., global epidemics of flu disease). Influenza (the flu) is a...
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Profiling the metabolic disorder and detection of colorectal cancer based on targeted amino acids metabolomics
BackgroundThe morbidity of cancer keeps growing worldwide, and among that, the colorectal cancer (CRC) has jumped to third. Existing early screening...
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Amino acids and risk of colon adenocarcinoma: a Mendelian randomization study
BackgroundThe existence of amino acid metabolic reprogramming in tumor cells is well established. However, the potential correlation between blood...
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Enantioselective Fluorescence Recognition of Free α-Amino Acids by Ion-Type Ammonium Salt-Based Sensors
Optically pure amino acids have extensive applications in pharmaceuticals, pesticides, food, materials, and other fields. Enantiomers recognition of...
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Altered Metabolome of Amino Acids Species: A Source of Signature Early Biomarkers of T2DM
Diabetes mellitus is a chronic metabolic disease with serious health consequences for a modern civilization that often lead to premature death. With...
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Effect of Noopept on the Content of Neurotransmitter Amino Acids in the Hippocampus in Alcoholized Rats Using In Vivo Microdialysis
Abstract — The aim of the present work was to study the dynamics of neurotransmitter amino acids after acute Noopept (a dipeptide analogue of piracetam...
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Amino Acids in Microbial Metabolism and Function
Amino acidsAmino acids (AAs) not only serve as building blocks for protein synthesis in microorganisms but also play important roles in their...
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Fluoride impairs vascular smooth muscle A7R5 cell lines via disrupting amino acids metabolism
Given the insidious and high-fatality nature of cardiovascular diseases (CVDs), the emergence of fluoride as a newly identified risk factor demands...
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Influence of Amino Acids on Autism and Attention-Deficit Hyperactive Disorder
Recent reports illustrated the increasing universal occurrence of autism and attention-deficit hyperactivity disorder (ADHD). Much of the...
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Preoperative profiles of plasma amino acids and derivatives distinguish periampullary cancer and benign disease
Periampullary cancers, including pancreatic ductal adenocarcinoma, ampullary-, cholangio-, and duodenal carcinoma, are frequently diagnosed in an...
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Anti-inflammatory peptide therapeutics and the role of sulphur containing amino acids (cysteine and methionine) in inflammation suppression: A review
BackgroundInflammation serves as our body’s immune response to combat infections, pathogens, viruses, and external stimuli. Inflammation can be...
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Amorphization of Low Soluble Drug with Amino Acids to Improve Its Therapeutic Efficacy: a State-of-Art-Review
Low aqueous solubility of drug candidates is an ongoing challenge and pharmaceutical manufacturers pay close attention to amorphization (AMORP)...
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The Effect of Pyridine Oxime Derivative (GIZh-298) and Sodium Valproate on the Neurotransmitter Amino Acids Content in the Brain Structures of Mice in the Maximal Electroshock Seizure Test
Abstract —Here we studied the effects of anti-epileptic substance GIZh-298 and the drug of comparison sodium valproate (NaV) on the contents of...
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Nucleic Acids: DNA and RNA
Nucleic acids are biomacromolecules that exist naturally in all the living organisms, and play fundamental roles in many biological processes such as...
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Dual contribution of the mTOR pathway and of the metabolism of amino acids in prostate cancer
BackgroundProstate cancer is the leading cause of cancer in men, and its incidence increases with age. Among other risk factors, pre-existing...
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Altered Metabolome of Amino Acids Species: A Source of Signature Early Biomarkers of T2DM
Diabetes mellitus is a chronic metabolic disease with serious health consequences for a modern civilization that often lead to premature death. With...
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Identification of Non-excitatory Amino Acids and Transporters Mediating the Irreversible Synaptic Silencing After Hypoxia
The contribution of excitatory amino acids (AA) to ischemic brain injury has been widely described. In addition, we reported that a mixture of...
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Causal relationships of circulating amino acids with cardiovascular disease: a trans-ancestry Mendelian randomization analysis
BackgroundEpidemiological studies demonstrated that multiple amino acids (AAs) were associated with cardiovascular diseases (CVDs), but whether these...
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Plasma metabolites of aromatic amino acids associate with clinical severity and gut microbiota of Parkinson’s disease
Gut microbial proteolytic metabolism has been reportedly altered in Parkinson’s disease (PD). However, the circulating aromatic amino acids (AAA)...
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Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease
Disturbances of circulating amino acids have been demonstrated in patients with Parkinson’s disease (PD). However, there have been no consistent...
