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Intersubject representational similarity analysis uncovers the impact of state anxiety on brain activation patterns in the human extrastriate cortex
The current study used functional magnetic resonance imaging (fMRI) and showed that state anxiety modulated extrastriate cortex activity in response...
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Alternative muscle synergy patterns of upper limb amputees
Myoelectric hand prostheses are effective tools for upper limb amputees to regain hand functions. Much progress has been made with pattern...
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CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity
Metabolic flexibility has emerged as a critical determinant of CD8+ T-cell antitumor activity, yet the mechanisms driving the metabolic flexibility...
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IL-37 alleviates liver granuloma caused by Schistosoma japonicum infection by inducing alternative macrophage activation
BackgroundHepatic macrophages regulate liver granuloma formation and fibrosis caused by infection with Schistosoma japonicum , with the manner of...
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The role of alternative pre-mRNA splicing in cancer progression
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the...
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The implications of alternative pre-mRNA splicing in cell signal transduction
Cells produce multiple mRNAs through alternative splicing, which ensures proteome diversity. Because most human genes undergo alternative splicing,...
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The KIR2DL1 intermediate upstream element participates in gene activation
The human KIR genes encode a family of class I MHC receptors that are expressed on subsets of NK cells. The expression of KIR proteins is controlled...
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A stepwise activation model for the insulin receptor
The binding of insulin to the insulin receptor (IR) triggers a cascade of receptor conformational changes and autophosphorylation, leading to the...
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EEG resting state alpha dynamics predict an individual’s vulnerability to auditory hallucinations
Task-free brain activity exhibits spontaneous fluctuations between functional states, characterized by synchronized activation patterns in...
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SIRT1 activation promotes energy homeostasis and reprograms liver cancer metabolism
BackgroundCancer cells are characterized by uncontrolled cell proliferation and impaired bioenergetics. Sirtuins are a family of highly conserved...
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PRMT2 silencing regulates macrophage polarization through activation of STAT1 or inhibition of STAT6
BackgroundMacrophages play significant roles in innate immune responses and are heterogeneous cells that can be polarized into M1 or M2 phenotypes....
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C–H Activation with Photoredox Catalysis
In recent years, the chemical community has become increasingly interested in novel modes of reactivity for the production of biologically relevant...
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Roles and mechanisms of aberrant alternative splicing in melanoma — implications for targeted therapy and immunotherapy resistance
BackgroundDespite advances in therapeutic strategies, resistance to immunotherapy and the off-target effects of targeted therapy have significantly...
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Disentanglement of Resting State Brain Networks for Localizing Epileptogenic Zone in Focal Epilepsy
The objective of this study is to extract pathological brain networks from interictal period of E/MEG recordings to localize epileptic foci for...
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Mutations in the alternative complement pathway in multiple myeloma patients with carfilzomib-induced thrombotic microangiopathy
Thrombotic microangiopathy (TMA) has been reported to occur in multiple myeloma (MM) patients in association with treatment with carfilzomib, an...
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Brain state and dynamic transition patterns of motor imagery revealed by the bayes hidden markov model
Motor imagery (MI) is a high-level cognitive process that has been widely applied to brain-computer inference (BCI) and motor recovery. In practical...
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Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease
Communication between glial cells has a profound impact on the pathophysiology of Alzheimer’s disease (AD). We reveal here that reactive astrocytes...
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New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation
AbstractInflammasomes are important modulators of inflammation. Dysregulation of inflammasomes can enhance vulnerability to conditions such as...
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Increased enhancer–promoter interactions during developmental enhancer activation in mammals
Remote enhancers are thought to interact with their target promoters via physical proximity, yet the importance of this proximity for enhancer...
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Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation
BackgroundT cell activation and programming from their naïve/resting state, characterized by widespread modifications in chromatin accessibility...
