Search
Search Results
-
-
Alpha-synuclein in peripheral body fluid as a biomarker for Parkinson’s disease
ObjectiveWhether alpha-synuclein in peripheral body fluids can be used for the diagnosis of Parkinson’s disease (PD) remains in controversy. This...
-
The Role of Alpha-Synuclein in Neurodevelopmental Diseases
Neurodevelopmental disorders are a group of diseases with cognitive, motor, and emotional development deficits. Alpha-synuclein (α-syn) is a synaptic...
-
Effect of Clemizole on Alpha-Synuclein-Preformed Fibrils-Induced Parkinson’s Disease Pathology: A Pharmacological Investigation
Parkinson’s disease (PD) is a neurodegenerative disorder associated with mitochondrial dysfunctions and oxidative stress. However, to date,...
-
Peptide-based approaches to directly target alpha-synuclein in Parkinson’s disease
Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly for intracellular protein-protein interactions too large...
-
Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by mitochondrial dysfunction and accumulation of alpha-synuclein...
-
Enhanced Spine Stability and Survival Lead to Increases in Dendritic Spine Density as an Early Response to Local Alpha-Synuclein Overexpression in Mouse Prefrontal Cortex
Lewy Body Dementias (LBD), including Parkinson’s disease dementia and Dementia with Lewy Bodies, are characterized by widespread accumulation of...
-
Distribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis
Synucleinopathies are neurodegenerative diseases characterized by pathological inclusions called “Lewy pathology” (LP) that consist of aggregated...
-
Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
BackgroundParkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn)...
-
Alpha-synuclein aggregates are phosphatase resistant
Alpha-synuclein (αsyn) is an intrinsically disordered protein that aggregates in the brain in several neurodegenerative diseases collectively called...
-
Cell-to-cell transmitted alpha-synuclein recapitulates experimental Parkinson’s disease
Parkinson’s disease is characterized by a progressive accumulation of alpha-Synuclein (αSyn) neuronal inclusions called Lewy bodies in the nervous...
-
Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases
The abnormal aggregation and accumulation of alpha-synuclein (aSyn) in the brain is a defining hallmark of synucleinopathies. Various aSyn...
-
Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy
Parkinson’s disease (PD) is a neurodegenerative disease characterized by progressive motor symptoms and alpha-synuclein (αsyn) aggregation in the...
-
Microglial inhibition alleviates alpha-synuclein propagation and neurodegeneration in Parkinson’s disease mouse model
The accumulation of alpha-synuclein (αSyn) is widely recognized as the main pathological process in Parkinson’s disease (PD). Additionally,...
-
In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson’s disease
Direct targeting of alpha-synuclein (ASYN) has emerged as a disease-modifying strategy for Parkinson’s disease and other synucleinopathies which is...
-
Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders
The alpha-synuclein (aSyn) seed amplification assay (SAA) can identify aSyn aggregates as indicator for Lewy body pathology in biomaterials of living...
-
Alpha-synuclein Immunization Strategies for Synucleinopathies in Clinical Studies: A Biological Perspective
The therapeutic strategies currently available for neurodegenerative diseases such as Parkinson’s disease target only the symptoms of the disease....
-
Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms
Growing evidence indicates that the pathological alpha-synuclein (α-syn) aggregation in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB)...
-
Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models
BackgroundLysosomal dysfunction has been implicated in a number of neurodegenerative diseases such as Parkinson’s disease (PD). Various molecular,...
-
Alpha-synuclein: a pathological factor with Aβ and tau and biomarker in Alzheimer’s disease
BackgroundAlpha-synuclein (α-syn) is considered the main pathophysiological protein component of Lewy bodies in synucleinopathies. α-Syn is an...
