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Investigation of alpha amylase inhibitors from Bidens pilosa L. by in silico and in vitro studies
Bidens pilosa L. has been traditionally used as an anti-diabetic herbal medicine; however, its mechanism of action remains elusive. In this study,...
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Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer’s dementia
BackgroundPrevious studies have shown that copy number variation (CNV) in the alpha (α)-amylase gene ( AMY1A ) is associated with body mass index,...
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Sex differences in neuroendocrine, sympathetic nervous system, and affect responses to acute stress in cannabis users
RationaleCannabis is the most widely used illicit substance in the USA and is often reportedly used for stress reduction. Indeed, cannabinoids...
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The effects of hydrocortisone and yohimbine on human behavior in approach-avoidance conflicts
RationaleBalancing approach of positive and avoidance of negative stimuli is essential when faced with approach-avoidance conflicts, e.g., situations...
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In-vitro evaluation of antimicrobial, antioxidant, alpha-amylase inhibition and cytotoxicity properties of Cannabis sativa
Cannabis sativa ( C. sativa ) is a widespread medicinal plant used for humans and cattles infectious diseases. The current study is carried out to...
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Climatic Factors and Allele Distribution of Amy 1 and Amy 2 Loci in the Varieties of Spring Barley in the Territory of the Former Soviet Union
AbstractThe alpha-amylase isozymes in barley are controlled by the Amy 1 and Amy 2 loci located on chromosomes 6 and 1 (=6H and 7H), respectively....
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In vitro and in silico inhibition of α-amylase, α-glucosidase, and aldose reductase by the leaf and callus extracts of Vernonia anthelmintica (L.) Willd.
In the present study, the leaf and callus extracts of Vernonia anthelmintica prepared in three different solvents (methanol, ethyl acetate, and...
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Animal Experiments of Anti-Diabetic Activities
Diabetes is a metabolic disorder classified into Type 1 and Type 2, and characterized with hyperglycaemia along with the disturbances in the...
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Attentional bias in individuals with depression and adverse childhood experiences: influence of the noradrenergic system?
RationaleMajor depressive disorder (MDD) is a severe mental disorder with affective, cognitive, and somatic symptoms. Mood congruent cognitive...
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Level of alpha amylase activity in human saliva as a non-invasive biochemical marker of sleep deprivation
To investigate the usefulness of the enzyme salivary alpha amylase as a biochemical marker of sleep deprivation in human subjects. Total 168 healthy...
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Design, synthesis and in silico evaluation of benzoxazepino(7,6-b)quinolines as potential antidiabetic agents
The second-generation XPhos palladium preformed catalyst-based C–N cross-coupling through Buchwald–Hartwig amination with primary and secondary...
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Anti-diabetic, anti-pancreatic lipase, and anti-protein glycation potential of Irvingia gabonensis stem bark extracts: in vitro and in silico studies
Diabetes mellitus is a chronic metabolic disorder that affects glucose, lipid, and protein metabolism. Targeting these metabolic derangements can...
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Gut microbiota-related metabolite alpha-linolenic acid mitigates intestinal inflammation induced by oral infection with Toxoplasma gondii
BackgroundOral infection with cysts is the main transmission route of Toxoplasma gondii ( T. gondii ), which leads to lethal intestinal inflammation....
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Enzymatic Biosensors for Detection of Pancreatitis
Pancreatitis is an inflammation of the pancreas due to infection, alcohol abuse or trauma. The biomarkers for pancreatitis are α-amylase and lipase...
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Dihydroquercetin: known antioxidant—new inhibitor of alpha-amylase activity
This paper describes the ability of a powerful antioxidant dihydroquercetin (DHQ) as a new inhibitor of the alpha-amylase. The enzyme activity was...
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Enzymatic Biosensors for Healthcare Applications
Biosensors have been employed for disease detection, diagnosis, and human health monitoring and management. Enzymes have received tremendous...
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Sleep Disorders: Identifying Biomarkers and Clinical Applications
In recent years, there was a surge in interest for biomarkers in sleep disorders. In this chapter we will focus on biomarkers with potential use in...
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α-Glucosidase Inhibitors for Diabetes/Blood Sugar Regulation
According to a recent analysis, nearly 450 million people get affected by type 2 diabetes, which corresponds to 6.28% of our population. Type 2...
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Metagenome Mining Approaches for the Discovery of Marine Microbial Natural Products
Microbial natural products (NPs) are a group of specialized metabolites produced by microorganisms such as Archaea, Bacteria, Fungi, and Microalgae...
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Role of Salivary Markers for Diagnosis of Systemic Diseases
Detection of disease by salivary testing is becoming more significant in dentistry, physiology, and medicine, as well as in endocrinology,...