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Population pharmacokinetic modeling and dosing simulation of avalglucosidase alfa for selecting alternative dosing regimen in pediatric patients with late-onset pompe disease
Avalglucosidase alfa (AVAL) was approved in the United States (2021) for patients with late-onset Pompe disease (LOPD), aged ≥ 1 year. In the present...
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Current trends and future directions for the synthesis and pharmacological applications of 2-(2-cyanopyrrolidin-1-yl)-N-3-hydroxyadamantan-1-yl) acetamide (Gliptins)
Dipeptidyl peptidase 4 (DPP-4), well known as the T-cell antigen CD26 enzyme which, was discovered in the year of 1966 by Hopsu-Havu and Glenner. The...
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Population pharmacokinetics of primaquine and its metabolites in African males
BackgroundPrimaquine (PQ) is the prototype 8-aminoquinoline drug, a class which targets gametocytes and hypnozoites. The World Health Organization...
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R-praziquantel integrated population pharmacokinetics in preschool- and school-aged African children infected with Schistosoma mansoni and S. haematobium and Lao adults infected with Opisthorchis viverrini
Racemic praziquantel (PZQ) is the standard treatment for schistosomiasis and liver fluke infections (opisthorchiasis and clonorchiasis). The...
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Facial and body sexual dimorphism are not interconnected in the Maasai
BackgroundIn this paper, we investigate facial sexual dimorphism and its’ association with body dimorphism in Maasai, the traditional seminomadic...
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Pharmacokinetics of PEGasparaginase in Infants with Acute Lymphoblastic Leukemia
BackgroundPEGasparaginase is known to be a critical drug for treating pediatric acute lymphoblastic leukemia (ALL), however, there is insufficient...
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The allometry of cellular DNA and ribosomal gene content among microbes and its use for the assessment of microbiome community structure
BackgroundThe determination of taxon-specific composition of microbiomes by combining high-throughput sequencing of ribosomal genes with...
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Relationship between body size and sexual size dimorphism in syringophilid quill mites
A positive relationship of body size and sexual size dimorphism (males’ size relative to females), called Rensch’s rule, is often observed in...
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A Population Pharmacokinetic Modelling Approach to Unravel the Complex Pharmacokinetics of Vincristine in Children
BackgroundVincristine, a chemotherapeutic agent that extensively binds to β-tubulin, is commonly dosed at 1.4–2.0 mg/m 2 capped at 2 mg. For infants,...
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Unveiling the neuroanatomy of Josephoartigasia monesi and the evolution of encephalization in caviomorph rodents
Caviomorph rodents are an exceptional model for studying the effects of ecological factors and size relations on brain evolution. These mammals are...
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Population pharmacokinetics of cyclosporine A in pediatric patients with thalassemia undergoing allogeneic hematopoietic stem cell transplantation
PurposeTo establish the population pharmacokinetics (PPK) model of cyclosporine A(CsA) in pediatric patients with thalassemia undergoing allogeneic...
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When will the Glomerular Filtration Rate in Former Preterm Neonates Catch up with Their Term Peers?
AimsWhether and when glomerular filtration rate (GFR) in preterms catches up with term peers is unknown. This study aims to develop a GFR maturation...
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Preclinical Pharmacokinetic and Pharmacodynamic Investigation of 5’-Methoxynobiletin from Ageratum conyzoides: In vivo and In silico Approaches
Purpose5’-methoxynobiletin (5’-MeONB), a polymethoxyflavone isolated from A. conyzoides , has shown anti-inflammatory property. Nevertheless, the...
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The Development of Aerobic and Anaerobic Fitness with Reference to Youth Athletes
PurposeTo challenge current conventions in paediatric sport science and use data from recent longitudinal studies to elucidate the development of...
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Monoclonal Antibodies: From Structure to Therapeutic Application
The exciting field of therapeutic monoclonal antibodies (mAbs) had its origins when Köhler and Milstein presented their murine hybridoma technology...
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Population Pharmacokinetic Modeling of Lucitanib in Patients with Advanced Cancer
BackgroundLucitanib is an oral, potent, selective inhibitor of the tyrosine kinase activity of vascular endothelial growth factor receptors 1‒3,...
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Population Pharmacokinetic Modeling and Dose Optimization of Acetaminophen and its Metabolites Following Intravenous Infusion in Critically ill Adults
Background and ObjectiveAcetaminophen (paracetamol) is a ubiquitously administered drug in critically ill patients. Considering the dearth of...
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Population Pharmacokinetic Modelling of Acetaminophen and Ibuprofen: the Influence of Body Composition, Formulation and Feeding in Healthy Adult Volunteers
Background and ObjectiveCombined acetaminophen and ibuprofen are common antipyretic and analgesic drugs. Formulation and feeding affect drug...
