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1. Design, synthesis, biochemical and in silico characterization of novel naphthalene-thiourea conjugates as potential and selective inhibitors of alkaline phosphatase

   Naphthalene ring is present in a number of FDA-approved, commercially available medications, including naphyrone, terbinafine, propranolol, naproxen,...

   Aamer Saeed, Saba Ashraf, ... Hesham R. El-Seedi in Medicinal Chemistry Research

   Article 10 April 2023
   

2. Detection of Pyrophosphate and Alkaline Phosphatase Activity Based on PolyT Single Stranded DNA - Copper Nanoclusters

   The determination of pyrophosphate and alkaline phosphatase activity plays a significant role in medical diagnosis. In this work, a label-free...

   Liu Yao, **n Li, ... Yonghong Wang in Journal of Fluorescence

   Article 01 July 2022
   

3. A Ratiometric Fluorescence Biosensor for Detection of Alkaline Phosphatase Via an Advanced Chemometric Model

   In this paper, a ratiometric fluorescence biosensor was introduced for alkaline phosphatase (ALP) detection based on 2-aminopurine (2-Amp) and...

   Yao Chen, **g-**g Han, ... Tong Wang in Journal of Fluorescence

   Article 23 October 2023
   

4. Exploring thiazole-linked thioureas using alkaline phosphatase assay, biochemical evaluation, computational analysis and structure–activity relationship (SAR) studies

   This study was carried out to identify the synthesis of a new group of thiazole-linked thioureas with aromatic and aliphatic side chains ( 4a – k ) using...

   Sajid Ali Channar, Pervaiz Ali Channar, ... Parvez Ali Mahesar in Medicinal Chemistry Research

   Article 13 August 2022
   

5. Fluorescent Turn-On Sensing of Zinc(II) and Alkaline Phosphatase Activity Using a Pyridoxal-5’-Phosphate Derived Schiff Base

   A novel Zn ²⁺ ion and alkaline phosphatase (ALP) selective fluorescence turn-on sensor L was developed by reacting pyridoxal 5’-phosphate (PLP) with...

   Amit Kumar, Yachana Upadhyay, ... Suban K. Sahoo in Journal of Fluorescence

   Article 04 May 2023
   

6. Nitrogen and Sulfur Co-doped Carbon Quantum Dots for Detecting Fe³⁺, Ascorbic Acid and Alkaline Phosphatase Activities

   A method utilizing nitrogen-doped and sulfur-doped carbon quantum dots (N, S-CQDs) as fluorescent probes for the rapid detection of Fe ³⁺ , L-ascorbic...

   Runuo Wang, Yang Wang, ... Longshan Zhao in Journal of Fluorescence

   Article 14 December 2023
   

7. Alkaline Phosphatases

   in Dictionary of Toxicology

   Reference work entry 2024
   

8. The effect of osteoporotic and non-osteoporotic individuals’ T cell-derived exosomes on osteoblast cells’ bone remodeling related genes expression and alkaline phosphatase activity

   Objectives

   Osteoporosis is a common skeletal disorder attributed to age and is defined as a systematic degradation of bone mass and the...

   Mohammad Hasan Omidvar, Mohammad Sadegh Soltani-Zangbar, ... Mehdi Yousefi in BMC Research Notes

   Article Open access 08 August 2022
   

9. Fluorescence Turn-on Detection of Alkaline Phosphatase Activity and Al³⁺ Using Vitamin B₆ Cofactor Conjugated GSH Capped Mn-doped ZnS Quantum Dots

   The glutathione (GSH) functionalized Mn-doped ZnS quantum dots (GSH_Mn_ZnS QDs) was conjugated with pyridoxal 5’-phosphate (PLP). The –CHO group of...

   Sonkeshriya Dhanshri, Suban K. Sahoo in Journal of Fluorescence

   Article 02 December 2022
   

10. Alpha-synuclein aggregates are phosphatase resistant

    Alpha-synuclein (αsyn) is an intrinsically disordered protein that aggregates in the brain in several neurodegenerative diseases collectively called...

    S. G. Choi, T. Tittle, ... B. A. Killinger in Acta Neuropathologica Communications

    Article Open access 31 May 2024
    

11. The prognostic potential of alkaline phosphatase and lactic acid dehydrogenase in bmCRPC patients without significant PSA response under enzalutamide

    Background

    In patients with bone metastatic castration-resistant prostate cancer (bmCRPC) on systemic treatment, it is difficult to differentiate...

    Renata Poteska, Kambiz Rahbar, ... Katrin Schlack in BMC Cancer

    Article Open access 08 April 2022
    

12. Elevation of alkaline phosphatase and long-term drug therapy for cystic fibrosis

    Quentin Delmez, Vincent Haufroid, ... Philippe Hantson in European Journal of Clinical Pharmacology

    Article 15 January 2022
    

13. Alkaline phosphatase downregulation promotes lung adenocarcinoma metastasis via the c-Myc/RhoA axis

    Background

    Lung adenocarcinoma (LUAD) metastasis significantly reduces patient survival; hence inhibiting the metastatic ability of lung cancer cells...

    Zhefeng Lou, Weiwei Lin, ... Lingling Zhao in Cancer Cell International

    Article Open access 15 April 2021
    

14. Albumin-to-alkaline phosphatase ratio as a promising indicator of prognosis in human cancers: is it possible?

    Background

    The impact of albumin-to-alkaline phosphatase ratio (AAPR) on prognosis in cancer patients remains uncertain, despite having multiple...

    Lin An, Wei-tian Yin, Da-wei Sun in BMC Cancer

    Article Open access 08 March 2021
    

15. Tissue alkaline phosphatase activity and expression in an experimental infant swine model of cardiopulmonary bypass with deep hypothermic circulatory arrest

    Background

    Infant cardiac surgery with cardiopulmonary bypass results in decreased circulating alkaline phosphatase that is associated with poor...

    Ludmila Khailova, Justin Robison, ... Jesse A. Davidson in Journal of Inflammation

    Article Open access 12 August 2020
    

16. Alkaline shear-thinning micro-nanocomposite hydrogels initiate endogenous TGFβ signaling for in situ bone regeneration

    Recruiting endogenous stem cells to bone defects without stem cell transplantation and exogenous factor delivery represents a promising strategy for...

    Yuting Niu, Zhen Yang, ... Yongsheng Zhou in npj Regenerative Medicine

    Article Open access 13 October 2023
    

17. Physico-chemistry and Cytotoxicity of Tenofovir-Loaded Acid Phosphatase-Responsive Chitosan Nanoparticles

    This study assesses the in vitro release of tenofovir (TFV)-loaded triphosphate ( TPP ) cross-linked chitosan nanoparticles (NPs) catalyzed by human...

    Albert Nguessan Ngo, James Murowchick, ... Bi-Botti Celestin Youan in AAPS PharmSciTech

    Article 23 June 2023
    

18. The plant-like protein phosphatase PPKL regulates parasite replication and morphology in Toxoplasma gondii

    Background

    The protozoan parasite Toxoplasma gondii encodes dozens of phosphatases, among which a plant-like phosphatase absent from mammalian...

    **-Ting Wu, Xu-Wen Gao, ... Shaojun Long in Parasites & Vectors

    Article Open access 18 March 2024
    

19. Ibuprofen taken before exercise blunts the IL-6 response in older adults but does not alter bone alkaline phosphatase or c-telopeptide

    Introduction

    Non-steroidal anti-inflammatory drugs (NSAIDs) taken before exercise have been shown to impair bone formation. NSAIDs also suppress...

    Sarah J. Wherry, Pamela Wolfe, ... Catherine M. Jankowski in European Journal of Applied Physiology

    Article 19 April 2021
    

20. Intestinal alkaline phosphatase modulation by food components: predictive, preventive, and personalized strategies for novel treatment options in chronic kidney disease

    Alkaline phosphatase (AP) is a ubiquitous membrane–bound glycoprotein that catalyzes phosphate monoesters’ hydrolysis from organic compounds, an...

    L. Alvarenga, L. F. M. F. Cardozo, ... D. Mafra in EPMA Journal

    Article 18 November 2020