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The Role of Glycated Albumin as a Biomarker of Glycemic Control in Diabetes and Chronic Kidney Disease
Albumin is the most abundant protein found in plasma and constitutes approximately 60% of all proteins in the blood. This high molecular weight...
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Morphological brain alterations in dialysis- and non-dialysis-dependent patients with chronic kidney disease
To 1) investigate the morphological brain-tissue changes in patients with dialysis- and non-dialysis-dependent chronic kidney disease (CKD); 2)...
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IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial
Inflammation mediated by interleukin-6 (IL-6) is strongly associated with cardiovascular risk. Here we evaluated clazakizumab, a monoclonal antibody...
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Albumin: a comprehensive review and practical guideline for clinical use
PurposeNowadays, it is largely accepted that albumin should not be used in hypoalbuminemia or for nutritional purpose. The most discussed indication...
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The Role of Glycated Albumin as a Biomarker of Glycemic Control in Diabetes and Chronic Kidney Disease
Albumin is the most abundant protein found in plasma and constitutes approximately 60% of all proteins in the blood. This high molecular weight...
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Determination of drug-related problems according to PAIR criteria in dialysis patients: a cross-sectional study in tertiary care hospital
BackgroundDialysis patients are at high risk for drug-related problems (DRPs), which have significant consequences for their morbidity, mortality,...
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Quality by design empowered preparation of itraconazole albumin nanoparticles for prostate cancer
The current advent explores the potential of itraconazole (ITR) in prostate cancer (PCa), by its incorporation into albumin nanoparticles (NP). ITR...
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A Quality by Design Paradigm for Albumin-Based Nanoparticles: Formulation Optimization and Enhancement of the Antitumor Activity
PurposeAlbumin nanoparticles are promising carriers for therapeutic agents, owing to their biocompatibility, safety, and versatility in fabrication....
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Exploring the synergistic behavior of paclitaxel and vorinostat upon co-loading in albumin nanoparticles for breast cancer management
Breast cancer is challenging to treat accompanied with poor clinical outcomes. Paclitaxel (PTX) is a first-line chemotherapeutic agent, but possesses...
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The Redox State of Serum Albumin as a Potential Protein Nutrition Biomarker
Albumin comprises the largest part of total serum proteins in humans and is exclusively synthesized in the liver, before being distributed into the...
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Human Serum Albumin-enriched Clopidogrel Bisulfate Nanoparticle Alleviates Cerebral Ischemia–Reperfusion Injury in Rats
PurposeCerebral ischemia – reperfusion (I/R) injury remains a leading cause of mobility and mortality among patients with ischemic stroke. This study...
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The Redox State of Serum Albumin as a Potential Protein Nutrition Biomarker
Albumin comprises the largest part of total serum proteins in humans and is exclusively synthesized in the liver, before being distributed into the...
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Albumin therapy for hepatic encephalopathy: current evidence and controversies
Hepatic encephalopathy (HE) is a common complication that occurs in 16–21% of end-stage cirrhosis patients. Emerging evidence suggests that systemic...
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Ciprofloxacin HCl-loaded Albumin Nanoparticles for the Treatment of Recurrent Urinary Tract Infections: Preparation, Optimization, and Evaluation of Antibacterial Activity
PurposeThe present research aimed to describe a novel ciprofloxacin HCl-loaded bovine serum albumin nanoparticle formulation to improve the...
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Albumin-Embellished Arsenic Trioxide-Loaded Polymeric Nanoparticles Enhance Tumor Accumulation and Anticancer Efficacy via Transcytosis for Hepatocellular Carcinoma Therapy
Arsenic trioxide (ATO) has efficient anticancer effect on hepatocellular carcinoma (HCC) in clinical trials, but its off-target distribution and side...
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Acetylcholine Analog-Modified Albumin Nanoparticles for the Enhanced and Synchronous Brain Delivery of Saponin Components of Panax Notoginseng
BackgroundPanax notoginseng saponins (PNS) are commonly used first-line drugs for treating cerebral thrombosis and stroke in China. However, the...
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Berberine-loaded albumin nanoparticles reverse aflatoxin B1-induced liver hyperplasia
Hepatocellular carcinoma (HCC) can be produced from aflatoxin B1 (AFB1) administration. Although berberine (BER) acts as an anticancer agent and can...
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Investigations of the Interaction Mechanism Between Orphenadrine Hydrochloride and Bovine Serum Albumin by Spectroscopic and Voltammetric Techniques
The interaction of orphenadrine hydrochloride (ORD) with the model protein, bovine serum albumin (BSA), was investigated using a variety of...
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Predicting the Stability of Lyophilized Human Serum Albumin Formulations Containing Sucrose and Trehalose Using Solid-State NMR Spectroscopy: Effect of Storage Temperature on 1H T1 Relaxation Times
In a lyophilized protein/disaccharide system, the ability of the disaccharide to form a homogeneous mixture with the protein and to slow the protein...
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Risk factors for sleep disorders in patients undergoing peritoneal dialysis
Sleep disorders in patients with end-stage renal disease are common but have rarely been reported in previous studies. Therefore, we examined the...
