Search

Search Results

1. PI3K/Akt/mTOR-immunoreactive neurons in the rat mediobasal hypothalamus during aging

   The hypothalamus is the regulatory hub controlling homeostasis, reproduction, circadian rhythms and endocrine system. It is also involved in the...

   Lydia G. Pankrasheva, Polina A. Anfimova, ... Petr M. Masliukov in Neuroscience and Behavioral Physiology

   Article 01 October 2023
   

2. STEAP4 inhibits cisplatin-induced chemotherapy resistance through suppressing PI3K/AKT in hepatocellular carcinoma

   Chemotherapy resistance is the leading cause for hepatocellular carcinoma (HCC)-induced death. Exploring resistance generation mechanism is an urgent...

   Binhui ** Li in Cancer & Metabolism

   Article Open access 18 December 2023
   

3. Structure-based optimization of aminothiadiazole inhibitors of AKT

   We report here the discovery and structure-guided optimization of a novel series of AKT kinase inhibitors. Based on docking studies for the predicted...

   Deborah S. Mortensen, Sayee G. Hegde, ... Rama Krishna Narla in Medicinal Chemistry Research

   Article 25 May 2023
   

4. A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway

   Background

   Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer with high aggressive phenotype and poor prognosis. Accumulating...

   Bo Huang, Junwu Ren, ... Bin **ao in Molecular Cancer

   Article Open access 15 February 2024
   

5. Protein kinase B (AKT) upregulation and Thy-1-α_vβ₃ integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis

   Background

   In response to brain injury or inflammation, astrocytes undergo hypertrophy, proliferate, and migrate to the damaged zone. These changes,...

   Ramón Pérez-Núñez, Alejandro Chamorro, ... Lisette Leyton in Journal of Neuroinflammation

   Article Open access 06 January 2023
   

6. AKT inhibition sensitizes EVI1 expressing colon cancer cells to irinotecan therapy by regulating the Akt/mTOR axis

   Purpose

   Ecotropic viral integration site 1 (EVI1) is an oncogenic transcription factor that has been attributed to chemotherapy resistance in...

   Pradeepa, Voddu Suresh, ... Soumen Chakraborty in Cellular Oncology

   Article 14 July 2022
   

7. Photobiomodulation therapy moderates cancer cachexia-associated muscle wasting through activating PI3K/AKT/FoxO3a pathway

   Cancer cachexia-associated muscle wasting as a multifactorial wasting syndrome, is an important factor affecting the long-term survival rate of tumor...

   Yonghua Li, Yibing Chen, ... Zhengzhi Zou in Apoptosis

   Article 10 April 2024
   

8. Akt: a key transducer in cancer

   Growth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senescence, and migration and its...

   Pei-Jane Tsai, Yi-Hsin Lai, ... Hui-Kuan Lin in Journal of Biomedical Science

   Article Open access 01 October 2022
   

9. Targeting PI3K/Akt in Cerebral Ischemia Reperfusion Injury Alleviation: From Signaling Networks to Targeted Therapy

   Ischemia/reperfusion (I/R) injury is a pathological event that results in reperfusion due to low blood flow to an organ. Cerebral ischemia is a...

   Ting Zheng, Taotao Jiang, ... Manxia Wang in Molecular Neurobiology

   Article 05 March 2024
   

10. Endoxifen downregulates AKT phosphorylation through protein kinase C beta 1 inhibition in ERα+ breast cancer

    Endoxifen, a secondary tamoxifen metabolite, is a potent antiestrogen exhibiting estrogen receptor alpha (ERα) binding at nanomolar concentrations....

    Swaathi Jayaraman, **nyan Wu, ... Matthew P. Goetz in npj Breast Cancer

    Article Open access 19 December 2023
    

11. Urolithin C suppresses colorectal cancer progression via the AKT/mTOR pathway

    Urolithin families are gut-microbial metabolites of ellagic acid (EA). Although urolithin A (UA) and urolithin B (UB) were reported to have...

    Haochi Yang, Binghuo Wu, ... Chuan Xu in Journal of Natural Medicines

    Article Open access 07 June 2024
    

12. AKT Isoforms in the Immune Response in Cancer

    AKT is a protein kinase that exists in three isoforms: AKT1, AKT2, and AKT3. Though similar in structure, these isoforms display different effects....

    Zayd Ahmad, Payaningal R. Somanath in PI3K and AKT Isoforms in Immunity

    Chapter 2022
    

13. A bibliometric analysis of the application of the PI3K-AKT-mTOR signaling pathway in cancer

    PI3K-AKT-mTOR plays as important role in the growth, metabolism, proliferation, and migration of cancer cells, and in apoptosis, autophagy,...

    Zhengzheng Deng, Qiancheng Qing, Bo Huang in Naunyn-Schmiedeberg's Archives of Pharmacology

    Article 06 May 2024
    

14. PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

    The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell...

    Antonino Glaviano, Aaron S. C. Foo, ... Alan P. Kumar in Molecular Cancer

    Article Open access 18 August 2023
    

15. EVA1A reverses lenvatinib resistance in hepatocellular carcinoma through regulating PI3K/AKT/p53 signaling axis

    Lenvatinib is a commonly used first-line drug for the treatment of advanced hepatocellular carcinoma (HCC). However, its clinical efficacy is limited...

    **aokun Liu, **ao Gao, ... Ning Li in Apoptosis

    Article 14 May 2024
    

16. GCNT3 Promotes Hepatocellular Carcinoma Progression and EMT by Activating the PI3K/AKT Pathway

    Primary liver cancer, specifically hepatocellular carcinoma (HCC), is a major global health concern. GCNT3 has been identified as an oncogene in...

    Yadong Wang, **aosan Fang, ... **aoming Wang in Biochemical Genetics

    Article 24 May 2024
    

17. Knockdown of SETD5 Inhibits Colorectal Cancer Cell Growth and Stemness by Regulating PI3K/AKT/mTOR Pathway

    SET domain-containing 5 (SETD5), a member of protein lysine methyltransferase family, is expressed in multiple cancers, making it potential...

    **aohua Zhou, Wenqiang Chen, ... Hongqing Rui in Biochemical Genetics

    Article 19 April 2024
    

18. Downregulating DNA methyltransferase 3B by suppressing the PI3K/Akt signaling pathway enhances the chemosensitivity of glioblastoma to temozolomide

    Glioblastoma (GBM) is the most common malignant brain tumor and has the poorest prognosis attributed to its chemoresistance to temozolomide (TMZ),...

    Wenwu Kan, Linhui Gao, ... Cheng Wang in Molecular Neurobiology

    Article Open access 17 February 2024
    

19. Cardamomin Inhibits the Proliferation and Tumorigenesis of Bladder Cancer by ESR1 in PI3K/AKT Pathway

    Cardamomin has been widely studied in cancer, but its role in cancer bladder cancer has not been mentioned. In this study, we validated the...

    Peng Zhang, Dapeng Song, ... Xudong Jiang in Biochemical Genetics

    Article 12 June 2024
    

20. AKT Isoforms as a Target in Cancer and Immunotherapy

    Over the past years, targeted therapies have received tremendous attention in cancer therapy. One of the most frequently targeted pathways is the...

    Daniel J. Smit, Manfred Jücker in PI3K and AKT Isoforms in Immunity

    Chapter 2022