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The Role of P2Y6 Receptors in the Mechanisms of the Neuroprotective Effect of Citicoline
Spontaneous bioelectrical activity of the brain and the duration of gas** were recorded in mice during modeling of global strangulation ischemia of...
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Charting the Next Road Map for CSF Biomarkers in Alzheimer’s Disease and Related Dementias
Clinical prediction of underlying pathologic substrates in people with Alzheimer’s disease (AD) dementia or related dementia syndromes (ADRD) has...
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MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects
Mesencephalic astrocyte-derived neurotrophic factor (MANF) has cytoprotective effects on various injuries, including cerebral ischemia, and it can...
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Adult human neurogenesis: early studies clarify recent controversies and go further
Evidence on adult mammalian neurogenesis and scarce studies with human brains led to the idea that adult human neurogenesis occurs in the subgranular...
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Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain
A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues into single-cell suspensions. While many protocols...
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Molecular Determinants of Neurocognitive Deficits in Glioma: Based on 2021 WHO Classification
Cognitive impairment is a common feature among patients with diffuse glioma. The objective of the study is to investigate the relationship between...
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Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice
The neural functions of adropin, a secreted peptide highly expressed in the brain, have not been investigated. In humans, adropin is highly expressed...
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Autopsy Biobanking: Biospecimen Procurement, Integrity, Storage, and Utilization
An autopsy is a specialized surgical procedure consisting of external and internal examination of a deceased individual for the purposes of...
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Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia
Reductions in the GABAergic neurotransmitter system exist across multiple brain regions in schizophrenia and encompass both pre- and postsynaptic...
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Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation
Mitochondrial function is required for brain energy homeostasis and neuroadaptation. Recent studies demonstrate that cocaine affects mitochondrial...
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Genomics, convergent neuroscience and progress in understanding autism spectrum disorder
More than a hundred genes have been identified that, when disrupted, impart large risk for autism spectrum disorder (ASD). Current knowledge about...
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Modeling Chronic Coccidioidomycosis in Mice
Coccidioidomycosis, caused by the dimorphic pathogens Coccidioides posadasii and C. immitis, is a fungal disease endemic to the southwestern United...
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MicroRNA-650 Regulates the Pathogenesis of Alzheimer’s Disease Through Targeting Cyclin-Dependent Kinase 5
Alzheimer’s disease (AD) pathogenesis feature progressive neurodegeneration, amyloid-β plaque formation, and neurofibrillary tangles. Ample evidence...
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Essential Tremor
The term “essential tremor” was first used by European physicians in the later decades of the nineteenth century to describe an inherited,...
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Map** the primate thalamus: systematic approach to analyze the distribution of subcortical neuromodulatory afferents
Neuromodulatory afferents to thalamic nuclei are key for information transmission and thus play critical roles in sensory, motor, and limbic...
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Mitochondrial Dysfunction in Rabies Virus-Infected Human and Canine Brains
Rabies is a fatal encephalitis caused by the Rabies lyssavirus (RABV). The presence of minimal neuropathological changes observed in rabies indicates...
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Characteristics of the tissue section that influence the staining outcome in immunohistochemistry
Immunohistochemistry (IHC) is influenced by several factors such as cold ischemia time, fixative, fixation time, paraffin, storage time, antibody,...
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Necropsy Procedures and Evaluation of Macroscopic Lesions of Pigs Infected with African Swine Fever Virus
Pathology complements and provides a fundamental link to other disciplines for disease investigations supporting molecular biology, genetics,...
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Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue
The MAPT gene, encoding the microtubule-associated protein tau on chromosome 17q21.31, is result of an inversion polymorphism, leading to two allelic...
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Correlation of Postmortem Changes with Time Since Death
This chapter explores in detail all the changes occurring after death in a dead body and how and why such changes take place, and what are the causes...