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The role of immunosuppressive myofibroblasts in the aging process and age-related diseases
Tissue-resident fibroblasts are mesenchymal cells which control the structural integrity of the extracellular matrix (ECM). Fibroblasts possess a...
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The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseases
AbstractThe accumulation of senescent cells within tissues is a hallmark of the aging process. Senescent cells are also commonly present in many...
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Dietary flavonoids intake contributes to delay biological aging process: analysis from NHANES dataset
BackgroundDiet may influence biological aging and the discrepancy (∆age) between a subject’s biological age (BA) and chronological age (CA). We aimed...
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When Maturation is Not Linear: Brain Oscillatory Activity in the Process of Aging as Measured by Electrophysiology
Changes in brain oscillatory activity are commonly used as biomarkers both in cognitive neuroscience and in neuropsychiatric conditions. However,...
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Subcutaneous adipose tissue alteration in aging process associated with thyroid hormone signaling
BackgroundFunctional changes in subcutaneous adipose tissue (SAT) occur earlier in the aging process and play an important role in the occurrence and...
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Aging and cancer
Aging and cancer exhibit apparent links that we will examine in this review. The null hypothesis that aging and cancer coincide because both are...
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Repurposing of Drugs in Aging
Aging is a complex biological process characterized by a gradual decline in physiological functions and an increased susceptibility to age-related...
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Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin
BackgroundExcessive exposure of the skin to UV radiation (UVR) triggers a remodeling of the immune system and leads to the photoaging state which is...
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Distinguishing between driver and passenger mechanisms of aging
Understanding why we age is a long-standing question, and many mechanistic theories of aging have been proposed. Owing to limitations in studying the...
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Aging and Cancer
In this chapter, we will discuss aging as the progressive decline in the function of cells, tissues and organs that leads to impaired functions of...
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Ethnopharmacology: A Boon for Brain Aging
Aging is a universal process that is beyond the scope of human control. It cannot be stopped because it is a natural occurrence. Before the...
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Nutraceuticals in Alleviating Aging
Aging is a physiological process characterized by the loss of biological functions such as senescence and is associated with degenerative diseases....
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IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in d-galactose-induced aging mice
BackgroundLiver aging, marked by cellular senescence and low-grade inflammation, heightens susceptibility to chronic liver disease and worsens its...
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Validation of biomarkers of aging
The search for biomarkers that quantify biological aging (particularly ‘omic’-based biomarkers) has intensified in recent years. Such biomarkers...
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ABI3BP promotes renal aging through Klotho-mediated ferroptosis
The aging process of the kidneys is accompanied with several structural diseases. Abnormal fiber formation disrupts the balance of kidney structure...
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Biomolecular Markers of Brain Aging
Characterized by the gradual loss of physiological integrity, impaired function, and increased susceptibility to death, aging is considered the...
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A high-resolution view of the heterogeneous aging endothelium
Vascular endothelial cell (EC) aging has a strong impact on tissue perfusion and overall cardiovascular health. While studies confined to the...
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How calorie restriction slows aging: an epigenetic perspective
Genomic instability and epigenetic alterations are some of the prominent factors affecting aging. Age-related heterochromatin loss and decreased...
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Multimodal Omics Approaches to Aging and Age-Related Diseases
Aging is associated with a progressive decline in physiological capacities and an increased risk of aging-associated disorders. An increasing body of...
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Impact of NAD+ metabolism on ovarian aging
Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox reactions, is closely associated with age-related functional...
