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The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing
Ageing is a crucial risk factor for Alzheimer’s disease (AD) and is characterised by systemic changes in both intracellular and extracellular...
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Effects of ageing and frailty on circulating monocyte and dendritic cell subsets
Ageing is associated with dysregulated immune responses, resulting in impaired resilience against infections and low-grade inflammation known as...
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Healthy ageing: Herpes zoster infection and the role of zoster vaccination
Populations are ageing worldwide, with considerable time lived in ill-health, putting upwards pressure on healthcare budgets. Healthy ageing is...
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Association between life’s essential 8 and biological ageing among US adults
BackgroundBiological ageing is tightly linked to cardiovascular disease (CVD). We aimed to investigate the relationship between Life’s Essential 8...
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An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo
BackgroundRestraining or slowing ageing hallmarks at the cellular level have been proposed as a route to increased organismal lifespan and...
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Brain structural covariances in the ageing brain in the UK Biobank
The morphologic properties of brain regions co-vary or correlate with each other. Here we investigated the structural covariances of cortical...
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True Ageing: An Up-to-date Model for Evaluating the Immune Age of the Chinese Population
The pursuit of immortality has always been a long-standing aspiration of humanity. However, with increasing age comes the unexpected onset of aging....
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Immune-Ageing Evaluation of Peripheral T and NK Lymphocyte Subsets in Chinese Healthy Adults
Ageing is often accompanied with a decline in immune system function, resulting in immune ageing. Numerous studies have focussed on the changes in...
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Ageing and Vasoreactivity
Increasing deterioration of the vasculature, both structurally and functionally, occurs with ageing. Although these changes are a natural process,...
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Impaired angiogenesis in ageing: the central role of the extracellular matrix
Each step in angiogenesis is regulated by the extracellular matrix (ECM). Accumulating evidence indicates that ageing-related changes in the ECM...
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Persistent accelerated epigenetic ageing in a longitudinal cohort of vertically infected HIV-positive adolescents
We have previously shown accelerated ageing in adolescents perinatally infected with HIV (PHIV +), based on discrepancies between epigenetic and...
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Ageing restructures the transcriptome of the hypothalamic supraoptic nucleus and alters the response to dehydration
Ageing is associated with altered neuroendocrine function. In the context of the hypothalamic supraoptic nucleus, which makes the antidiuretic...
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Neuroprotective Effects of Phytochemicals in Brain Ageing
This book discusses the mechanism and therapeutic strategies of phytochemicals against brain ageing. It discusses the underlying anti-oxidative and...
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Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has been associated with a broad range of age-related diseases,...
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Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing
BackgroundThe gut microbiota is associated with diverse age-related disorders. Several rejuvenation methods, such as probiotic administration and...
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Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer
BackgroundResearch has suggested significant correlations among ageing, immune microenvironment, inflammation and tumours. However, the relationships...
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Accelerated immune ageing is associated with COVID-19 disease severity
BackgroundThe striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the...
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Gut Microbiome: A Key Factor in Ageing and an Aim for Anti-senescence Intervention
The ageing process is increasingly being attributed to the gut microbiome. It has been hypothesized that age-related gut dysbiosis is influenced by...
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Genetic associations with healthy ageing among Chinese adults
The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study...
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Comparisons between wrinkles and photo-ageing detected and self-reported by the participant or identified by trained assessors reveal insights from Chinese individuals in the Singapore/Malaysia Cross-sectional Genetics Epidemiology Study (SMCGES) cohort
BackgroundChanges develop on the facial skin as a person ages. Other than chronological time, it has been discovered that gender, ethnicity, air...
