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Modeling global 80-80-80 blood pressure targets and cardiovascular outcomes
As the leading cause of death worldwide, cardiovascular diseases (CVDs) present major challenges for health systems. In this study, we analyzed the...
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Effectiveness of a second BNT162b2 booster vaccine against hospitalization and death from COVID-19 in adults aged over 60 years
The rapid emergence of the B.1.1.529 (Omicron) variant of SARS-CoV-2 led to a global resurgence of coronavirus disease 2019 (COVID-19). Israeli...
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Should we screen for colorectal cancer in people aged 75 and over? A systematic review - collaborative work of the French geriatric oncology society (SOFOG) and the French federation of digestive oncology (FFCD)
BackgroundWe have done a systematic literature review about CRC Screening over 75 years old in order to update knowledge and make recommendations.
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Immunosenescence and inflammaging in the aged horse
The equine population in the United States and worldwide now includes a higher percentage of geriatric horses than ever previously recorded, and as...
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Ischemic stroke after COVID-19 bivalent vaccine administration in patients aged 65 years and older in the United States
The Centers for Disease Control and Prevention announced in January 2023 a potential connection between administration of the Pfizer novel...
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Growth hormone reduces aneuploidy and improves oocytes quality by JAK2-MAPK3/1 pathway in aged mice
BackgroundThe global delay in women’s reproductive age has raised concerns about age-related infertility. The decline in oocyte quality is a limiting...
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Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice
BackgroundPatients with Alzheimer's disease (AD) develop blood–brain barrier dysfunction to varying degrees. How aging impacts Aβ pathology,...
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Uterine microbial communities and their potential role in the regulation of epithelium cell cycle and apoptosis in aged hens
BackgroundAlterations of the uterine microbiome are closely associated with various intrauterine diseases and physiological conditions, which are...
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A short dasatinib and quercetin treatment is sufficient to reinstate potent adult neuroregenesis in the aged killifish
The young African turquoise killifish has a high regenerative capacity, but loses it with advancing age, adopting several aspects of the limited form...
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A transversal cross-sectional study of factors related to HPV vaccination status and cancer screening participation among French women aged 25–40
BackgroundIn 2020, uterine cervical cancer (UCC) was the 12th most common cancer among women in France and the 4th worldwide. French health...
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Multicomponent intranasal adjuvant for mucosal and durable systemic SARS-CoV-2 immunity in young and aged mice
Multiple FDA-approved SARS-CoV-2 vaccines currently provide excellent protection against severe disease. Despite this, immunity can wane relatively...
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The acute effect of passively assisted trunk stretching on central arterial stiffness and blood pressure in middle-aged to older adults
PurposeWe examined the effects of acute trunk stretching on central arterial stiffness and central and peripheral blood pressure in middle-aged to...
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Long-term effects of a fat-directed FGF21 gene therapy in aged female mice
Fibroblast growth factor 21 (FGF21) has been developed as a potential therapeutic agent for metabolic syndromes. Moreover, FGF21 is considered a...
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The role of melatonin deficiency induced by pinealectomy on motor activity and anxiety responses in young adult, middle-aged and old rats
BackgroundAging affects anxiety levels in rats while the pineal gland, via its hormone melatonin, could modulate their inherited life “clock.” The...
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The effect of statins on falls and physical activity in people aged 65 and older: A systematic review
PurposeStatins are commonly prescribed medications with recognised side effects including muscle weakness. Despite this, little is known about their...
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Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice
One goal of regenerative medicine is to rejuvenate tissues and extend lifespan by restoring the function of endogenous aged stem cells. However,...
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Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice
Adenylyl cyclase 1 (AC1) is a selective subtype of ACs, which is selectively expressed in neurons. The activation of AC1 is activity-dependent, and...
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Parathyroid hormone stimulates bone regeneration in an atrophic non-union model in aged mice
BackgroundNon-union formation still represents a major burden in trauma and orthopedic surgery. Moreover, aged patients are at an increased risk for...
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Central nervous system-associated macrophages modulate the immune response following stroke in aged mice
Age is a major nonmodifiable risk factor for ischemic stroke. Central nervous system-associated macrophages (CAMs) are resident immune cells located...
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Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples
The past decade has witnessed increasing evidence for a crucial role played by glial cells, notably astrocytes, in Alzheimer’s disease (AD). To...
