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Agathisflavone Modifies Microglial Activation State and Myelination in Organotypic Cerebellar Slices Culture
AbstractOligodendrocytes produce the myelin that is critical for rapid neuronal transmission in the central nervous system (CNS). Disruption of...
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The Flavonoid Agathisflavone from Poincianella pyramidalis Prevents Aminochrome Neurotoxicity
Flavonoids have been suggested to protect dopaminergic neurons in Parkinson’s disease based on studies that used exogenous neurotoxins. In this...
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Agathisflavone modulates astrocytic responses and increases the population of neurons in an in vitro model of traumatic brain injury
Traumatic brain injury (TBI) is a critical health problem worldwide, with a high incidence rate and potentially severe long-term consequences....
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Phytochemicals and Nutraceuticals Targeting SARS-CoV-2: An In Silico Analysis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a global pandemic in the past years and is still a global disaster. Some...
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Flavonoids as Potential Therapeutics Against Neurodegenerative Disorders: Unlocking the Prospects
Neurodegeneration, the decline of nerve cells in the brain, is a common feature of neurodegenerative disorders (NDDs). Oxidative stress, a key factor...
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Unveiling Nature’s Arsenal: Natural Sources for Drug Discovery in Alzheimer’s Disease
Alzheimer’s disease (AD) imposes a significant global healthcare challenge, as it currently lacks a definitive cure. This devastating condition...
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Influenza A Virus Neuraminidase Inhibitors
Depending on the strain, influenza A virus causes animal, zoonotic, pandemic, or seasonal influenza with varying degrees of severity. Two surface...
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Therapeutic and Prophylactic Effects of Plant Derivatives Against SARS CoV-2
According to World Health Organization, the crucial health risk was caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and was...
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West African medicinal plants and their constituent compounds as treatments for viral infections, including SARS-CoV-2/COVID-19
ObjectivesThe recent emergence of the COVID-19 pandemic (caused by SARS-CoV-2) and the experience of its unprecedented alarming toll on humanity have...
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Computational assessment of select antiviral phytochemicals as potential SARS-Cov-2 main protease inhibitors: molecular dynamics guided ensemble docking and extended molecular dynamics
Covid-19 caused by novel coronavirus, 2019-nCoV or SARS-CoV-2 has become most severe pandemic of this century. No specific therapies are available to...
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Flavonoid as possible therapeutic targets against COVID-19: a sco** review of in silico studies
ObjectivesThis sco** review aims to present flavonoid compounds’ promising effects and possible mechanisms of action on potential therapeutic...
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Role of Herbal Formulations in Antiviral Therapy - an Overview
The incidence and prevalence of various viral infections have risen tremendously and remain a life-threatening risk to people over the past century....
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Protective Effects of Flavonoid Rutin Against Aminochrome Neurotoxicity
Causes of dopaminergic neuronal loss in Parkinson’s disease (PD) are subject of investigation and the common use of models of acute neurodegeneration...
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Traditional Herbal Medicines and Their Active Constituents in Combating SARS-CoV-2 Infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third coronavirus to cause a global pandemic of significant human illnesses in...
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Isolation and evaluation of antiviral plant compounds against respiratory disease-causing viruses: a review
Influenza viruses are major concern worldwide due to their fast ability to spread, and causing the respiratory illness of varying severity. The rate...
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Plant-Based Natural Products: Potential Anti-COVID-19 Agents
Viral infections are a continued threat for the human existence on globe. The danger is recently highlighted in the form of novel COVID-19 epidemic...
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Zebrafish as a Promising Tool for Modeling Neurotoxin-Induced Alzheimer’s Disease
Drug discovery and development for Alzheimer’s disease (AD) are complex and challenging due to the higher failure rate in the drug development...
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Promising Antimicrobial Agents from Some Latin American Medicinal Plants Against Disease-Causing Pathogens in Humans and Animals
According to WHO and FAO, the current global problem in public health/environmental which is of high economic impact is the lack of...
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Alzheimer’s disease: natural products as inhibitors of neuroinflammation
Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and...
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