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IBD sharing patterns as intra-breed admixture indicators in small ruminants
In this study, we investigated how IBD patterns shared between individuals of the same breed could be informative of its admixture level, with the...
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Exploring the relationship between admixture and genetic susceptibility to attention deficit hyperactivity disorder in two Latin American cohorts
Contemporary research on the genomics of Attention Deficit Hyperactivity Disorder (ADHD) often underrepresents admixed populations of diverse genomic...
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The role of admixture in the rare variant contribution to inflammatory bowel disease
BackgroundIdentification of rare variants involved in complex, polygenic diseases like Crohn’s disease (CD) has accelerated with the introduction of...
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Fast and accurate population admixture inference from genotype data from a few microsatellites to millions of SNPs
Model-based (likelihood and Bayesian) and non-model-based (PCA and K -means clustering) methods were developed to identify populations and assign...
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Multiple founding paternal lineages inferred from the newly-developed 639-plex Y-SNP panel suggested the complex admixture and migration history of Chinese people
BackgroundNon-recombining regions of the Y-chromosome recorded the evolutionary traces of male human populations and are inherited...
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Cross-continental admixture in the Kho population from northwest Pakistan
Northern Pakistan is home to many diverse ethnicities and languages. The region acted as a prime corridor for ancient invasions and population...
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Admixture map** reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer’s disease in Caribbean Hispanics
BackgroundGenetic studies have primarily been conducted in European ancestry populations, identifying dozens of loci associated with late-onset...
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Admixture map** of anthropometric traits in the Black Women’s Health Study: evidence of a shared African ancestry component with birth weight and type 2 diabetes
Prevalence of obesity, type 2 diabetes (T2D), and being born with low birth weight are much higher in African American women compared to U.S. white...
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Conventional and molecular pharmacognostic characters integrated with chemical profiles of five Piper plants in the Thai herbal pharmacopoeia and their admixture/adulteration/substitution situations in Thailand
The morphological and microscopy were combined with DNA-barcoding, together with rapid TLC for the characterization of Piper betle (PB), P. nigrum ...
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Admixture map** identifies African and Amerindigenous local ancestry loci associated with fetal growth
Fetal growth is an important determinant of cardiometabolic disease risk during childhood and adulthood. The genetic architecture of fetal growth...
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Large-scale genome-wide SNP analysis reveals the rugged (and ragged) landscape of global ancestry, phylogeny, and demographic history in chicken breeds
The worldwide chicken gene pool encompasses a remarkable, but shrinking, number of divergently selected breeds of diverse origin. This study was a...
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Single haplotype admixture models using large scale HLA genotype frequencies to reproduce human admixture
The human leukocyte antigen (HLA) is the most polymorphic region in humans. Anthropologists use HLA to trace populations’ migration and evolution....
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Dual origins of the Northwest Chinese Kyrgyz: the admixture of Bronze age Siberian and Medieval Niru’un Mongolian Y chromosomes
The Kyrgyz are a trans-border ethnic group, mainly living in Kyrgyzstan. Previous genetic investigations of Central Asian populations have repeatedly...
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Genetic Ancestry Inference for Pharmacogenomics
Genetic ancestry inference can be used to stratify patient cohorts and to model pharmacogenomic variation within and between populations. We provide...
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The genomic analysis of current-day North African populations reveals the existence of trans-Saharan migrations with different origins and dates
The Sahara Desert has acted as a barrier to human gene-flow between the northern and central parts of Africa since its aridification. Nonetheless,...
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Demographic history of Ryukyu islanders at the southern part of the Japanese Archipelago inferred from whole-genome resequencing data
The Ryukyu Islands are located in the southernmost part of the Japanese Archipelago and consist of several island groups. Each island group has its...
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Genome-wide allele and haplotype-sharing patterns suggested one unique Hmong–Mein-related lineage and biological adaptation history in Southwest China
BackgroundFine-scale genetic structure of ethnolinguistically diverse Chinese populations can fill the gap in the missing diversity and evolutionary...
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Pangenome analysis reveals genomic variations associated with domestication traits in broomcorn millet
Broomcorn millet ( Panicum miliaceum L.) is an orphan crop with the potential to improve cereal production and quality, and ensure food security. Here...
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Ancestry-driven metabolite variation provides insights into disease states in admixed populations
BackgroundMetabolic pathways are related to physiological functions and disease states and are influenced by genetic variation and environmental...
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Transmission disequilibrium analysis of whole genome data in childhood-onset systemic lupus erythematosus
Childhood-onset systemic lupus erythematosus (cSLE) patients are unique, with hallmarks of Mendelian disorders (early-onset and severe disease) and...