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Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors
Transactivation of receptor tyrosine kinases (RTK) is a crosstalk mechanism exhibited by G-protein–coupled receptors (GPCR) to activate signaling...
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The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors
Inosine has robust neuroprotective effects, but it is unclear if inosine acts as direct ligand of adenosine receptors or if it triggers metabolic...
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Feedback facilitation by adenosine A2A receptors of ATP release from mouse hippocampal nerve terminals
The adenosine modulation system is mostly composed by inhibitory A 1 receptors (A 1 R) and the less abundant facilitatory A 2A receptors (A 2A R), the...
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Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity
Retinopathy of prematurity (ROP) continues to pose a significant threat to the vision of numerous children worldwide, primarily owing to the...
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Heukharang (Lactuca sativa L.) extracts enhanced the sleep behavior of mice: potential involvement of adenosine A1 and A2A receptors
A significant proportion of the world’s population suffers from insomnia, a disorder characterized by complications in initiating and maintaining...
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The role of dorsomedial striatum adenosine 2A receptors in the loss of goal-directed behaviour
RationaleAdenosine A 2A receptors (A 2A R) in the dorsal striatum have been implicated in goal-directed behaviour. While activation of these receptors...
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Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease
Extracellular ATP can be a danger signal, but its role in striatal circuits afflicted in Parkinson’s disease (PD) is unclear and was now...
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The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors
Guanosine has been considered a promising candidate for antidepressant responses, but if this nucleoside could modulate adenosine A 1 (A 1 R) and A 2A (A 2A...
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In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs
Some non-adenosinergic drugs are reported to also act through adenosine receptors (ARs). We used mouse hypothermia, which can be induced by agonism...
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Coffee, adenosine, and the liver
A variety of observational studies have demonstrated that coffee, likely acting through caffeine, improves health outcomes in patients with chronic...
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Guanosine modulates K+ membrane currents in SH-SY5Y cells: involvement of adenosine receptors
Guanosine (GUO), widely considered a key signaling mediator, is implicated in the regulation of several cellular processes. While its interaction...
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Adenosine A2A Receptor-Containing Heteromers and Neuroprotection
Adenosine is a nucleoside with key functions in cell metabolism and in the regulation of several physiological processes in mammals. Its actions are...
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Neurobehavioral protective effects of Japanese sake yeast supplement against chronic stress-induced anxiety and depression-like symptoms in mice: Possible role of central adenosine receptors
RationaleUsing routine synthetic drugs in the treatment of psychiatric disorders may have some restrictions due to serious side effects and...
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The role of the ATP-adenosine axis in ischemic stroke
In ischemic stroke, the primary neuronal injury caused by the disruption of energy supply is further exacerbated by secondary sterile inflammation....
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Effect of adenosine treatment on ionizing radiation toxicity in zebrafish early life stages
The danger of ionizing radiation exposure to human health is a concern. Since its wide use in medicine and industry, the development of...
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Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells
BackgroundThe over-activation of adenosine A 2A receptors (A 2A R) is closely implicated in cognitive impairments of Alzheimer's disease (AD). Growing...
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Molecular and Structural Insight into Adenosine A2A Receptor in Neurodegenerative Disorders: A Significant Target for Efficient Treatment Approach
All biological tissues and bodily fluids include the autacoid adenosine. The P1 class of purinergic receptors includes adenosine receptors. Four...
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Upregulation of Src Family Tyrosine Kinases in the Rat Striatum by Adenosine A2A Receptors
Adenosine A 2A receptors are G olf -coupled receptors and are predominantly expressed in the striatum of mammalian brains. As a mostly postsynaptic...
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A2B adenosine receptor signaling and regulation
The A 2B adenosine receptor (A 2B R) is one of the four adenosine-activated G protein-coupled receptors. In addition to adenosine, protein kinase C...
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