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Targeting the A3 adenosine receptor to treat hepatocellular carcinoma: anti-cancer and hepatoprotective effects
The A3 adenosine receptor (A3AR) is over-expressed in human hepatocellular carcinoma (HCC) cells. Namodenoson, an A3AR agonist, induces de-regulation...
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Adenosine A2A Receptor-Containing Heteromers and Neuroprotection
Adenosine is a nucleoside with key functions in cell metabolism and in the regulation of several physiological processes in mammals. Its actions are...
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A2B adenosine receptor signaling and regulation
The A 2B adenosine receptor (A 2B R) is one of the four adenosine-activated G protein-coupled receptors. In addition to adenosine, protein kinase C...
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The role of adenosine A1 receptor on immune cells
BackgroundAdenosine, acting as a regulator by mediating the activation of G protein-coupled adenosine receptor families (A 1 , A 2 A, A 2 B, and A 3 ),...
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Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection
BackgroundStreptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia in older adults. Successful control of pneumococci requires robust...
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Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors
Transactivation of receptor tyrosine kinases (RTK) is a crosstalk mechanism exhibited by G-protein–coupled receptors (GPCR) to activate signaling...
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Molecular and Structural Insight into Adenosine A2A Receptor in Neurodegenerative Disorders: A Significant Target for Efficient Treatment Approach
All biological tissues and bodily fluids include the autacoid adenosine. The P1 class of purinergic receptors includes adenosine receptors. Four...
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Adenosine receptor A1 enhanced mitochondrial biogenesis and exerted neuroprotection after cerebral ischemia through PGC-1α
Ischemic stroke is a common cause of morbidity and mortality worldwide. The current treatment fails to achieve satisfactory results, because...
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Adenosine as a Key Mediator of Neuronal Survival in Cerebral Ischemic Injury
Several experimental studies have linked adenosine’s neuroprotective role in cerebral ischemia. During ischemia, adenosine is formed due to...
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Species dependence of A3 adenosine receptor pharmacology and function
Efforts to fully understand pharmacological differences between G protein-coupled receptor (GPCR) species homologues are generally not pursued in...
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Evaluation of chemical constituents of Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia) as adenosine A1/A2A receptor ligands
Rooibos ( Aspalathus linearis ) and Honeybush ( Cyclopia intermedia ) are popular tisanes in South Africa and are of growing interest due to the wide...
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Adenosine receptor signalling in Alzheimer’s disease
Alzheimer’s disease (AD) is the most common dementia in the elderly and its increasing prevalence presents treatment challenges. Despite a better...
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Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells
The A 3 adenosine receptor (AR) is an important inflammatory and immunological target. However, the underlying mechanisms are not fully understood....
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Gene regulation in activated microglia by adenosine A3 receptor agonists: a transcriptomics study
Most neurodegenerative disorders, including the two most common, Alzheimer’s disease (AD) and Parkinson’s disease (AD), course with activation of...
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Development of Purinergic Receptor Agonists and Antagonists
Adenosine, P2Y, and P2X receptors have been the focus of purinergic ligand development in the pharmaceutical sector and academic medicinal chemistry...
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Aberrant adenosine signaling in patients with focal cortical dysplasia
Focal cortical dysplasia (FCD), a common malformation of cortical development, is frequently associated with pharmacoresistant epilepsy in both...
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Adenosine restrains ILC2-driven allergic airway inflammation via A2A receptor
Although group 2 Innate Lymphoid Cells (ILC2s) play important roles in driving the pathogenesis of allergic airway inflammation, the molecular...
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The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors
Inosine has robust neuroprotective effects, but it is unclear if inosine acts as direct ligand of adenosine receptors or if it triggers metabolic...
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Covalently Binding Adenosine A3 Receptor Agonist ICBM Irreversibly Reduces Voltage-Gated Ca2+ Currents in Dorsal Root Ganglion Neurons
Interest has been focused in recent years on the analgesic effects exerted by adenosine and its receptors, A 1 , A 2A , A 2B , and A 3 adenosine receptor...
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Effect of chronic maternal L-Glu intake during gestation and/or lactation on oxidative stress markers, AMPA Glu1 receptor and adenosine A1 signalling pathway from foetal and neonatal cerebellum
L-Glutamate (L-Glu) is an amino acid present in the diet that plays a fundamental role in the central nervous system, as the main excitatory...
