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Genetic variation at innate and adaptive immune genes – contrasting patterns of differentiation and local adaptation in a wild gull
Immunogenetic variation in natural vertebrate populations is expected to respond to spatial and temporal fluctuations in pathogen assemblages. While...
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Rolling down that mountain: microgeographical adaptive divergence during a fast population expansion along a steep environmental gradient in European beech
Forest tree populations harbour high genetic diversity thanks to large effective population sizes and strong gene flow, allowing them to diversify...
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Representing stimulus motion with waves in adaptive neural fields
Traveling waves of neural activity emerge in cortical networks both spontaneously and in response to stimuli. The spatiotemporal structure of waves...
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Putative Local Adaptive SNPs in the Genus Avicennia
The genus Avicennia with eight species grow in intertidal zones of tropical and temperate regions, ranging in distribution from West Asia, to...
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Adaptive selection at G6PD and disparities in diabetes complications
Diabetes complications occur at higher rates in individuals of African ancestry. Glucose-6-phosphate dehydrogenase deficiency (G6PDdef), common in...
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On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity
For over half a century, deciphering the origins of the genomic loci that form the jawed vertebrate adaptive immune response has been a major topic...
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Adaptive circuit dynamics across human cortex during evidence accumulation in changing environments
Many decisions under uncertainty entail the temporal accumulation of evidence that informs about the state of the environment. When environments are...
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Using a haptic dynamic clamp to reduce arousal: preference, arousal, and coordination stability are related
We have developed a haptic dynamic clamp dedicated to the regulation of arousal. It takes the form of a vibrating stress ball to be squeezed, called...
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Population genetic differentiation and genomic signatures of adaptation to climate in an abundant lizard
Species distributed across climatic gradients will typically experience spatial variation in selection, but gene flow can prevent such selection from...
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Changes in the DNA Methylation Pattern on Formation of Adaptive and Pathological Responses of Telencephalon Neurons to Hypobaric Hypoxia
Objective. To study changes in the level of DNA methylation in rat neocortex and hippocampus cells on exposure to different hypobaric hypoxia...
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Cross-Adaptation: from F. Z. Meerson to the Present. Part 2. Mechanisms of Cross-Adaptation
This review discusses the physiological mechanisms underlying the phenomenon of cross-adaptation of humans and animals to harmful and stress factors...
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Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice
Despite intense efforts to develop efficient therapeutic regimes for asthma, there is a large demand for novel treatment strategies in this disease....
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Long-Term and Seasonal Dynamics of Inversion Polymorphism in the Malaria Mosquito Anopheles messeae Fall. (Diptera: Culicidae) from the Population of the Central Part of the Species Range (Western Siberia, Tomsk Oblast)
AbstractThe level of genetic variability in the population of malaria mosquito Anopheles messeae Fall. from the settlement of Kolarovo (Tomsk...
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Features of α2-Adrenergic Regulation of Isolated Rat Heart after Hypokinesia
We studied the effect of the α 2 -adrenergic receptor agonist clonidine hydrochloride (10 —9 -10 —6 M) on the isolated heart of adult rats after 30-day...
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Neural Sequences and the Encoding of Time
Converging experimental and computational evidence indicate that on the scale of seconds the brain encodes time through changing patterns of neural...
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Temperature, season, and latitude influence development-related phenotypes of Philippine Aedes aegypti (Linnaeus): Implications for dengue control amidst global warming
BackgroundDengue is endemic in the Philippines. Aedes aegypti is the primary vector. This study aimed to determine the hatching behavior and...
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Laboratory and microcosm experiments reveal contrasted adaptive responses to ammonia and water mineralisation in aquatic stages of the sibling species Anopheles gambiae (sensu stricto) and Anopheles coluzzii
BackgroundThe sibling species of the malaria mosquito, Anopheles gambiae (sensu stricto) and Anopheles coluzzii co-exist in many parts of West...
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Population replacement gene drive characteristics for malaria elimination in a range of seasonal transmission settings: a modelling study
BackgroundGene drives are a genetic engineering method where a suite of genes is inherited at higher than Mendelian rates and has been proposed as a...
