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Circulating long non-coding RNAs detection after heart transplantation and its accuracy in the diagnosis of acute cardiac rejection
Long non-coding RNAs (lncRNAs) are closely implicated in biological processes and diseases with high inflammatory components. These molecules exhibit...
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Acute kidney rejection after anti-SARS-CoV-2 virus-vectored vaccine—case report
COVID-19 infection remains a threat to the health systems of many countries. Potential success in the fight against the COVID-19 pandemic is the...
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Cell-free DNA for the detection of kidney allograft rejection
Donor-derived cell-free DNA (dd-cfDNA) is an emerging noninvasive biomarker that has the potential to detect allograft injury. The capacity of...
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Association between time in therapeutic range of tacrolimus blood concentration and acute rejection within the first three months after lung transplantation
BackgroundTacrolimus is a key drug in immunosuppressive therapy following lung transplantation. The blood tacrolimus levels are likely to fluctuate...
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Granzyme B–Producing B Cells Function as a Feedback Loop for T Helper Cells in Liver Transplant Recipients with Acute Rejection
Granzyme B–producing B cells have been reportedly reported to be an important regulatory B cell subset in the pathogenesis of many diseases. However,...
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Interferon-γ and its response are determinants of antibody-mediated rejection and clinical outcomes in patients after renal transplantation
Interferon-γ (IFN-γ) is an important cytokine in tissue homeostasis and immune response, while studies about it in antibody-mediated rejection (ABMR)...
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Meta-analysis of the associations of IMPDH and UGT1A9 polymorphisms with rejection in kidney transplant recipients taking mycophenolic acid
PurposeTo investigate the associations of IMPDH and UGT1A9 polymorphisms with rejection in kidney transplant recipients taking mycophenolic acid...
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Preventative effect of TSPO ligands on mixed antibody-mediated rejection through a Mitochondria-mediated metabolic disorder
BackgroundImmune-mediated rejection was the major cause of graft dysfunction. Although the advances in immunosuppressive agents have markedly reduced...
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Mouse Models of Renal Allograft Transplant Rejection: Methods to Investigate Chemokine–GAG Interaction and Therapeutic Blockade
Chemokine–glycosaminoglycan (GAG) interactions direct immune cell activation and invasion, e.g., directing immune cells to sites of infection or...
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Liquid Biopsy, a Potential New Detection Method in Heart Allograft Rejection
Allografts rejection remains the most important reason causing allograft dysfunction in heart transplantation recipients. Currently, the golden...
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Deep learning-enabled assessment of cardiac allograft rejection from endomyocardial biopsies
Endomyocardial biopsy (EMB) screening represents the standard of care for detecting allograft rejections after heart transplant. Manual...
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Ferroptosis related gene signature in T cell-mediated rejection after kidney transplantation
BackgroundT cell-mediated rejection is an important factor affecting early transplant kidney survival. Ferroptosis has been shown to play a...
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A combination of the percentages of IFN-γ+CD4+T cells and granzyme B+CD19+B cells is associated with acute hepatic rejection: a case control study
BackgroundT cells and B cells play a key role in alloimmune responses. We aimed to characterize the shift of T cell subsets and B cell subsets during...
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Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers
Systemic immunosuppression for the mitigation of immune rejection after organ transplantation causes adverse side effects and constrains the...
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Integrative metagenomic and metabolomic analyses reveal the role of gut microbiota in antibody-mediated renal allograft rejection
BackgroundAntibody-mediated rejection (AMR) remains one of the major barriers for graft survival after kidney transplantation. Our previous study...
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Heat shock protein 90 is a new potential target of anti-rejection therapy in allotransplantation
The critical roles of heat shock protein 90 (HSP90) in immune reactions associated with viral infection and autoimmune disease are well known. To...
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Circulating cell-free nucleosomes as biomarker for kidney transplant rejection: a pilot study
BackgroundThere is an unmet need for noninvasive markers specific for kidney transplant rejection. Such a marker may eventually overcome the need for...
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Multiplex Immunofluorescence for Detection of Spatial Distributions of Infiltrating T Cells Within Different Regions of Hepatic Lobules During Liver Transplantation Rejection
It remains unclear as to whether there are differences that exist in the types and functional status of immune cells within different areas of the...
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Tacrolimus monitoring parameters are not associated with acute cellular rejection following lung transplantation
PurposeThe purpose of this study was to evaluate the impact of tacrolimus drug monitoring parameters on the incidence of acute cellular rejection...