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Erythrocyte Acetylcholinesterase as a Biomarker of Environmental Lead Exposure
Lead is a prime, ubiquitous, environmental toxicant and multi-organ poison. One of the most recognized deleterious effects of lead exposure is...
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The Time Profile of the Effects of Moderate Hypothermia on Synaptic Acetylcholinesterase in Rat Brain
Hypothermia in homeotherms significantly affects the neurotransmitter systems of the brain, including the cholinergic system. The function of the...
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Determination of Acetylcholinesterase Activity Based on Ratiometric Fluorescence Signal Sensing
Acetylcholinesterase (AChE) plays an important role in the treatment of human diseases, environmental security and global food supply. In this study,...
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Erythrocyte Acetylcholinesterase as a Biomarker of Environmental Lead Exposure
Lead is a prime, ubiquitous, environmental toxicant and multi-organ poison. One of the most recognized deleterious effects of lead exposure is...
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Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors
In this study, a total of 13 compounds (5 – 17) were synthesized starting from oleanolic acid (OA), a natural triterpenoid. Five new compounds (10, 11,...
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Virtual screening of acetylcholinesterase inhibitors through pharmacophore-based 3D-QSAR modeling, ADMET, molecular docking, and MD simulation studies
Alzheimer’s disease (AD) is a leading cause of dementia in elderly patients. The pathophysiology of AD includes various pathways, such as the...
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Design, synthesis and assay of 2-(4-phenylpiperazin-1-yl)pyrimidine-5- carboxamide derivatives as acetylcholinesterase inhibitors
A series of 2-(4-phenylpiperazin-1-yl)pyrimidine-5-carboxamide derivatives as acetylcholinesterase inhibitors (AChEIs) were designed and synthesized...
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The therapeutic effect of BODIPY-based photosensitizers against acetylcholinesterase for the treatment of Alzheimer’s disease
The alzheimer disease (AD) origination and promulgation are closely associated with the acetylcholinesterase (AChE) enzyme. The management of AD...
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Acetylcholinesterase Inhibition Assays for High-Throughput Screening
Acetylcholinesterase (AChE) hydrolyzes acetylcholine (ACh), a vital neurotransmitter that regulates muscle movement and brain function, including...
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Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways
BackgroundTrastuzumab (Trz)-induced cardiotoxicity (TIC) is one of the most common adverse effects of targeted anticancer agents. Although oxidative...
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Bioactivity-guided isolation of anti-acetylcholinesterase compounds from Odontites vulgaris Moench
This study aimed to separate the anti-acetylcholinesterase (anti-AChE) compounds from Odontites vulgaris Moench, a member of the Orobanchaceae famly,...
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Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase
Hypothyroidism causes learning and memory impairment. Considering the neuroprotective properties of thiamine (Vitamin B1), this study was conducted...
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Evaluation of antibacterial, antioxidant, cytotoxic, and acetylcholinesterase inhibition activities of novel [1,4] benzoxazepines fused to heterocyclic systems with a molecular modeling study
Microbial pathogenesis, cancer progression, and neurological diseases are associated with oxidative stress due to the increased production of...
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Alzheimer’s disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder with progressive loss of memory and other cognitive functions. The...
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Immunohistochemistry for acetylcholinesterase and butyrylcholinesterase in the dorsal motor nucleus of the vagus (DMNV) of formalin-fixed, paraffin-embedded tissue: comparison with reported literature
The majority of research regarding the expression of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the brain has been conducted...
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Memantine and Its Combination with Acetylcholinesterase Inhibitors in Pharmacological Pretreatment of Soman Poisoning in Mice
Nerve agents pose a real threat to both the military and civil populations, but the current treatment of the poisoning is unsatisfactory. Thus, we...
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Computational identification of potential acetylcholinesterase (AChE) and monoamine oxidase-B inhibitors from Vitis vinifera: a case study of Alzheimer’s disease (AD)
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease that affects people aged 60 years and above. Yet, the discovery of potent...
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Cliniatines A–C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase
Cliniatines A–C ( 1 – 3 ), three new Amaryllidaceae alkaloids, consisting of 2,6-dimetylpyridine and lycorine-type and/or galanthamine-type were isolated...
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Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series?
The misuse of novichok agents in assassination attempts has been reported in the international media since 2018. These relatively new class of...
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Acetylcholinesterase (AChE) Activity in Embryos of Zebrafish
Acetylcholinesterase (AChE) is a useful biomarker for organophosphate and carbamate pesticides exposure. The inhibition of this enzyme has been...