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Genome-wide ATAC-see screening identifies TFDP1 as a modulator of global chromatin accessibility
Chromatin accessibility is a hallmark of active regulatory regions and is functionally linked to transcriptional networks and cell identity. However,...
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Inferring chromatin accessibility during murine hematopoiesis through phylogenetic analysis
ObjectiveDiversification of cell types and changes in epigenetic states during cell differentiation processes are important for understanding...
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Systematic assessment of ISWI subunits shows that NURF creates local accessibility for CTCF
Catalytic activity of the imitation switch (ISWI) family of remodelers is critical for nucleosomal organization and DNA binding of certain...
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Identification of lineage-specific epigenetic regulators FOXA1 and GRHL2 through chromatin accessibility profiling in breast cancer cell lines
Breast cancer is a heterogeneous disease, and breast cancer cell lines are invaluable for studying this heterogeneity. However, the epigenetic...
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Increasing Diversity, Equity, Inclusion, and Accessibility in Rare Disease Clinical Trials
Diversity, equity, inclusion, and accessibility (DEIA) are foundational principles for clinical trials and medical research. In rare diseases...
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The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease
To characterize the dysregulation of chromatin accessibility in Alzheimer’s disease (AD), we generated 636 ATAC-seq libraries from neuronal and...
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Super-enhancer RNA m6A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma
The biological functions of noncoding RNA N 6 -methyladenosine (m 6 A) modification remain poorly understood. In the present study, we depict the...
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PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility
BackgroundNeuroendocrine prostate cancer (NEPC) is a lethal subset of prostate cancer which is characterized by neuroendocrine differentiation and...
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Chromatin profile-based identification of a novel ER-positive breast cancer subgroup with reduced ER-responsive element accessibility
BackgroundOestrogen receptor (ER) signalling-dependent cancer cell growth is one of the major features of ER-positive breast cancer (BC). Inhibition...
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Integrative analysis of chromatin accessibility and transcriptome landscapes in the induction of peritoneal fibrosis by high glucose
BackgroundPeritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis.
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Closing the accessibility gap to mental health treatment with a personalized self-referral chatbot
Inequality in treatment access is a pressing issue in most healthcare systems across many medical disciplines. In mental healthcare, reduced...
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RNA m6A regulates transcription via DNA demethylation and chromatin accessibility
Transcriptional regulation, which integrates chromatin accessibility, transcription factors and epigenetic modifications, is crucial for establishing...
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The chromatin accessibility and transcriptomic landscape of the aging mice cochlea and the identification of potential functional super-enhancers in age-related hearing loss
BackgroundPresbycusis, also referred to as age-related hearing loss (ARHL), is a condition that results from the cumulative effects of aging on an...
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Chromatin accessibility analysis suggested vascular induction of the biliary epithelium via the Notch signaling pathway in the human liver
The biliary epithelial cells (cholangiocytes) in the liver originate from undifferentiated liver parenchymal cells (hepatoblasts) that are located...
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Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas
BackgroundInvasive lobular breast carcinoma (ILC), the second most prevalent histological subtype of breast cancer, exhibits unique molecular...
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Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms
While many germline cancer risk variants have been identified through genome-wide association studies (GWAS), the mechanisms by which these variants...
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