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1. A retrospective study of the efficacy of JAK inhibitors or abatacept on rheumatoid arthritis-interstitial lung disease

   Objectives

   To examine the effectiveness of Janus-kinase inhibitors (JAKis) or abatacept (ABA) in patients with rheumatoid arthritis-interstitial lung...

   Marika Tardella, Marco Di Carlo, ... Fausto Salaffi in Inflammopharmacology

   Article Open access 24 April 2022
   

2. Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis

   Primary Sclerosing Cholangitis (PSC) is a progressive cholestatic liver disease with no licensed therapies. Previous Genome Wide Association Studies...

   Jessica Leighton, David E. J. Jones, ... Heather J. Cordell in BMC Medical Genomics

   Article Open access 11 June 2024
   

3. Fetal and Neonatal Adverse Drug Reactions Associated with Biologics Taken During Pregnancy by Women with Autoimmune Diseases: Insights from an Analysis of the World Health Organization Pharmacovigilance Database (VigiBase^®)

   Introduction

   Published data on the safety of biologics other than tumor necrosis factor (TNF) inhibitors during pregnancy are limited.

   ...

   Amandine Dernoncourt, Sophie Liabeuf, ... Benjamin Batteux in BioDrugs

   Article Open access 19 November 2022
   

4. Abatacept induced granulomatous hepatitis with a sarcoidosis- like reaction: a blinded trial in mice

   Background

   Abatacept is increasingly used for rheumatoid arthritis (RA) and juvenile idiophathic arthritis (JIA) treatment. However little is known...

   Sultan M. Almogairen in BMC Pharmacology and Toxicology

   Article Open access 07 May 2019
   

5. Monogenic inborn errors of immunity in autoimmune disorders

   To estimate the prevalence of monogenic inborn errors of immunity in patients with autoimmune diseases (AID), the study included 56 subjects...

   Iyengar Vaishnavi Venkatachari, Akshaya Chougule, ... Mukesh Desai in Immunologic Research

   Article 18 May 2023
   

6. A compendium of mitochondrial molecular characteristics provides novel perspectives on the treatment of rheumatoid arthritis patients

   Rheumatoid arthritis (RA) is an autoimmune disease that exhibits a high degree of heterogeneity, marked by unpredictable disease flares and...

   Qi Wang, Qi-Chao Gao, ... Pei-Feng He in Journal of Translational Medicine

   Article Open access 22 August 2023
   

7. Role of booster with BNT162b2 mRNA in SARS-CoV-2 vaccination in patients with rheumatoid arthritis

   Only case reports and small clinical series report the effects of booster vaccination with BNT162b2 in patients with rheumatoid arthritis (RA). We...

   Maurizio Benucci, Arianna Damiani, ... Mariangela Manfredi in Immunologic Research

   Article 11 May 2022
   

8. Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes

   Follicular helper T (T _FH ) cells are implicated in type 1 diabetes (T1D), and their development has been linked to CD28 costimulation. We tested...

   Natalie M. Edner, Frank Heuts, ... Lucy S. K. Walker in Nature Immunology

   Article 03 August 2020
   

9. Clinical Characteristics of Pediatric Patients with LRBA Deficiency in Mexico

   Eduardo Liquidano-Perez, Selma Scheffler-Mendoza, ... Gabriela Lopez-Herrera in Journal of Clinical Immunology

   Article 06 March 2024

10. Immune-checkpoint inhibitor-mediated myocarditis: CTLA4, PD1 and LAG3 in the heart

    Immune-checkpoint inhibitors (ICIs) have revolutionized oncology, with nearly 50% of all patients with cancer eligible for treatment with ICIs....

    Amir Z. Munir, Alan Gutierrez, ... Javid J. Moslehi in Nature Reviews Cancer

    Article 09 July 2024
    

11. Antibody-Based Biotherapeutics in Inflammatory Diseases

    Inflammatory diseases encompass a broad and diverse spectrum of serious chronic disorders, many of which have significant need for safe and effective...

    Yan Xu, Jia Chen, Honghui Zhou in Pharmaceutical Biotechnology

    Chapter 2024
    

12. Artificial intelligence-powered discovery of small molecules inhibiting CTLA-4 in cancer

    Background/Objectives

    Checkpoint inhibitors, which generate durable responses in many cancer patients, have revolutionized cancer immunotherapy....

    Navid Sobhani, Dana Rae Tardiel-Cyril, ... Yong Li in BJC Reports

    Article Open access 23 January 2024
    

13. Bispecific T cell engager therapy for refractory rheumatoid arthritis

    Bispecific T cell engagers (BiTEs) kill B cells by engaging T cells. BiTEs are highly effective in acute lymphoblastic leukemia. Here we treated six...

    Laura Bucci, Melanie Hagen, ... Ricardo Grieshaber-Bouyer in Nature Medicine

    Article 26 April 2024
    

14. Beispiele für entzündliche Immunpathologien

    Als Beispiele für entzündliche Immunopathien werden folgende besprochen: Sepsis, Asthma, Diabetes Typ 1, Multiple Sklerose, Rheumatoide Arthritis,...

    Barbara M. Bröker, Bernhard Fleischer in Grundwissen Immunologie

    Chapter 2023
    

15. Absorption, Distribution, Metabolism and Excretion of Biopharmaceutical Drug Products

    Biopharmaceuticals are playing an increasing role in therapy; as a subset of therapeutics, their proportional use relative to traditional small drugs...

    Molly Graveno, Robert E. Stratford in ADME Processes in Pharmaceutical Sciences

    Chapter 2024
    

16. Retention Rate and Safety of Biologic and Targeted Synthetic DMARDs in Patients with RA-Associated Interstitial Lung Disease: A KOBIO Registry Study

    Objectives

    This study aimed to evaluate the long-term retention and safety of biologic disease-modifying antirheumatic drugs (bDMARDs) and targeted...

    Sun-Kyung Lee, Kichul Shin, ... Hyoun-Ah Kim in BioDrugs

    Article 09 February 2023
    

17. Rheumatoid arthritis-associated complications during pregnancy and its effect on offspring: comprehensive review

    This study comprehensively explores the complexities of rheumatoid arthritis during pregnancy and its impact on offspring. Through an extensive...

    S. Rohini, Uday Raj Sharma, ... Manjunatha P. Mudagal in Inflammopharmacology

    Article 30 April 2024
    

18. Biologics and Targeted Synthetic Drugs Can Induce Immune-Mediated Glomerular Disorders in Patients with Rheumatic Diseases: An Updated Systematic Literature Review

    Objective

    Our objective was to update the understanding of the development of paradoxical immune-mediated glomerular disorders (IGDs) in patients with...

    Elisabetta Chessa, Matteo Piga, ... Alberto Cauli in BioDrugs

    Article Open access 17 February 2021
    

19. A Quantitative Prediction Method for the Human Pharmacokinetics of Fc-Fusion Proteins

    Background and Objective

    Fc fusion is an effective strategy for extending the half-lives of therapeutic proteins. This study aimed to evaluate the...

    Miki Yokoyama, Eiko Suzuki, ... Nobuaki Watanabe in European Journal of Drug Metabolism and Pharmacokinetics

    Article 02 August 2023
    

20. BCG-Related Inflammatory Syndromes in Severe Combined Immunodeficiency After TCRαβ+/CD19+ Depleted HSCT

    Introduction

    The live-attenuated BCG vaccine is known to cause disseminated Mycobacterium bovis infection in patients with severe combined...

    Alexandra Laberko, Daria Yukhacheva, ... Anna Shcherbina in Journal of Clinical Immunology

    Article 06 May 2020