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Plasma-derived extracellular vesicles transfer microRNA-130a-3p to alleviate myocardial ischemia/reperfusion injury by targeting ATG16L1
Extracellular vesicles (EVs) are implicated in myocardial ischemia/reperfusion (I/R) injury as modulators by shuttling diverse cargoes, including...
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Autophagic reprogramming of bone marrow–derived macrophages
Macro-autophagy is a highly conserved catabolic process among eukaryotes affecting macrophages. This work studies the genetic regulatory network...
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PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy
Lysosomes function as critical signaling hubs that govern essential enzyme complexes. LGALS proteins (LGALS3, LGALS8, and LGALS9) are integral to the...
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M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma
BackgroundEmerging evidence suggest the critical role of circular RNAs (circRNAs) in disease development especially in various cancers. However, the...
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Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis
The human immunity-related GTPase M (IRGM) is a GTP-binding protein that regulates selective autophagy including xenophagy and mitophagy. IRGM...
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Entamoeba histolytica exploits the autophagy pathway in macrophages to trigger inflammation in disease pathogenesis
The mechanism whereby Entamoeba histolytica ( Eh ) binding with macrophages at the intercellular junction triggers aggressive pro-inflammatory...
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Acetaldehyde Induces Cytotoxicity via Triggering Mitochondrial Dysfunction and Overactive Mitophagy
Overconsumption of alcohol damages brain tissue and causes cognitive dysfunction. It has been suggested that the neurotoxicity caused by excessive...
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Polymorphisms in autophagy genes are genetic susceptibility factors in glioblastoma development
BackgroundGlioblastoma is the most aggressive and common malignant primary brain tumor in adults. Many genetic, epigenetic and genomic mutations have...
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EPB41L4A-AS1 is required to maintain basal autophagy to modulates Aβ clearance
Alzheimer’s disease (AD) is the most common neurodegenerative disorder characterized by the deposition of β-amyloid (Aβ) plaques. Aβ is generated...
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Autophagy in the Intestinal Stem Cells
Intestinal epithelial cells that are exposed to damage caused by the contents of the lumen die, and therefore a continuous and rapid turnover takes...
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Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non‐transformed skeletal muscle cells
PurposeRecent work has highlighted the therapeutic potential of targeting autophagy to modulate cell survival in a variety of diseases including...
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Autophagy in Embryonic Stem Cells and Neural Stem Cells
AutophagyAutophagy is a conserved cytoprotective catabolic pathway that plays a crucial role in cellular turnover and homeostasis in eukaryotic...
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Axonal autophagic vesicle transport in the rat optic nerve in vivo under normal conditions and during acute axonal degeneration
Neurons pose a particular challenge to degradative processes like autophagy due to their long and thin processes. Autophagic vesicles (AVs) are...
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Periodontopathogen-Related Cell Autophagy—A Double-Edged Sword
The periodontium is a highly organized ecosystem, and the imbalance between oral microorganisms and host defense leads to periodontal diseases. The...
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Role and molecular mechanism of NOD2 in chronic non-communicable diseases
Nucleotide-binding oligomerization domain containing 2 (NOD2), located in the cell cytoplasm, is a pattern recognition receptor belonging to the...
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Autophagy genes in biology and disease
Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes that degrade cytoplasmic material in lysosomes. Both pathways...
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Oxidative Stress-Induced Autophagy
The term “autophagy” was first coined by Christian de Duve in 1965, on observation of increased number of lysosomes in rat liver cells after the...
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Oxidative Stress-Induced Autophagy
The term “autophagy” was first coined by Christian de Duve in 1965, on observation of increased number of lysosomes in rat liver cells after the...
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Exploring and exploiting the host cell autophagy during Mycobacterium tuberculosis infection
Tuberculosis, caused by Mycobacterium tuberculosis , is a fatal infectious disease that prevails to be the second leading cause of death from a single...
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Predictive biomarkers for anti-TNF alpha therapy in IBD patients
Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition characterized by severe gut inflammation, commonly presenting as Crohn’s...
