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Involvement of ANO1 currents in pacemaking of PDGFRα-positive specialised smooth muscle cells in rat caudal epididymis
The epididymal duct exhibits spontaneous phasic contractions (SPCs) to store and transport sperm. Here, we explored molecular identification of...
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Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract
Inflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized by high levels of pulmonary cytokines. Two well-established...
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Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A)
Various human tissues express the calcium-activated chloride channel Anoctamin 1 (ANO1), also known as TMEM16A. ANO1 allows the passive chloride flux...
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Ca2+ Signaling Is the Basis for Pacemaker Activity and Neurotransduction in Interstitial Cells of the GI Tract
Years ago gastrointestinal motility was thought to be due to interactions between enteric nerves and smooth muscle cells (SMCs) in the tunica...
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Anoctamin 1 antagonism potentiates conventional tocolytic-mediated relaxation of pregnant human uterine smooth muscle
BackgroundCurrently available tocolytic agents are not effective treatment for preterm labor beyond 48 h. A major reason is the development of...
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Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles
A transmembrane (TMEM) protein with an unknown function is a type of membrane-spanning protein expressed in the plasma membrane or the membranes of...
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Transcriptome analysis reveals the prognostic and immune infiltration characteristics of glycolysis and hypoxia in head and neck squamous cell carcinoma
BackgroundThis study aims to construct a new prognostic gene signature in survival prediction and risk stratification for patients with Head and neck...
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Molecular logic of salt taste reception in special reference to transmembrane channel-like 4 (TMC4)
The taste is biologically of intrinsic importance. It almost momentarily perceives environmental stimuli for better survival. In the early 2000s,...
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Sperm epigenetics and male infertility: unraveling the molecular puzzle
BackgroundThe prevalence of infertility among couples is estimated to range from 8 to 12%. A paradigm shift has occurred in understanding of...
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MYEOV with High Frequencies of Mutations in Head and Neck Cancers Facilitates Cancer Cell Malignant Behaviors
Cancer driver genes (CDGs) and the driver mutations disrupt the homeostasis of numerous critical cell activities, thereby playing a critical role in...
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Pathophysiological role of ion channels and transporters in HER2-positive breast cancer
The incidence of breast cancer (BC) has been increasing each year, and BC is now the most common malignant tumor in women. Among the numerous BC...
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Anoctamin 1/TMEM16A controls intestinal Cl− secretion induced by carbachol and cholera toxin
Calcium-activated chloride channels (CaCCs) mediate numerous physiological functions and are best known for the transport of electrolytes and water...
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The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration
BackgroundMyelin sheath is a crucial accessory to the functional nerve-fiber unit, its disruption or loss can lead to axonal degeneration and...
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Involvement of TRPV1-ANO1 Interactions in Pain-Enhancing Mechanisms
Primary sensory neurons detect potentially dangerous environmental situations via many “sensor” proteins located on the plasma membrane. Although...
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ANO10 Function in Health and Disease
Anoctamin 10 (ANO10), also known as TMEM16K, is a transmembrane protein and member of the anoctamin family characterized by functional duality....
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Increased copy number of imprinted genes in the chromosomal region 20q11-q13.32 is associated with resistance to antitumor agents in cancer cell lines
BackgroundParent of origin-specific allelic expression of imprinted genes is epigenetically controlled. In cancer, imprinted genes undergo both...
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Piezo1, the new actor in cell volume regulation
All animal cells control their volume through a complex set of mechanisms, both to counteract osmotic perturbations of the environment and to enable...
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A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise
Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region...
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The Role οf Ion Channels in the Development and Progression of Prostate Cancer
Ion channels have major regulatory functions in living cells. Apart from their role in ion transport, they are responsible for cellular...
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The Mutual Regulatory Role of Ferroptosis and Immunotherapy in Anti-tumor Therapy
Ferroptosis is a form of cell death that is triggered by the presence of ferrous ions and is characterized by lipid peroxidation induced by these...
