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Biomedicine

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Showing 1-20 of 52 results

  1. Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression

    Background

    Gliomas account for the majority of primary human brain tumors and remain a challenging neoplasm for cure due to limited therapeutic...

    Qiong Jiang, Qing **e, ... Weijiang Zhao in BMC Cancer
    Article Open access 12 September 2019

  2. Spider venom components decrease glioblastoma cell migration and invasion through RhoA-ROCK and Na+/K+-ATPase β2: potential molecular entities to treat invasive brain cancer

    Background

    Glioblastoma (GB) cells have the ability to migrate and infiltrate the normal parenchyma, leading to the formation of recurrent tumors...

    Natália Barreto, Marcus Caballero, ... Catarina Rapôso in Cancer Cell International
    Article Open access 17 December 2020

  3. A Functional Interaction Between Na,K-ATPase β2-Subunit/AMOG and NF2/Merlin Regulates Growth Factor Signaling in Cerebellar Granule Cells

    The Na,K-ATPase, consisting of a catalytic α-subunit and a regulatory β-subunit, is a ubiquitously expressed ion pump that carries out the transport...

    Alisa Litan, Zhiqin Li, ... Sigrid A. Langhans in Molecular Neurobiology
    Article 06 May 2019

  4. Cuprotosis clusters predict prognosis and immunotherapy response in low-grade glioma

    Cuprotosis, an emerging mode of cell death, has recently caught the attention of researchers worldwide. However, its impact on low-grade glioma (LGG)...

    Wenjun Zhu, Ziqi Chen, ... Guangyuan Hu in Apoptosis
    Article Open access 15 September 2023

  5. Na,K-ATPase α1 and β-subunits show distinct localizations in the nervous tissue of the large milkweed bug

    The Na,K-ATPase (NKA) is an essential ion transporter and signaling molecule in all animal tissues and believed to consist at least one α and one...

    Marlena Herbertz, Sönke Harder, ... Susanne Dobler in Cell and Tissue Research
    Article Open access 25 March 2022

  6. IDH Inhibitors and Beyond: The Cornerstone of Targeted Glioma Treatment

    Diffuse low-grade gliomas account for approximately 20% of all primary brain tumors, they arise from glial cells and show infiltrative growth without...

    Lidia Gatto, Enrico Franceschi, ... Alba Ariela Brandes in Molecular Diagnosis & Therapy
    Article 07 June 2021

  7. The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility

    Malignant gliomas are the most common tumors in the central nervous system (CNS) and, unfortunately, are also the most deadly. The lethal nature of...
    Kristin A. Giamanco, Russell T. Matthews in Tumor Microenvironment
    Chapter 2020

  8. Trends in pancreatic adenocarcinoma incidence and mortality in the United States in the last four decades; a SEER-based study

    Background

    Pancreatic cancer is the fourth-leading cause of cancer deaths in the United States. The silent nature of the disease and its poor...

    Anas M. Saad, Tarek Turk, ... Omar Abdel-Rahman in BMC Cancer
    Article Open access 25 June 2018

  9. Membrane Transporters and Channels in Melanoma

    Recent research has revealed that ion channels and transporters can be important players in tumor development, progression, and therapy resistance in...
    Ines Böhme, Roland Schönherr, ... Anja Katrin Bosserhoff in Transportome Malfunction in the Cancer Spectrum
    Chapter 2020

  10. Glyco-Functionalysed Biomaterials in Neuroregeneration

    The key signalling roles played by glycans (simple or complex) in the development of smart biomaterials for neuroregeneration is reported. The...
    Laura Russo, Antonella Sgambato, ... Francesco Nicotra in Drug and Gene Delivery to the Central Nervous System for Neuroprotection
    Chapter 2017

  11. Plant Latex Proteases: Natural Wound Healers

    Proteases are ubiquitously present in several organisms including plants. In plants, one of the rich sources of protease is latex. Over 110 latices...
    Amog P. Urs, V. N. Manjuprasanna, ... B. S. Vishwanath in Proteases in Physiology and Pathology
    Chapter 2017

  12. Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity

    Background

    The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh...

    Seung Joon Lee, Alisa Litan, ... Sigrid A. Langhans in Molecular Cancer
    Article Open access 19 August 2015

  13. Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2

    Background

    The majority of neurons within the central nervous system receive their excitatory inputs via small, actin-rich protrusions called...

    Tasnuva Sarowar, Stefanie Grabrucker, ... Andreas M. Grabrucker in Molecular Brain
    Article Open access 11 March 2016

  16. Systematic Review of Protein Biomarkers of Invasive Behavior in Glioblastoma

    Glioblastoma (GBM) is an aggressive and incurable brain tumor with a grave prognosis. Recurrence is inevitable even with maximal surgical resection,...

    Eli T. Sayegh, Gurvinder Kaur, ... Andrew T. Parsa in Molecular Neurobiology
    Article 24 November 2013

  17. Gangliogliomas: Molecular Pathogenesis and Epileptogenesis

    Gangliogliomas (GG) constitute the most frequent tumor entity in young patients undergoing surgery for intractable epilepsy. Surgery provides the...
    Eleonora Aronica, Pitt Niehusmann in Tumors of the Central Nervous System, Volume 5
    Chapter 2012

  18. Differential Effect of Postnatal Lead Exposure on Gene Expression in the Hippocampus and Frontal Cortex

    Although developmental lead exposure is known to have detrimental effects on a variety of cognitive functions that depend on the integrity of the...

    J. S. Schneider, W. Mettil, D. W. Anderson in Journal of Molecular Neuroscience
    Article 10 December 2011

  19. Genome-Wide Expression Profiles of Amygdala and Hippocampus in Mice After Fear Conditioning

    The amygdala and hippocampus are known to be involved in the formation of fear conditioning memories, and both contextual and cued fear memory...
    Zheng Zhao, Yinghe Hu in Genomics, Proteomics, and the Nervous System
    Chapter 2011

  20. The effect of sleep deprivation on BOLD activity elicited by a divided attention task

    Sleep loss, widespread in today’s society and associated with a number of clinical conditions, has a detrimental effect on a variety of cognitive...

    Melinda L. Jackson, Matthew E. Hughes, ... Patrick Johnston in Brain Imaging and Behavior
    Article 27 January 2011
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